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Published in: Abdominal Radiology 2/2018

01-02-2018

Radiologic evaluation of patients undergoing the modified Appleby procedure for locally advanced pancreatic neoplasms: a case series

Authors: Merel A. T. Vergauwen, Michele Perillo, Alejandro Garces-Descovich, Courtney E. Barrows, A. James Moser, Koenraad J. Mortelé

Published in: Abdominal Radiology | Issue 2/2018

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Abstract

Purpose

Despite advances in medical and surgical care, pancreatic ductal adenocarcinoma remains one of the most locally aggressive neoplastic processes in the abdomen. Unfortunately, most pancreatic adenocarcinomas present late and are unresectable at time of diagnosis. The modified Appleby procedure is a surgical option in patients with locally advanced pancreatic neoplasms of the body and tail with vascular invasion of the celiac trunk. To our knowledge, no radiologic journal has previously reported on the pre-operative evaluation or postoperative imaging findings of such patients.

Methods

We report herein three patients who underwent the modified Appleby procedure, each with a unique complication, in an attempt to illustrate common pitfalls of interpretation in these advanced cases.

Results

Our case series emphasizes the importance of pre-operative radiologic assessment of variant arterial anatomy, knowledge of pre- and intraoperative procedures and appearances, and familiarity with potential postoperative complications.

Conclusions

Thorough understanding of the important aspects of the pre-surgical anatomy, as well as possible post-surgical complications, is the key to the radiologist being a useful participant in the clinical care of these patients.
Literature
1.
go back to reference Edge S, Byrd DR, Compton CC, et al. (2010) AJCC cancer staging manual, 7th edn. New York: Springer Edge S, Byrd DR, Compton CC, et al. (2010) AJCC cancer staging manual, 7th edn. New York: Springer
2.
go back to reference Wittekind C, Compton C, Quirke P, et al. (2009) A uniform residual tumor (R) classification: integration of the R classification and the circumferential margin status. Cancer 115:3483–3488CrossRefPubMed Wittekind C, Compton C, Quirke P, et al. (2009) A uniform residual tumor (R) classification: integration of the R classification and the circumferential margin status. Cancer 115:3483–3488CrossRefPubMed
3.
go back to reference Appleby LH (1953) The coeliac axis in the expansion of the operation for gastric carcinoma. Cancer 6:704–707CrossRefPubMed Appleby LH (1953) The coeliac axis in the expansion of the operation for gastric carcinoma. Cancer 6:704–707CrossRefPubMed
4.
go back to reference Strasberg SM, Fields R (2012) Left-sided pancreatic cancer. Distal pancreatectomy and its variants: radical antegrade modular pancreatosplenectomy and distal pancreatectomy with celiac axis resection. Cancer J 18:562–570CrossRefPubMed Strasberg SM, Fields R (2012) Left-sided pancreatic cancer. Distal pancreatectomy and its variants: radical antegrade modular pancreatosplenectomy and distal pancreatectomy with celiac axis resection. Cancer J 18:562–570CrossRefPubMed
6.
go back to reference Ham H, Kim SG, Kwon HJ, Ha H, Choi YY (2015) Distal pancreatectomy with celiac axis resection for pancreatic body and tail cancer invading celiac axis. Ann Surg Treat Res 89:167–175CrossRefPubMedPubMedCentral Ham H, Kim SG, Kwon HJ, Ha H, Choi YY (2015) Distal pancreatectomy with celiac axis resection for pancreatic body and tail cancer invading celiac axis. Ann Surg Treat Res 89:167–175CrossRefPubMedPubMedCentral
7.
go back to reference Liu B (2003) Modified Appleby operation in treatment of distal pancreatic cancer. Hepatobiliary Pancreat Dis Int 2:622–625PubMed Liu B (2003) Modified Appleby operation in treatment of distal pancreatic cancer. Hepatobiliary Pancreat Dis Int 2:622–625PubMed
8.
go back to reference Tanaka E, Hirano S, Tsuchikawa T, et al. (2012) Important technical remarks on distal pancreatectomy with en-bloc celiac axis resection for locally advanced pancreatic body cancer (with video). J Hepatobiliary Pancreat Sci 19:141–147CrossRefPubMed Tanaka E, Hirano S, Tsuchikawa T, et al. (2012) Important technical remarks on distal pancreatectomy with en-bloc celiac axis resection for locally advanced pancreatic body cancer (with video). J Hepatobiliary Pancreat Sci 19:141–147CrossRefPubMed
9.
go back to reference Baumgartner JM, Krasinskas A, Daouadi M, et al. (2012) Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic adenocarcinoma following neoadjuvant therapy. J Gastrointest Surg 16:1152–1159CrossRefPubMed Baumgartner JM, Krasinskas A, Daouadi M, et al. (2012) Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic adenocarcinoma following neoadjuvant therapy. J Gastrointest Surg 16:1152–1159CrossRefPubMed
10.
go back to reference Hirano S, Kondo S, Hara T, et al. (2007) Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer: long-term results. Ann Surg 246:46–51CrossRefPubMedPubMedCentral Hirano S, Kondo S, Hara T, et al. (2007) Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer: long-term results. Ann Surg 246:46–51CrossRefPubMedPubMedCentral
11.
go back to reference Gong H, Ma R, Gong J, et al. (2016) Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic cancer: a systematic review and meta-analysis. Medicine ((Baltimore)). doi:10.1097/MD.0000000000003061 Gong H, Ma R, Gong J, et al. (2016) Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic cancer: a systematic review and meta-analysis. Medicine ((Baltimore)). doi:10.​1097/​MD.​0000000000003061​
12.
go back to reference Cesaretti M, Abdel-Rehim M, Barbier L, et al. (2016) Modified Appleby procedure for borderline resectable/locally advanced distal pancreatic adenocarcinoma: a major procedure for selected patients. J Visc Surg 153:173–181CrossRefPubMed Cesaretti M, Abdel-Rehim M, Barbier L, et al. (2016) Modified Appleby procedure for borderline resectable/locally advanced distal pancreatic adenocarcinoma: a major procedure for selected patients. J Visc Surg 153:173–181CrossRefPubMed
13.
go back to reference Wolfgang CL, Corl F, Johnson PT, et al. (2011) Pancreatic surgery for the radiologist, 2011: an illustrated review of classic and newer surgical techniques for pancreatic tumor resection. Am J Roentgenol 197:1343–1350CrossRef Wolfgang CL, Corl F, Johnson PT, et al. (2011) Pancreatic surgery for the radiologist, 2011: an illustrated review of classic and newer surgical techniques for pancreatic tumor resection. Am J Roentgenol 197:1343–1350CrossRef
14.
go back to reference Hirai I, Kimura W, Kamiga M, et al. (2005) The significance of intraoperative Doppler ultrasonography in evaluating hepatic arterial flow when assessing the indications for the Appleby procedure for pancreatic body cancer. J Hepatobiliary Pancreat Surg 12:55–60CrossRefPubMed Hirai I, Kimura W, Kamiga M, et al. (2005) The significance of intraoperative Doppler ultrasonography in evaluating hepatic arterial flow when assessing the indications for the Appleby procedure for pancreatic body cancer. J Hepatobiliary Pancreat Surg 12:55–60CrossRefPubMed
15.
go back to reference Kim SW, Yamaue H (2017) Pancreatic cancer: with special focus on topical issues and surgical techniques. Heidelberg: SpringerCrossRef Kim SW, Yamaue H (2017) Pancreatic cancer: with special focus on topical issues and surgical techniques. Heidelberg: SpringerCrossRef
16.
go back to reference Egorov VI, Petrov RV, Lozhkin MV, et al. (2013) Liver blood supply after a modified Appleby procedure in classical and aberrant arterial anatomy. World J Gastrointest Surg 5:51–61CrossRefPubMedPubMedCentral Egorov VI, Petrov RV, Lozhkin MV, et al. (2013) Liver blood supply after a modified Appleby procedure in classical and aberrant arterial anatomy. World J Gastrointest Surg 5:51–61CrossRefPubMedPubMedCentral
17.
go back to reference Al-Hawary MM, Francis IR, Chari ST, et al. (2014) Pancreatic ductal adenocarcinoma radiology reporting template: consensus statement of the Society of Abdominal Radiology and the American Pancreatic Association. Radiology 270:248–260CrossRefPubMed Al-Hawary MM, Francis IR, Chari ST, et al. (2014) Pancreatic ductal adenocarcinoma radiology reporting template: consensus statement of the Society of Abdominal Radiology and the American Pancreatic Association. Radiology 270:248–260CrossRefPubMed
Metadata
Title
Radiologic evaluation of patients undergoing the modified Appleby procedure for locally advanced pancreatic neoplasms: a case series
Authors
Merel A. T. Vergauwen
Michele Perillo
Alejandro Garces-Descovich
Courtney E. Barrows
A. James Moser
Koenraad J. Mortelé
Publication date
01-02-2018
Publisher
Springer US
Published in
Abdominal Radiology / Issue 2/2018
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-017-1344-8

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