Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Pediatric Radiology
Published in: Pediatric Radiology 5/2013

01-05-2013 | Original Article

Radiologic differences in white matter maturation between preterm and full-term infants: TBSS study

Authors: Ah Young Lee, Sung Ho Jang, Eunsil Lee, Sang Ho Ahn, Hee Kyung Cho, Hae Min Jo, Su Min Son

Published in: Pediatric Radiology | Issue 5/2013

Login to get access

Abstract

Background

Widespread white matter (WM) pathology in preterm children has been proposed.

Objective

The purpose of this study was to investigate maturational differences of WM between preterm infants with thinning of the corpus callosum and full-term infants.

Materials and methods

A total of 18 preterm children and 18 full-term children were divided into three subgroups according to the corrected age at the time of diffusion tensor imaging scanning. Tract-based spatial statistics was used for assessing differences in fractional anisotropy (FA) between preterm and full-term children, and between each age-related subgroup in preterm and in full-term children.

Results

In the preterm group, FA values of overall WM showed an increase with age. This trend indicates that WM maturation is a gradual occurrence during a child’s first 2 years. In the full-term group, most WM structures had reached maturation at around 1 year of age; however, centrum semiovale level showed sustained maturation during the first 2 years.

Conclusion

Results of our study demonstrate radiologic maturational differences of WM and provide evidence of the need for therapeutic intervention within 2 years of birth to prevent specific functional impairment and to improve clinical outcome in preterm children.
Literature
1.
Langhoff-Roos J, Kesmodel U, Jacobsson B et al (2006) Spontaneous preterm delivery in primiparous women at low risk in Denmark: population based study. BMJ 332:937–939PubMedCrossRef
2.
Latal B (2009) Prediction of neurodevelopmental outcome after preterm birth. Pediatr Neurol 40:413–419PubMedCrossRef
3.
Bhutta AT, Cleves MA, Casey PH et al (2002) Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA 288:728–737PubMedCrossRef
4.
van Kooij BJ, de Vries LS, Ball G et al (2012) Neonatal tract-based spatial statistics findings and outcome in preterm infants. AJNR Am J Neuroradiol 33:188–194PubMedCrossRef
5.
Hart AR, Whitby EW, Griffiths PD et al (2008) Magnetic resonance imaging and developmental outcome following preterm birth: review of current evidence. Dev Med Child Neurol 50:655–663PubMedCrossRef
6.
Arzoumanian Y, Mirmiran M, Barnes PD et al (2003) Diffusion tensor brain imaging findings at term-equivalent age may predict neurologic abnormalities in low birth weight preterm infants. AJNR Am J Neuroradiol 24:1646–1653PubMed
7.
Counsell SJ, Boardman JP (2005) Differential brain growth in the infant born preterm: current knowledge and future developments from brain imaging. Semin Fetal Neonatal Med 10:403–410PubMedCrossRef
8.
Anderson NG, Laurent I, Woodward LJ et al (2006) Detection of impaired growth of the corpus callosum in premature infants. Pediatrics 118:951–960PubMedCrossRef
9.
Dudink J, Kerr JL, Paterson K et al (2008) Connecting the developing preterm brain. Early Hum Dev 84:777–782PubMedCrossRef
10.
de Bruine FT, van den Berg-Huysmans AA, Leijser LM et al (2011) Clinical implications of MR imaging findings in the white matter in very preterm infants: a 2-year follow-up study. Radiology 261:899–906PubMedCrossRef
11.
Keshavan MS, Diwadkar VA, DeBellis M et al (2002) Development of the corpus callosum in childhood, adolescence and early adulthood. Life Sci 70:1909–1922PubMedCrossRef
12.
Panigrahy A, Barnes PD, Robertson RL et al (2005) Quantitative analysis of the corpus callosum in children with cerebral palsy and developmental delay: correlation with cerebral white matter volume. Pediatr Radiol 35:1199–1207PubMedCrossRef
13.
Volpe JJ (2003) Cerebral white matter injury of the premature infant-more common than you think. Pediatrics 112(1 Pt 1):176–180PubMedCrossRef
14.
Counsell SJ, Shen Y, Boardman JP et al (2006) Axial and radial diffusivity in preterm infants who have diffuse white matter changes on magnetic resonance imaging at term-equivalent age. Pediatrics 117:376–386PubMedCrossRef
15.
Basser PJ, Pierpaoli C (2011) Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson 213:560–570PubMedCrossRef
16.
Assaf Y, Pasternak O (2008) Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. J Mol Neurosci 34:51–61PubMedCrossRef
17.
Neil JJ (2008) Diffusion imaging concepts for clinicians. J Magn Reson Imagin 27:1–7CrossRef
18.
Dubb A, Gur R, Avants B et al (2003) Characterization of sexual dimorphism in the human corpus callosum. Neuroimage 20:512–519PubMedCrossRef
19.
van Pul C, van Kooij BJ, de Vries LS et al (2012) Quantitative fiber tracking in the corpus callosum and internal capsule reveals microstructural abnormalities in preterm infants at term-equivalent age. AJNR Am J Neuroradiol 33:678–684PubMedCrossRef
20.
Neil JJ, Shiran SI, McKinstry RC et al (1998) Normal brain in human newborns: apparent diffusion coefficient and diffusion anisotropy measured by using diffusion tensor MR imaging. Radiology 209:57–66PubMed
21.
Huppi PS, Maier SE, Peled S et al (1998) Microstructural development of human newborn cerebral white matter assessed in vivo by diffusion tensor magnetic resonance imaging. Pediatr Res 44:584–590PubMedCrossRef
22.
Anjari M, Srinivasan L, Allsop JM et al (2007) Diffusion tensor imaging with tract-based spatial statistics reveals local white matter abnormalities in preterm infants. Neuroimage 35:1021–1027PubMedCrossRef
23.
Giuliani NR, Calhoun VD, Pearlson GD et al (2005) Voxel-based morphometry versus region of interest: a comparison of two methods for analyzing gray matter differences in schizophrenia. Schizophr Res 74:135–147PubMedCrossRef
24.
Kubicki M, Shenton ME, Salisbury DF et al (2002) Voxel-based morphometric analysis of gray matter in first episode schizophrenia. Neuroimage 17:1711–1719PubMedCrossRef
25.
Smith SM, Jenkinson M, Johansen-Berg H et al (2006) Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 31:1487–1505PubMedCrossRef
26.
Inder TE, Wells SJ, Mogridge NB et al (2003) Defining the nature of the cerebral abnormalities in the premature infant: a qualitative magnetic resonance imaging study. J Pediatr 143:171–179PubMedCrossRef
27.
Kier EL, Truwit CL (1996) The normal and abnormal genu of the corpus callosum: an evolutionary, embryologic, anatomic, and MR analysis. AJNR Am J Neuroradiol 17:1631–1641PubMed
28.
Rose SE, Hatzigeorgiou X, Strudwick MW et al (2008) Altered white matter diffusion anisotropy in normal and preterm infants at term-equivalent age. Magn Reson Med 60:761–767PubMedCrossRef
29.
Skiöld B, Horsch S, Hallberg B et al (2010) White matter changes in extremely preterm infants, a population-based diffusion tensor imaging study. Acta Paediatr 99:842–849PubMedCrossRef
30.
van der Knaap MS, Valk J, Barkhof F (2005) Magnetic resonance of myelination and myelin disorders. 3rd edn. Springer, Berlin, New York
31.
Provenzale JM, Liang L, DeLong D et al (2007) Diffusion tensor imaging assessment of brain white matter maturation during the first postnatal year. AJR Am J Radiol 189:476–486
32.
Minkowski A; Council for International Organizations of Medical Sciences (1967) Regional development of the brain in early life: a symposium organized by the Council for International Organizations of Medical Sciences. Blackwell Scientific, Oxford, Edinburgh
33.
Brody BA, Kinney HC, Kloman AS et al (1987) Sequence of central nervous system myelination in human infancy. I. An autopsy study of myelination. J Neuropathol Exp Neurol 46:283–301PubMedCrossRef
34.
Kinney HC, Brody BA, Kloman AS et al (1988) Sequence of central nervous system myelination in human infancy. II. Patterns of myelination in autopsied infants. J Neuropathol Exp Neurol 47:217–234PubMedCrossRef
35.
Barkovich AJ, Kjos BO, Jackson DE Jr et al (1988) Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T. Radiology 166:173–180PubMed
36.
Bird CR, Hedberg M, Drayer BP et al (1989) MR assessment of myelination in infants and children: usefulness of marker sites. AJNR Am J Neuroradiol 10:731–740PubMed
37.
Christophe C, Muller MF, Baleriaux D et al (1990) Mapping of normal brain maturation in infants on phase-sensitive inversion–recovery MR images. Neuroradiology 32:173–178PubMedCrossRef
38.
Pierpaoli C, Jezzard P, Basser PJ et al (1996) Diffusion tensor MR imaging of the human brain. Radiology 201:637–648PubMed
39.
40.
Levitt P (2003) Structural and functional maturation of the developing primate brain. J Pediatr 143:S35–S45PubMedCrossRef
41.
Trivedi R, Agarwal S, Rathore RK et al (2009) Understanding development and lateralization of major cerebral fiber bundles in pediatric population through quantitative diffusion tensor tractography. Pediatr Res 66:636–641PubMedCrossRef
42.
Brooks-Gunn J, McCarton CM, Casey PH et al (1994) Early intervention in low-birth-weight premature infants. Results through age 5 years from the Infant Health and Development Program. JAMA 272:1257–1262PubMedCrossRef
43.
McCarton CM, Wallace IF, Bennett FC (1996) Early intervention for low-birth-weight premature infants: what can we achieve? Ann Med 28:221–225PubMedCrossRef
44.
Melnyk BM, Alpert-Gillis L, Feinstein NF (2001) Improving cognitive development of low-birth-weight premature infants with the COPE program: a pilot study of the benefit of early NICU intervention with mothers. Res Nurse Health 24:373–389CrossRef
45.
Cameron EC, Maehle V, Reid J (2005) The effects of an early physical therapy intervention for very preterm, very low birth weight infants: a randomized controlled clinical trial. Pediatr Phys Ther 17:107–119PubMedCrossRef
46.
Spittle AJ, Orton J, Doyle LW et al (2007) Early developmental intervention programs post hospital discharge to prevent motor and cognitive impairments in preterm infants. Cochrane Database Syst Rev 18:CD005495
Metadata
Title
Radiologic differences in white matter maturation between preterm and full-term infants: TBSS study
Authors
Ah Young Lee
Sung Ho Jang
Eunsil Lee
Sang Ho Ahn
Hee Kyung Cho
Hae Min Jo
Su Min Son
Publication date
01-05-2013
Publisher
Springer-Verlag
Published in
Pediatric Radiology / Issue 5/2013
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-012-2545-5

Other articles of this Issue 5/2013

Pediatric Radiology 5/2013 Go to the issue

Letter to the Editor

Reply to Riccabona et al. regarding screening for developmental dysplasia of the hip

Case Report

Radiological findings of gastric adenomyoma in a neonate presenting with gastric outlet obstruction

Original Article

Percutaneous CT-guided vertebral bone biopsy in children

Original Article

A method to derive appropriate exposure parameters from target exposure index and patient thickness in pediatric digital radiography

Original Article

Characteristic scapular and rib changes on chest radiographs of children with ADA-deficiency SCIDS in the first year of life

Original Article

Efficacy and safety of deep sedation by non-anesthesiologists for cardiac MRI in children