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Published in: Journal of Endocrinological Investigation 9/2016

01-09-2016 | Short Review

Radiofrequency ablation for benign thyroid nodules

Authors: S. Bernardi, F. Stacul, M. Zecchin, C. Dobrinja, F. Zanconati, B. Fabris

Published in: Journal of Endocrinological Investigation | Issue 9/2016

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Abstract

Benign thyroid nodules are an extremely common occurrence. Radiofrequency ablation (RFA) is gaining ground as an effective technique for their treatment, in case they become symptomatic. Here we review what are the current indications to RFA, its outcomes in terms of efficacy, tolerability, and cost, and also how it compares to the other conventional and experimental treatment modalities for benign thyroid nodules. Moreover, we will also address the issue of treating with this technique patients with cardiac pacemakers (PM) or implantable cardioverter-defibrillators (ICD), as it is a rather frequent occurrence that has never been addressed in detail in the literature.
Literature
1.
go back to reference Gnarini VL, Brigante G, Della Valle E, Diazzi C, Madeo B, Carani C, Rochira V, Simoni M (2013) Very high prevalence of ultrasound thyroid scan abnormalities in healthy volunteers in Modena, Italy. J Endocrinol Invest 36:722–728PubMed Gnarini VL, Brigante G, Della Valle E, Diazzi C, Madeo B, Carani C, Rochira V, Simoni M (2013) Very high prevalence of ultrasound thyroid scan abnormalities in healthy volunteers in Modena, Italy. J Endocrinol Invest 36:722–728PubMed
2.
go back to reference Baek JH, Lee JH, Valcavi R, Pacella CM, Rhim H, Na DG (2011) Thermal ablation for benign thyroid nodules: radiofrequency and laser. Korean J Radiol 12:525–540CrossRefPubMedPubMedCentral Baek JH, Lee JH, Valcavi R, Pacella CM, Rhim H, Na DG (2011) Thermal ablation for benign thyroid nodules: radiofrequency and laser. Korean J Radiol 12:525–540CrossRefPubMedPubMedCentral
3.
4.
go back to reference Gharib H, Hegedus L, Pacella CM, Baek JH, Papini E (2013) Clinical review: nonsurgical, image-guided, minimally invasive therapy for thyroid nodules. J Clin Endocrinol Metab 98:3949–3957CrossRefPubMed Gharib H, Hegedus L, Pacella CM, Baek JH, Papini E (2013) Clinical review: nonsurgical, image-guided, minimally invasive therapy for thyroid nodules. J Clin Endocrinol Metab 98:3949–3957CrossRefPubMed
5.
go back to reference Papini E, Pacella CM, Hegedus L (2014) Diagnosis of endocrine disease: thyroid ultrasound (US) and US-assisted procedures: from the shadows into an array of applications. Eur J Endocrinol 170:R133–R146CrossRefPubMed Papini E, Pacella CM, Hegedus L (2014) Diagnosis of endocrine disease: thyroid ultrasound (US) and US-assisted procedures: from the shadows into an array of applications. Eur J Endocrinol 170:R133–R146CrossRefPubMed
6.
go back to reference Lupo MA (2015) Radiofrequency ablation for benign thyroid nodules—a look towards the future of interventional thyroidology. Endocr Pract 21:972–974CrossRefPubMed Lupo MA (2015) Radiofrequency ablation for benign thyroid nodules—a look towards the future of interventional thyroidology. Endocr Pract 21:972–974CrossRefPubMed
7.
go back to reference Perros P, Boelaert K, Colley S, Evans C, Evans RM, Gerrard Ba G, Gilbert J, Harrison B, Johnson SJ, Giles TE, Moss L, Lewington V, Newbold K, Taylor J, Thakker RV, Watkinson J, Williams GR, British Thyroid A (2014) Guidelines for the management of thyroid cancer. Clin Endocrinol (Oxf) 81(Suppl 1):1–122CrossRef Perros P, Boelaert K, Colley S, Evans C, Evans RM, Gerrard Ba G, Gilbert J, Harrison B, Johnson SJ, Giles TE, Moss L, Lewington V, Newbold K, Taylor J, Thakker RV, Watkinson J, Williams GR, British Thyroid A (2014) Guidelines for the management of thyroid cancer. Clin Endocrinol (Oxf) 81(Suppl 1):1–122CrossRef
8.
go back to reference Haugen BRM, Alexander EK, Bible KC, Doherty G, Mandel SJ, Nikiforov YE, Pacini F, Randolph G, Sawka A, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward D, Tuttle RMM, Wartofsky L (2015) 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer. Thyroid 26:1–133 Haugen BRM, Alexander EK, Bible KC, Doherty G, Mandel SJ, Nikiforov YE, Pacini F, Randolph G, Sawka A, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward D, Tuttle RMM, Wartofsky L (2015) 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer. Thyroid 26:1–133
9.
go back to reference Zhao Q, Tian G, Kong D, Jiang T (2016) Meta-analysis of radiofrequency ablation for treating the local recurrence of thyroid cancers. J Endocrinol Invest. doi:10.1007/s40618-016-0450-8 Zhao Q, Tian G, Kong D, Jiang T (2016) Meta-analysis of radiofrequency ablation for treating the local recurrence of thyroid cancers. J Endocrinol Invest. doi:10.​1007/​s40618-016-0450-8
10.
go back to reference Garberoglio R, Aliberti C, Appetecchia M, Attard M, Boccuzzi G, Boraso F, Borretta G, Caruso G, Deandrea M, Freddi M, Gallone G, Gandini G, Gasparri G, Gazzera C, Ghigo E, Grosso M, Limone P, Maccario M, Mansi L, Mormile A, Nasi PG, Orlandi F, Pacchioni D, Pacella CM, Palestini N, Papini E, Pelizzo MR, Piotto A, Rago T, Riganti F, Rosato L, Rossetto R, Scarmozzino A, Spiezia S, Testori O, Valcavi R, Veltri A, Vitti P, Zingrillo M (2015) Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement. J Ultrasound 18:423–430CrossRefPubMed Garberoglio R, Aliberti C, Appetecchia M, Attard M, Boccuzzi G, Boraso F, Borretta G, Caruso G, Deandrea M, Freddi M, Gallone G, Gandini G, Gasparri G, Gazzera C, Ghigo E, Grosso M, Limone P, Maccario M, Mansi L, Mormile A, Nasi PG, Orlandi F, Pacchioni D, Pacella CM, Palestini N, Papini E, Pelizzo MR, Piotto A, Rago T, Riganti F, Rosato L, Rossetto R, Scarmozzino A, Spiezia S, Testori O, Valcavi R, Veltri A, Vitti P, Zingrillo M (2015) Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement. J Ultrasound 18:423–430CrossRefPubMed
11.
go back to reference Bernardi S, Dobrinja C, Fabris B, Bazzocchi G, Sabato N, Ulcigrai V, Giacca M, Barro E, De Manzini N, Stacul F (2014) Radiofrequency ablation compared to surgery for the treatment of benign thyroid nodules. Int J Endocrinol 2014:934595CrossRefPubMedPubMedCentral Bernardi S, Dobrinja C, Fabris B, Bazzocchi G, Sabato N, Ulcigrai V, Giacca M, Barro E, De Manzini N, Stacul F (2014) Radiofrequency ablation compared to surgery for the treatment of benign thyroid nodules. Int J Endocrinol 2014:934595CrossRefPubMedPubMedCentral
12.
go back to reference Dobrinja C, Bernardi S, Fabris B, Eramo R, Makovac P, Bazzocchi G, Piscopello L, Barro E, de Manzini N, Bonazza D, Pinamonti M, Zanconati F, Stacul F (2015) Surgical and Pathological changes after radiofrequency ablation of thyroid nodules. Int J Endocrinol 2015:576576CrossRefPubMedPubMedCentral Dobrinja C, Bernardi S, Fabris B, Eramo R, Makovac P, Bazzocchi G, Piscopello L, Barro E, de Manzini N, Bonazza D, Pinamonti M, Zanconati F, Stacul F (2015) Surgical and Pathological changes after radiofrequency ablation of thyroid nodules. Int J Endocrinol 2015:576576CrossRefPubMedPubMedCentral
13.
go back to reference Bernardi S, Lanzilotti V, Papa G, Panizzo N, Dobrinja C, Fabris B, Stacul F (2015) Full-thickness skin burn caused by radiofrequency ablation of a benign thyroid nodule. Thyroid 26:183–184CrossRefPubMed Bernardi S, Lanzilotti V, Papa G, Panizzo N, Dobrinja C, Fabris B, Stacul F (2015) Full-thickness skin burn caused by radiofrequency ablation of a benign thyroid nodule. Thyroid 26:183–184CrossRefPubMed
14.
go back to reference Kim YS, Rhim H, Tae K, Park DW, Kim ST (2006) Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience. Thyroid 16:361–367CrossRefPubMed Kim YS, Rhim H, Tae K, Park DW, Kim ST (2006) Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience. Thyroid 16:361–367CrossRefPubMed
15.
go back to reference Spiezia S, Garberoglio R, Di Somma C, Deandrea M, Basso E, Limone PP, Milone F, Ramundo V, Macchia PE, Biondi B, Lombardi G, Colao A, Faggiano A (2007) Efficacy and safety of radiofrequency thermal ablation in the treatment of thyroid nodules with pressure symptoms in elderly patients. J Am Geriatr Soc 55:1478–1479CrossRefPubMed Spiezia S, Garberoglio R, Di Somma C, Deandrea M, Basso E, Limone PP, Milone F, Ramundo V, Macchia PE, Biondi B, Lombardi G, Colao A, Faggiano A (2007) Efficacy and safety of radiofrequency thermal ablation in the treatment of thyroid nodules with pressure symptoms in elderly patients. J Am Geriatr Soc 55:1478–1479CrossRefPubMed
16.
go back to reference Deandrea M, Limone P, Basso E, Mormile A, Ragazzoni F, Gamarra E, Spiezia S, Faggiano A, Colao A, Molinari F, Garberoglio R (2008) US-guided percutaneous radiofrequency thermal ablation for the treatment of solid benign hyperfunctioning or compressive thyroid nodules. Ultrasound Med Biol 34:784–791CrossRefPubMed Deandrea M, Limone P, Basso E, Mormile A, Ragazzoni F, Gamarra E, Spiezia S, Faggiano A, Colao A, Molinari F, Garberoglio R (2008) US-guided percutaneous radiofrequency thermal ablation for the treatment of solid benign hyperfunctioning or compressive thyroid nodules. Ultrasound Med Biol 34:784–791CrossRefPubMed
17.
go back to reference Jeong WK, Baek JH, Rhim H, Kim YS, Kwak MS, Jeong HJ, Lee D (2008) Radiofrequency ablation of benign thyroid nodules: safety and imaging follow-up in 236 patients. Eur Radiol 18:1244–1250CrossRefPubMed Jeong WK, Baek JH, Rhim H, Kim YS, Kwak MS, Jeong HJ, Lee D (2008) Radiofrequency ablation of benign thyroid nodules: safety and imaging follow-up in 236 patients. Eur Radiol 18:1244–1250CrossRefPubMed
18.
go back to reference Spiezia S, Garberoglio R, Milone F, Ramundo V, Caiazzo C, Assanti AP, Deandrea M, Limone PP, Macchia PE, Lombardi G, Colao A, Faggiano A (2009) Thyroid nodules and related symptoms are stably controlled two years after radiofrequency thermal ablation. Thyroid 19:219–225CrossRefPubMed Spiezia S, Garberoglio R, Milone F, Ramundo V, Caiazzo C, Assanti AP, Deandrea M, Limone PP, Macchia PE, Lombardi G, Colao A, Faggiano A (2009) Thyroid nodules and related symptoms are stably controlled two years after radiofrequency thermal ablation. Thyroid 19:219–225CrossRefPubMed
19.
go back to reference Baek JH, Kim YS, Lee D, Huh JY, Lee JH (2010) Benign predominantly solid thyroid nodules: prospective study of efficacy of sonographically guided radiofrequency ablation versus control condition. AJR Am J Roentgenol 194:1137–1142CrossRefPubMed Baek JH, Kim YS, Lee D, Huh JY, Lee JH (2010) Benign predominantly solid thyroid nodules: prospective study of efficacy of sonographically guided radiofrequency ablation versus control condition. AJR Am J Roentgenol 194:1137–1142CrossRefPubMed
20.
go back to reference Na DG, Lee JH, Jung SL, Kim JH, Sung JY, Shin JH, Kim EK, Lee JH, Kim DW, Park JS, Kim KS, Baek SM, Lee Y, Chong S, Sim JS, Huh JY, Bae JI, Kim KT, Han SY, Bae MY, Kim YS, Baek JH, Korean Society of Thyroid R, Korean Society of R (2012) Radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers: consensus statement and recommendations. Korean J Radiol 13:117–125CrossRefPubMedPubMedCentral Na DG, Lee JH, Jung SL, Kim JH, Sung JY, Shin JH, Kim EK, Lee JH, Kim DW, Park JS, Kim KS, Baek SM, Lee Y, Chong S, Sim JS, Huh JY, Bae JI, Kim KT, Han SY, Bae MY, Kim YS, Baek JH, Korean Society of Thyroid R, Korean Society of R (2012) Radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers: consensus statement and recommendations. Korean J Radiol 13:117–125CrossRefPubMedPubMedCentral
21.
22.
go back to reference Nardi F, Basolo F, Crescenzi A, Fadda G, Frasoldati A, Orlandi F, Palombini L, Papini E, Zini M, Pontecorvi A, Vitti P (2014) Italian consensus for the classification and reporting of thyroid cytology. J Endocrinol Invest 37:593–599CrossRefPubMed Nardi F, Basolo F, Crescenzi A, Fadda G, Frasoldati A, Orlandi F, Palombini L, Papini E, Zini M, Pontecorvi A, Vitti P (2014) Italian consensus for the classification and reporting of thyroid cytology. J Endocrinol Invest 37:593–599CrossRefPubMed
23.
go back to reference Cibas ES, Ali SZ, Conference NCITFSotS (2009) The Bethesda system for reporting thyroid cytopathology. Am J Clin Pathol 132:658–665CrossRefPubMed Cibas ES, Ali SZ, Conference NCITFSotS (2009) The Bethesda system for reporting thyroid cytopathology. Am J Clin Pathol 132:658–665CrossRefPubMed
24.
go back to reference Wang CC, Friedman L, Kennedy GC, Wang H, Kebebew E, Steward DL, Zeiger MA, Westra WH, Wang Y, Khanafshar E, Fellegara G, Rosai J, Livolsi V, Lanman RB (2011) A large multicenter correlation study of thyroid nodule cytopathology and histopathology. Thyroid 21:243–251CrossRefPubMedPubMedCentral Wang CC, Friedman L, Kennedy GC, Wang H, Kebebew E, Steward DL, Zeiger MA, Westra WH, Wang Y, Khanafshar E, Fellegara G, Rosai J, Livolsi V, Lanman RB (2011) A large multicenter correlation study of thyroid nodule cytopathology and histopathology. Thyroid 21:243–251CrossRefPubMedPubMedCentral
25.
go back to reference Kim HY, Ryu WS, Woo SU, Son GS, Lee ES, Lee JB, Bae JW (2010) Primary papillary thyroid carcinoma previously treated incompletely with radiofrequency ablation. J Cancer Res Ther 6:310–312CrossRefPubMed Kim HY, Ryu WS, Woo SU, Son GS, Lee ES, Lee JB, Bae JW (2010) Primary papillary thyroid carcinoma previously treated incompletely with radiofrequency ablation. J Cancer Res Ther 6:310–312CrossRefPubMed
26.
go back to reference Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof EL, Fleischmann KE, Freeman WK, Froehlich JB, Kasper EK, Kersten JR, Riegel B, Robb JF, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Antman EM, Buller CE, Creager MA, Ettinger SM, Faxon DP, Fuster V, Halperin JL, Hiratzka LF, Hunt SA, Lytle BW, Nishimura R, Ornato JP, Page RL, Riegel B, Tarkington LG, Yancy CW (2007) ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (writing committee to revise the 2002 guidelines on perioperative cardiovascular evaluation for noncardiac surgery) developed in collaboration With the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. J Am Coll Cardiol 50:1707–1732CrossRefPubMed Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof EL, Fleischmann KE, Freeman WK, Froehlich JB, Kasper EK, Kersten JR, Riegel B, Robb JF, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Antman EM, Buller CE, Creager MA, Ettinger SM, Faxon DP, Fuster V, Halperin JL, Hiratzka LF, Hunt SA, Lytle BW, Nishimura R, Ornato JP, Page RL, Riegel B, Tarkington LG, Yancy CW (2007) ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (writing committee to revise the 2002 guidelines on perioperative cardiovascular evaluation for noncardiac surgery) developed in collaboration With the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. J Am Coll Cardiol 50:1707–1732CrossRefPubMed
27.
go back to reference American Society of Anesthesiologists Task Force on perioperative management of patients with cardiac rhythm management D (2005) Practice advisory for the perioperative management of patients with cardiac rhythm management devices: pacemakers and implantable cardioverter-defibrillators: a report by the American Society of Anesthesiologists Task Force on perioperative management of patients with cardiac rhythm management devices. Anesthesiology 103:186–198CrossRef American Society of Anesthesiologists Task Force on perioperative management of patients with cardiac rhythm management D (2005) Practice advisory for the perioperative management of patients with cardiac rhythm management devices: pacemakers and implantable cardioverter-defibrillators: a report by the American Society of Anesthesiologists Task Force on perioperative management of patients with cardiac rhythm management devices. Anesthesiology 103:186–198CrossRef
28.
go back to reference Tong NY, Ru HJ, Ling HY, Cheung YC, Meng LW, Chung PC (2004) Extracardiac radiofrequency ablation interferes with pacemaker function but does not damage the device. Anesthesiology 100:1041CrossRefPubMed Tong NY, Ru HJ, Ling HY, Cheung YC, Meng LW, Chung PC (2004) Extracardiac radiofrequency ablation interferes with pacemaker function but does not damage the device. Anesthesiology 100:1041CrossRefPubMed
29.
go back to reference Pfeiffer D, Tebbenjohanns J, Schumacher B, Jung W, Luderitz B (1995) Pacemaker function during radiofrequency ablation. Pacing Clin Electrophysiol 18:1037–1044CrossRefPubMed Pfeiffer D, Tebbenjohanns J, Schumacher B, Jung W, Luderitz B (1995) Pacemaker function during radiofrequency ablation. Pacing Clin Electrophysiol 18:1037–1044CrossRefPubMed
30.
go back to reference Hayes DL, Charboneau JW, Lewis BD, Asirvatham SJ, Dupuy DE, Lexvold NY (2001) Radiofrequency treatment of hepatic neoplasms in patients with permanent pacemakers. Mayo Clin Proc 76:950–952CrossRefPubMed Hayes DL, Charboneau JW, Lewis BD, Asirvatham SJ, Dupuy DE, Lexvold NY (2001) Radiofrequency treatment of hepatic neoplasms in patients with permanent pacemakers. Mayo Clin Proc 76:950–952CrossRefPubMed
31.
go back to reference Crossley GH, Poole JE, Rozner MA, Asirvatham SJ, Cheng A, Chung MK, Ferguson TB Jr, Gallagher JD, Gold MR, Hoyt RH, Irefin S, Kusumoto FM, Moorman LP, Thompson A (2011) The Heart Rhythm Society (HRS)/American Society of Anesthesiologists (ASA) expert consensus statement on the perioperative management of patients with implantable defibrillators, pacemakers and arrhythmia monitors: facilities and patient management this document was developed as a joint project with the American Society of Anesthesiologists (ASA), and in collaboration with the American Heart Association (AHA), and the Society of Thoracic Surgeons (STS). Heart Rhythm 8:1114–1154CrossRefPubMed Crossley GH, Poole JE, Rozner MA, Asirvatham SJ, Cheng A, Chung MK, Ferguson TB Jr, Gallagher JD, Gold MR, Hoyt RH, Irefin S, Kusumoto FM, Moorman LP, Thompson A (2011) The Heart Rhythm Society (HRS)/American Society of Anesthesiologists (ASA) expert consensus statement on the perioperative management of patients with implantable defibrillators, pacemakers and arrhythmia monitors: facilities and patient management this document was developed as a joint project with the American Society of Anesthesiologists (ASA), and in collaboration with the American Heart Association (AHA), and the Society of Thoracic Surgeons (STS). Heart Rhythm 8:1114–1154CrossRefPubMed
32.
go back to reference Faggiano A, Ramundo V, Assanti AP, Fonderico F, Macchia PE, Misso C, Marciello F, Marotta V, Del Prete M, Papini E, Lombardi G, Colao A, Spiezia S (2012) Thyroid nodules treated with percutaneous radiofrequency thermal ablation: a comparative study. J Clin Endocrinol Metab 97:4439–4445CrossRefPubMed Faggiano A, Ramundo V, Assanti AP, Fonderico F, Macchia PE, Misso C, Marciello F, Marotta V, Del Prete M, Papini E, Lombardi G, Colao A, Spiezia S (2012) Thyroid nodules treated with percutaneous radiofrequency thermal ablation: a comparative study. J Clin Endocrinol Metab 97:4439–4445CrossRefPubMed
33.
go back to reference Deandrea M, Sung JY, Limone P, Mormile A, Garino F, Ragazzoni F, Kim KS, Lee D, Baek JH (2015) Efficacy and safety of radiofrequency ablation versus observation for nonfunctioning benign thyroid nodules: a randomized controlled international collaborative trial. Thyroid 25:890–896CrossRefPubMed Deandrea M, Sung JY, Limone P, Mormile A, Garino F, Ragazzoni F, Kim KS, Lee D, Baek JH (2015) Efficacy and safety of radiofrequency ablation versus observation for nonfunctioning benign thyroid nodules: a randomized controlled international collaborative trial. Thyroid 25:890–896CrossRefPubMed
34.
go back to reference Valcavi R, Tsamatropoulos P (2015) Health-related quality of life after percutaneous radiofrequency ablation of cold, solid, benign thyroid nodules: a 2-Year follow-up study in 40 patients. Endocr Pract 21:887–896CrossRefPubMed Valcavi R, Tsamatropoulos P (2015) Health-related quality of life after percutaneous radiofrequency ablation of cold, solid, benign thyroid nodules: a 2-Year follow-up study in 40 patients. Endocr Pract 21:887–896CrossRefPubMed
35.
go back to reference Lim HK, Lee JH, Ha EJ, Sung JY, Kim JK, Baek JH (2013) Radiofrequency ablation of benign non-functioning thyroid nodules: 4-year follow-up results for 111 patients. Eur Radiol 23:1044–1049CrossRefPubMed Lim HK, Lee JH, Ha EJ, Sung JY, Kim JK, Baek JH (2013) Radiofrequency ablation of benign non-functioning thyroid nodules: 4-year follow-up results for 111 patients. Eur Radiol 23:1044–1049CrossRefPubMed
36.
go back to reference Lee JH, Kim YS, Lee D, Choi H, Yoo H, Baek JH (2010) Radiofrequency ablation (RFA) of benign thyroid nodules in patients with incompletely resolved clinical problems after ethanol ablation (EA). World J Surg 34:1488–1493CrossRefPubMed Lee JH, Kim YS, Lee D, Choi H, Yoo H, Baek JH (2010) Radiofrequency ablation (RFA) of benign thyroid nodules in patients with incompletely resolved clinical problems after ethanol ablation (EA). World J Surg 34:1488–1493CrossRefPubMed
37.
go back to reference Sung JY, Kim YS, Choi H, Lee JH, Baek JH (2011) Optimum first-line treatment technique for benign cystic thyroid nodules: ethanol ablation or radiofrequency ablation? AJR Am J Roentgenol 196:W210–W214CrossRefPubMed Sung JY, Kim YS, Choi H, Lee JH, Baek JH (2011) Optimum first-line treatment technique for benign cystic thyroid nodules: ethanol ablation or radiofrequency ablation? AJR Am J Roentgenol 196:W210–W214CrossRefPubMed
38.
go back to reference Sung JY, Baek JH, Kim KS, Lee D, Yoo H, Kim JK, Park SH (2013) Single-session treatment of benign cystic thyroid nodules with ethanol versus radiofrequency ablation: a prospective randomized study. Radiology 269:293–300CrossRefPubMed Sung JY, Baek JH, Kim KS, Lee D, Yoo H, Kim JK, Park SH (2013) Single-session treatment of benign cystic thyroid nodules with ethanol versus radiofrequency ablation: a prospective randomized study. Radiology 269:293–300CrossRefPubMed
39.
go back to reference Baek JH, Moon WJ, Kim YS, Lee JH, Lee D (2009) Radiofrequency ablation for the treatment of autonomously functioning thyroid nodules. World J Surg 33:1971–1977CrossRefPubMed Baek JH, Moon WJ, Kim YS, Lee JH, Lee D (2009) Radiofrequency ablation for the treatment of autonomously functioning thyroid nodules. World J Surg 33:1971–1977CrossRefPubMed
40.
go back to reference Huh JY, Baek JH, Choi H, Kim JK, Lee JH (2012) Symptomatic benign thyroid nodules: efficacy of additional radiofrequency ablation treatment session—prospective randomized study. Radiology 263:909–916CrossRefPubMed Huh JY, Baek JH, Choi H, Kim JK, Lee JH (2012) Symptomatic benign thyroid nodules: efficacy of additional radiofrequency ablation treatment session—prospective randomized study. Radiology 263:909–916CrossRefPubMed
41.
go back to reference Baek JH, Lee JH, Sung JY, Bae JI, Kim KT, Sim J, Baek SM, Kim YS, Shin JH, Park JS, Kim DW, Kim JH, Kim EK, Jung SL, Na DG, Korean Society of Thyroid R (2012) Complications encountered in the treatment of benign thyroid nodules with US-guided radiofrequency ablation: a multicenter study. Radiology 262:335–342CrossRefPubMed Baek JH, Lee JH, Sung JY, Bae JI, Kim KT, Sim J, Baek SM, Kim YS, Shin JH, Park JS, Kim DW, Kim JH, Kim EK, Jung SL, Na DG, Korean Society of Thyroid R (2012) Complications encountered in the treatment of benign thyroid nodules with US-guided radiofrequency ablation: a multicenter study. Radiology 262:335–342CrossRefPubMed
42.
go back to reference Shin JH, Jung SL, Baek JH, Kim JH (2011) Rupture of benign thyroid tumors after radio-frequency ablation. AJNR Am J Neuroradiol 32:2165–2169CrossRefPubMed Shin JH, Jung SL, Baek JH, Kim JH (2011) Rupture of benign thyroid tumors after radio-frequency ablation. AJNR Am J Neuroradiol 32:2165–2169CrossRefPubMed
43.
go back to reference Kobayashi A, Kuma K, Matsuzuka F, Hirai K, Fukata S, Sugawara M (1992) Thyrotoxicosis after needle aspiration of thyroid cyst. J Clin Endocrinol Metab 75:21–24PubMed Kobayashi A, Kuma K, Matsuzuka F, Hirai K, Fukata S, Sugawara M (1992) Thyrotoxicosis after needle aspiration of thyroid cyst. J Clin Endocrinol Metab 75:21–24PubMed
44.
go back to reference Che Y, Jin S, Shi C, Wang L, Zhang X, Li Y, Baek JH (2015) Treatment of Benign thyroid nodules: comparison of surgery with radiofrequency ablation. AJNR Am J Neuroradiol 36:1321–1325CrossRefPubMed Che Y, Jin S, Shi C, Wang L, Zhang X, Li Y, Baek JH (2015) Treatment of Benign thyroid nodules: comparison of surgery with radiofrequency ablation. AJNR Am J Neuroradiol 36:1321–1325CrossRefPubMed
45.
go back to reference Ferrari C, Reschini E, Paracchi A (1996) Treatment of the autonomous thyroid nodule: a review. Eur J Endocrinol 135:383–390CrossRefPubMed Ferrari C, Reschini E, Paracchi A (1996) Treatment of the autonomous thyroid nodule: a review. Eur J Endocrinol 135:383–390CrossRefPubMed
46.
go back to reference Nygaard B, Hegedus L, Nielsen KG, Ulriksen P, Hansen JM (1999) Long-term effect of radioactive iodine on thyroid function and size in patients with solitary autonomously functioning toxic thyroid nodules. Clin Endocrinol (Oxf) 50:197–202CrossRef Nygaard B, Hegedus L, Nielsen KG, Ulriksen P, Hansen JM (1999) Long-term effect of radioactive iodine on thyroid function and size in patients with solitary autonomously functioning toxic thyroid nodules. Clin Endocrinol (Oxf) 50:197–202CrossRef
47.
go back to reference Ceccarelli C, Bencivelli W, Vitti P, Grasso L, Pinchera A (2005) Outcome of radioiodine-131 therapy in hyperfunctioning thyroid nodules: a 20 years’ retrospective study. Clin Endocrinol (Oxf) 62:331–335CrossRef Ceccarelli C, Bencivelli W, Vitti P, Grasso L, Pinchera A (2005) Outcome of radioiodine-131 therapy in hyperfunctioning thyroid nodules: a 20 years’ retrospective study. Clin Endocrinol (Oxf) 62:331–335CrossRef
49.
go back to reference Chianelli M, Bizzarri G, Todino V, Misischi I, Bianchini A, Graziano F, Guglielmi R, Pacella CM, Gharib H, Papini E (2014) Laser ablation and 131-iodine: a 24-month pilot study of combined treatment for large toxic nodular goiter. J Clin Endocrinol Metab 99:E1283–E1286CrossRefPubMed Chianelli M, Bizzarri G, Todino V, Misischi I, Bianchini A, Graziano F, Guglielmi R, Pacella CM, Gharib H, Papini E (2014) Laser ablation and 131-iodine: a 24-month pilot study of combined treatment for large toxic nodular goiter. J Clin Endocrinol Metab 99:E1283–E1286CrossRefPubMed
50.
go back to reference Gharib H, Papini E, Valcavi R, Baskin HJ, Crescenzi A, Dottorini ME, Duick DS, Guglielmi R, Hamilton CR Jr, Zeiger MA, Zini M, Nodules AATFoT (2006) American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr Pract 12:63–102CrossRefPubMed Gharib H, Papini E, Valcavi R, Baskin HJ, Crescenzi A, Dottorini ME, Duick DS, Guglielmi R, Hamilton CR Jr, Zeiger MA, Zini M, Nodules AATFoT (2006) American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr Pract 12:63–102CrossRefPubMed
51.
go back to reference La Rosa GL, Lupo L, Giuffrida D, Gullo D, Vigneri R, Belfiore A (1995) Levothyroxine and potassium iodide are both effective in treating benign solitary solid cold nodules of the thyroid. Ann Intern Med 122:1–8CrossRefPubMed La Rosa GL, Lupo L, Giuffrida D, Gullo D, Vigneri R, Belfiore A (1995) Levothyroxine and potassium iodide are both effective in treating benign solitary solid cold nodules of the thyroid. Ann Intern Med 122:1–8CrossRefPubMed
52.
go back to reference Zelmanovitz F, Genro S, Gross JL (1998) Suppressive therapy with levothyroxine for solitary thyroid nodules: a double-blind controlled clinical study and cumulative meta-analyses. J Clin Endocrinol Metab 83:3881–3885PubMed Zelmanovitz F, Genro S, Gross JL (1998) Suppressive therapy with levothyroxine for solitary thyroid nodules: a double-blind controlled clinical study and cumulative meta-analyses. J Clin Endocrinol Metab 83:3881–3885PubMed
53.
go back to reference Wemeau JL, Caron P, Schvartz C, Schlienger JL, Orgiazzi J, Cousty C, Vlaeminck-Guillem V (2002) Effects of thyroid-stimulating hormone suppression with levothyroxine in reducing the volume of solitary thyroid nodules and improving extranodular nonpalpable changes: a randomized, double-blind, placebo-controlled trial by the French Thyroid Research Group. J Clin Endocrinol Metab 87:4928–4934CrossRefPubMed Wemeau JL, Caron P, Schvartz C, Schlienger JL, Orgiazzi J, Cousty C, Vlaeminck-Guillem V (2002) Effects of thyroid-stimulating hormone suppression with levothyroxine in reducing the volume of solitary thyroid nodules and improving extranodular nonpalpable changes: a randomized, double-blind, placebo-controlled trial by the French Thyroid Research Group. J Clin Endocrinol Metab 87:4928–4934CrossRefPubMed
54.
go back to reference Castro MR, Caraballo PJ, Morris JC (2002) Effectiveness of thyroid hormone suppressive therapy in benign solitary thyroid nodules: a meta-analysis. J Clin Endocrinol Metab 87:4154–4159CrossRefPubMed Castro MR, Caraballo PJ, Morris JC (2002) Effectiveness of thyroid hormone suppressive therapy in benign solitary thyroid nodules: a meta-analysis. J Clin Endocrinol Metab 87:4154–4159CrossRefPubMed
55.
go back to reference Puzziello A, Carrano M, Angrisani E, Marotta V, Faggiano A, Zeppa P, Vitale M (2014) Evolution of benign thyroid nodules under levothyroxine non-suppressive therapy. J Endocrinol Invest 37:1181–1186CrossRefPubMed Puzziello A, Carrano M, Angrisani E, Marotta V, Faggiano A, Zeppa P, Vitale M (2014) Evolution of benign thyroid nodules under levothyroxine non-suppressive therapy. J Endocrinol Invest 37:1181–1186CrossRefPubMed
56.
go back to reference Knobel M (2016) Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters. J Endocrinol Invest 39:357–373CrossRefPubMed Knobel M (2016) Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters. J Endocrinol Invest 39:357–373CrossRefPubMed
57.
go back to reference Bandeira-Echtler E, Bergerhoff K, Richter B (2014) Levothyroxine or minimally invasive therapies for benign thyroid nodules. Cochrane Database Syst Rev 6:CD004098PubMed Bandeira-Echtler E, Bergerhoff K, Richter B (2014) Levothyroxine or minimally invasive therapies for benign thyroid nodules. Cochrane Database Syst Rev 6:CD004098PubMed
58.
go back to reference Rozman B, Bence-Zigman Z, Tomic-Brzac H, Skreb F, Pavlinovic Z, Simonovic I (1989) Slerosation of thyroid cysts by ethanol. Period Biol 91:1116–1118 Rozman B, Bence-Zigman Z, Tomic-Brzac H, Skreb F, Pavlinovic Z, Simonovic I (1989) Slerosation of thyroid cysts by ethanol. Period Biol 91:1116–1118
59.
go back to reference Baskin HJ, Duic DS, Levine RA (2013) Thyroid ultrasound and ultrasound-guided FNA, 3rd edn. Springer, BerlinCrossRef Baskin HJ, Duic DS, Levine RA (2013) Thyroid ultrasound and ultrasound-guided FNA, 3rd edn. Springer, BerlinCrossRef
60.
go back to reference Ha EJ, Baek JH, Kim KW, Pyo J, Lee JH, Baek SH, Dossing H, Hegedus L (2015) Comparative efficacy of radiofrequency and laser ablation for the treatment of benign thyroid nodules: systematic review including traditional pooling and bayesian network meta-analysis. J Clin Endocrinol Metab 100:1903–1911CrossRefPubMed Ha EJ, Baek JH, Kim KW, Pyo J, Lee JH, Baek SH, Dossing H, Hegedus L (2015) Comparative efficacy of radiofrequency and laser ablation for the treatment of benign thyroid nodules: systematic review including traditional pooling and bayesian network meta-analysis. J Clin Endocrinol Metab 100:1903–1911CrossRefPubMed
61.
go back to reference Valcavi R, Riganti F, Bertani A, Formisano D, Pacella CM (2010) Percutaneous laser ablation of cold benign thyroid nodules: a 3-year follow-up study in 122 patients. Thyroid 20:1253–1261CrossRefPubMed Valcavi R, Riganti F, Bertani A, Formisano D, Pacella CM (2010) Percutaneous laser ablation of cold benign thyroid nodules: a 3-year follow-up study in 122 patients. Thyroid 20:1253–1261CrossRefPubMed
62.
go back to reference Jang SW, Baek JH, Kim JK, Sung JY, Choi H, Lim HK, Park JW, Lee HY, Park S, Lee JH (2012) How to manage the patients with unsatisfactory results after ethanol ablation for thyroid nodules: role of radiofrequency ablation. Eur J Radiol 81:905–910CrossRefPubMed Jang SW, Baek JH, Kim JK, Sung JY, Choi H, Lim HK, Park JW, Lee HY, Park S, Lee JH (2012) How to manage the patients with unsatisfactory results after ethanol ablation for thyroid nodules: role of radiofrequency ablation. Eur J Radiol 81:905–910CrossRefPubMed
63.
go back to reference Ha EJ, Baek JH, Lee JH, Sung JY, Lee D, Kim JK, Shong YK (2013) Radiofrequency ablation of benign thyroid nodules does not affect thyroid function in patients with previous lobectomy. Thyroid 23:289–293CrossRefPubMed Ha EJ, Baek JH, Lee JH, Sung JY, Lee D, Kim JK, Shong YK (2013) Radiofrequency ablation of benign thyroid nodules does not affect thyroid function in patients with previous lobectomy. Thyroid 23:289–293CrossRefPubMed
64.
go back to reference Sung JY, Baek JH, Jung SL, Kim J, Kim KS, Lee D, Kim WB, Na DG (2015) Radiofrequency ablation for autonomously functioning thyroid nodules: a multicenter study. Thyroid 25:112–117CrossRef Sung JY, Baek JH, Jung SL, Kim J, Kim KS, Lee D, Kim WB, Na DG (2015) Radiofrequency ablation for autonomously functioning thyroid nodules: a multicenter study. Thyroid 25:112–117CrossRef
Metadata
Title
Radiofrequency ablation for benign thyroid nodules
Authors
S. Bernardi
F. Stacul
M. Zecchin
C. Dobrinja
F. Zanconati
B. Fabris
Publication date
01-09-2016
Publisher
Springer International Publishing
Published in
Journal of Endocrinological Investigation / Issue 9/2016
Electronic ISSN: 1720-8386
DOI
https://doi.org/10.1007/s40618-016-0469-x

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