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European Radiology
Published in: European Radiology 7/2019

01-07-2019 | Cardiac

Quantification of myocardial deformation by deformable registration–based analysis of cine MRI: validation with tagged CMR

Authors: Mariana M. Lamacie, Christian P. Houbois, Andreas Greiser, Marie-Pierre Jolly, Paaladinesh Thavendiranathan, Bernd J. Wintersperger

Published in: European Radiology | Issue 7/2019

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Abstract

Objectives

To validate deformable registration algorithms (DRAs) for cine balanced steady-state free precession (bSSFP) assessment of global longitudinal strain (GLS) and global circumferential strain (GCS) using harmonic phase (HARP) cardiovascular magnetic resonance as standard of reference (SoR).

Methods

Seventeen patients and 17 volunteers underwent short axis stack and 2-/4-chamber cine bSSFP imaging with matching slice long-axis and mid-ventricular spatial modulation of magnetization (SPAMM) myocardial tagging. Inverse DRA was applied on bSSFP data for assessment of GLS and GCS while myocardial tagging was processed using HARP. Intra- and inter-observer variability assessment was based on repeated analysis by a single observer and analysis by a second observer, respectively. Standard semi-automated short axis stack segmentation was performed for analysis of left ventricular (LV) volumes and ejection fraction (EF).

Results

DRA demonstrated strong relationships to HARP for myocardial GLS (R2 = 0.75; p < 0.0001) and endocardial GLS (R2 = 0.61; p < 0.0001). GCS result comparison also demonstrated significant relationships between DRA and HARP for myocardial strain (R2 = 0.61; p < 0.0001) and endocardial strain (R2 = 0.51; p < 0.0001). Both methods demonstrated small systematic errors for intra- and inter-observer variability but DRA demonstrated consistently lower CV. Global LVEF was significantly lower (p = 0.0099) in patients (53.7%; IQR 43.9/64.0%) than in healthy volunteers (62.6%; IQR 61.1/66.2%). DRA and HARP strain data demonstrated significant relationships to LVEF.

Conclusions

Non-rigid deformation method–based DRA provides a reliable measure of peak systolic GCS and GLS based on cine bSSFP with superior intra- and inter-observer reproducibility compared to HARP.

Key Point

• Myocardial strain can be reliably analyzed using inverse deformable registration algorithms (DRAs) on cine CMR.
• Inverse DRA-derived strain shows higher reproducibility than tagged CMR.
• DRA and tagged CMR-based myocardial strain demonstrate strong relationships to global left ventricular function.
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Metadata
Title
Quantification of myocardial deformation by deformable registration–based analysis of cine MRI: validation with tagged CMR
Authors
Mariana M. Lamacie
Christian P. Houbois
Andreas Greiser
Marie-Pierre Jolly
Paaladinesh Thavendiranathan
Bernd J. Wintersperger
Publication date
01-07-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 7/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06019-9

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