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Current Oncology Reports
Published in: Current Oncology Reports 2/2019

01-02-2019 | Pyrvinium | Evolving Therapies (RM Bukowski, Section Editor)

Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics

Authors: Jerry Harb, Pen-Jen Lin, Jijun Hao

Published in: Current Oncology Reports | Issue 2/2019

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Abstract

Purpose of Review

Review current understanding of both canonical and non-canonical Wnt signaling in cancer and provide updated knowledge in current clinical trials of Wnt signaling drugs.

Recent Findings

Important roles of both canonical and non-canonical Wnt signaling in cancer have been increasingly recognized. Recent clinical trials of several Wnt-signaling drugs have showed promising outcomes. In addition, some drugs that were originally approved for the treatment of other diseases have been recently found to block Wnt signaling, highlighting their potential to treat Wnt-dependent cancer.

Summary

Dysfunction of Wnt signaling is implicated in cancer, and targeting Wnt signaling represents a useful approach to treat cancer. Current clinical trials of Wnt signaling drugs have showed promising outcomes, and repurposing the previously approved drugs for other diseases to treat Wnt-dependent cancer requires further studies.
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Metadata
Title
Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics
Authors
Jerry Harb
Pen-Jen Lin
Jijun Hao
Publication date
01-02-2019
Publisher
Springer US
Keyword
Pyrvinium
Published in
Current Oncology Reports / Issue 2/2019
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-019-0763-9

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