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Published in: Respiratory Research 1/2017

Open Access 01-12-2017 | Review

WNT signaling – lung cancer is no exception

Authors: Judit Rapp, Luca Jaromi, Krisztian Kvell, Gyorgy Miskei, Judit E. Pongracz

Published in: Respiratory Research | Issue 1/2017

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Abstract

Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the complex roles for WNT signaling pathways in lung cancers has increased substantially. In the current review, the various effects of activation and inhibition of the WNT signaling pathways are summarized in the context of lung carcinogenesis. Recent evidence regarding WNT ligand transport mechanisms, the role of WNT signaling in lung cancer angiogenesis and drug transporter regulation and the importance of microRNA and posttranscriptional regulation of WNT signaling are also reviewed.
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Metadata
Title
WNT signaling – lung cancer is no exception
Authors
Judit Rapp
Luca Jaromi
Krisztian Kvell
Gyorgy Miskei
Judit E. Pongracz
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2017
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-017-0650-6

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