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Surgery Today

15-04-2024 | Pulmonary Hypertension | Original Article

Effect of revised organ transplant law in Japan on lung transplantation

Authors: Yoshito Imamura, Daisuke Nakajima, Takashi Kanou, Yasushi Shintani, Seiichiro Sugimoto, Shinichi Toyooka, Yasushi Hoshikawa, Keitaro Matsumoto, Takeshi Nagayasu, Hidemi Suzuki, Sumiko Maeda, Masayuki Chida, Takeshi Shiraishi, Toshihiko Sato, Masaaki Sato, Jun Nakajima, Hisashi Oishi, Yoshinori Okada, Hiroshi Date

Published in: Surgery Today

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Abstract

Purpose

To investigate how revision of the organ transplant law in Japan affected lung transplantation in this country.

Methods

Lung transplant candidates registered between January, 2000 and December, 2009 were designated as the pre-revision group (n = 396) and those registered between January, 2011 and December, 2020, as the post-revision group (n = 1326). Both groups were analyzed retrospectively using data collected by the Japanese Society of Lung and Heart–Lung Transplantation.

Results

The number of patients who underwent brain-dead donor lung transplantation (BDLT) increased significantly after the law amendment (32.2 vs. 13.8%, p < 0.01). The median waiting time for BDLT was significantly reduced (708 days vs. 1163 days, p < 0.01) and the mortality rate while waiting for BDLT improved significantly after the law amendment (33.1 vs. 42.6%, p < 0.01). In the post-revision group, 18 pediatric patients underwent BDLT. The 5-year survival rates after BDLT were comparable between the groups (73.5% in the pre-revision group vs. 73.2% in the post-revision group, p = 0.32).

Conclusions

The organ transplant law revision shortened the waiting time for BDLT significantly and decreased the mortality rate while waiting for BDLT. The posttransplant outcomes in Japan remained favorable throughout the study period.
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Metadata
Title
Effect of revised organ transplant law in Japan on lung transplantation
Authors
Yoshito Imamura
Daisuke Nakajima
Takashi Kanou
Yasushi Shintani
Seiichiro Sugimoto
Shinichi Toyooka
Yasushi Hoshikawa
Keitaro Matsumoto
Takeshi Nagayasu
Hidemi Suzuki
Sumiko Maeda
Masayuki Chida
Takeshi Shiraishi
Toshihiko Sato
Masaaki Sato
Jun Nakajima
Hisashi Oishi
Yoshinori Okada
Hiroshi Date
Publication date
15-04-2024
Publisher
Springer Nature Singapore
Published in
Surgery Today
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-024-02839-5