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Sleep and Breathing
Published in: Sleep and Breathing 4/2022

13-01-2022 | Pulmonary-Function Tests | Sleep Breathing Physiology and Disorders • Original Article

Sleep-related hypoventilation and hypercapnia in multiple system atrophy detected by polysomnography with transcutaneous carbon dioxide monitoring

Authors: Atsuhiko Sugiyama, Jiro Terada, Yu Shionoya, Shigeki Hirano, Tatsuya Yamamoto, Yoshitaka Yamanaka, Nobuyuki Araki, Ken Koshikawa, Hajime Kasai, Shinobu Ikeda, Jiaqi Wang, Kyosuke Koide, Shoichi Ito, Satoshi Kuwabara

Published in: Sleep and Breathing | Issue 4/2022

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Abstract

Purpose

We aimed to evaluate sleep-related hypoventilation in multiple system atrophy (MSA) using polysomnography (PSG) with transcutaneous partial pressure of carbon dioxide (PtcCO2) monitoring.

Methods

This prospective study included 34 patients with MSA. Motor and autonomic function, neuropsychological tests, PSG with PtcCO2 monitoring, and pulmonary function tests were performed. Sleep-related hypoventilation disorder (SRHD) was defined according to the International Classification of Sleep Disorders, third edition.

Results

Nine (27%) of the 34 patients met the diagnostic criteria of SRHD. Twenty-nine (85%) patients had sleep-related breathing disorders based on an Apnea–Hypopnea Index of ≥ 5/h. The patients with MSA and SRHD had a higher arousal index (p = 0.017) and obstructive apnea index (p = 0.041) than those without SRHD. There was no difference in the daytime partial pressure of carbon dioxide in arterial blood or respiratory function between MSA patients with and without SRHD.

Conclusion

Sleep-related hypoventilation may occur in patients with MSA even with a normal daytime partial pressure of carbon dioxide. This can be noninvasively detected by PSG with PtcCO2 monitoring. SRBD and sleep-related hypoventilation are common among patients with MSA, and clinicians should take this into consideration while evaluating and treating this population.
Appendix
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Metadata
Title
Sleep-related hypoventilation and hypercapnia in multiple system atrophy detected by polysomnography with transcutaneous carbon dioxide monitoring
Authors
Atsuhiko Sugiyama
Jiro Terada
Yu Shionoya
Shigeki Hirano
Tatsuya Yamamoto
Yoshitaka Yamanaka
Nobuyuki Araki
Ken Koshikawa
Hajime Kasai
Shinobu Ikeda
Jiaqi Wang
Kyosuke Koide
Shoichi Ito
Satoshi Kuwabara
Publication date
13-01-2022
Publisher
Springer International Publishing
Published in
Sleep and Breathing / Issue 4/2022
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-022-02568-4

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