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Published in: Indian Journal of Pediatrics 9/2014

01-09-2014 | Clinical Brief

Pulmonary Alveolar Proteinosis Secondary to Pneumocystis jiroveci Infection in an Infant with Common Variable Immunodeficiency

Authors: Dinesh Raj, Tsultem Doma Bhutia, Sandeep Mathur, Sushil Kumar Kabra, Rakesh Lodha

Published in: Indian Journal of Pediatrics | Issue 9/2014

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Abstract

The authors report an infant with common variable immunodeficiency (CVID) with Pneumocystis pneumonia who developed secondary pulmonary alveolar proteinosis (PAP). This is the youngest infant reported to develop PAP secondary to Pneumocystis infection in an immunocompromised state. He was effectively managed with anti-microbials, frequent lung toilet, optimized mechanical ventilation, and supportive care.
Literature
1.
go back to reference Rosen SH, Castleman B, Liebow AA. Pulmonary alveolar proteinosis. N Engl J Med. 1958;258:1123–42.PubMedCrossRef Rosen SH, Castleman B, Liebow AA. Pulmonary alveolar proteinosis. N Engl J Med. 1958;258:1123–42.PubMedCrossRef
2.
go back to reference Tran Van Nhieu J, Vojtek AM, Bernaudin JF, Escudier E, Fleury-Feith J. Pulmonary alveolar proteinosis associated with Pneumocystis carinii. Ultrastructural identification in bronchoalveolar lavage in AIDS and immunocompromised non-AIDS patients. Chest. 1990;98:801–5.PubMedCrossRef Tran Van Nhieu J, Vojtek AM, Bernaudin JF, Escudier E, Fleury-Feith J. Pulmonary alveolar proteinosis associated with Pneumocystis carinii. Ultrastructural identification in bronchoalveolar lavage in AIDS and immunocompromised non-AIDS patients. Chest. 1990;98:801–5.PubMedCrossRef
3.
go back to reference Yong PF, Thaventhiran JE, Grimbacher B. “A rose is a rose is a rose,” but CVID is not CVID common variable immune deficiency (CVID), what do we know in 2011? Adv Immunol. 2011;111:47–107.PubMedCrossRef Yong PF, Thaventhiran JE, Grimbacher B. “A rose is a rose is a rose,” but CVID is not CVID common variable immune deficiency (CVID), what do we know in 2011? Adv Immunol. 2011;111:47–107.PubMedCrossRef
4.
go back to reference Huizar I, Kavuru MS. Alveolar proteinosis syndrome: Pathogenesis, diagnosis, and management. Curr Opin Pulm Med. 2009;15:491–8. Huizar I, Kavuru MS. Alveolar proteinosis syndrome: Pathogenesis, diagnosis, and management. Curr Opin Pulm Med. 2009;15:491–8.
5.
go back to reference Carre PC, Didier AP, Pipy BR, et al. The lavage fluid from a patient with alveolar proteinosis inhibits the in vitro chemiluminescence response and arachidonic acid metabolism of normal guinea pig alveolar macrophages. Am Rev Respir Dis. 1990;142:1068–72.PubMedCrossRef Carre PC, Didier AP, Pipy BR, et al. The lavage fluid from a patient with alveolar proteinosis inhibits the in vitro chemiluminescence response and arachidonic acid metabolism of normal guinea pig alveolar macrophages. Am Rev Respir Dis. 1990;142:1068–72.PubMedCrossRef
6.
go back to reference Gonzalez-Rothi RJ, Harris JO. Pulmonary alveolar proteinosis. Further evaluation of abnormal alveolar macrophages. Chest. 1986;90:656–61.PubMedCrossRef Gonzalez-Rothi RJ, Harris JO. Pulmonary alveolar proteinosis. Further evaluation of abnormal alveolar macrophages. Chest. 1986;90:656–61.PubMedCrossRef
7.
go back to reference Costello JF, Moriarty DC, Branthwaite MA, Turner-Warwick M, Corrin B. Diagnosis and management of alveolar proteinosis: The rôle of electron microscopy. Thorax. 1975;30:121–32. Costello JF, Moriarty DC, Branthwaite MA, Turner-Warwick M, Corrin B. Diagnosis and management of alveolar proteinosis: The rôle of electron microscopy. Thorax. 1975;30:121–32.
8.
go back to reference Patiroglu T, Akyildiz B, Patiroglu TE, Gulmez IY. Recurrent pulmonary alveolar proteinosis secondary to agammaglobulinemia. Pediatr Pulmonol. 2008;43:710–3.PubMedCrossRef Patiroglu T, Akyildiz B, Patiroglu TE, Gulmez IY. Recurrent pulmonary alveolar proteinosis secondary to agammaglobulinemia. Pediatr Pulmonol. 2008;43:710–3.PubMedCrossRef
9.
go back to reference Borie R, Danel C, Debray MP, et al. Pulmonary alveolar proteinosis. Eur Respir Rev. 2011;20:98–107.PubMedCrossRef Borie R, Danel C, Debray MP, et al. Pulmonary alveolar proteinosis. Eur Respir Rev. 2011;20:98–107.PubMedCrossRef
10.
go back to reference Stanley E, Lieschke GJ, Grail D, et al. Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci U S A. 1994;91:5592–6.PubMedCentralPubMedCrossRef Stanley E, Lieschke GJ, Grail D, et al. Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci U S A. 1994;91:5592–6.PubMedCentralPubMedCrossRef
Metadata
Title
Pulmonary Alveolar Proteinosis Secondary to Pneumocystis jiroveci Infection in an Infant with Common Variable Immunodeficiency
Authors
Dinesh Raj
Tsultem Doma Bhutia
Sandeep Mathur
Sushil Kumar Kabra
Rakesh Lodha
Publication date
01-09-2014
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 9/2014
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-013-1027-6

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