Top

Published in:

01-09-2014 | Clinical Brief

Autoimmune Hypothyroidism Presenting as Pituitary Hyperplasia

Authors: Rajendra Prasad Namburi, Takkolu Sriram Karthik, Amaresh Reddy Ponnala

Published in: Indian Journal of Pediatrics | Issue 9/2014

Abstract

Pituitary hyperplasia with hyperprolactinemia has been described as a rare presentation of primary hypothyroidism. A 12-y-old child presented with intermittent headache, easy fatigability, coarseness of facial features, and hoarseness of voice for 6 mo duration. Brain imaging findings showed pituitary hyperplasia; hormonal assessment revealed primary hypothyroidism and hyperprolactinemia. Pituitary hyperplasia regressed with thyroid hormone replacement therapy. This report describes an unusual case of pituitary hyperplasia with hyperprolactinemia secondary to primary hypothyroidism.

Nicholas WC, Russell WF. Primary hypothyroidism presenting as a pituitary mass. J Miss State Med Assoc. 2000;41:511–4.PubMed

Young M, Kattner K, Gupta K. Pituitary hyperplasia resulting from primary hypothyroidism mimicking macroadenomas. Br J Neurosurg. 1999;13:138–42.PubMedCrossRef

Amit A, Diwan SK. Pituitary hyperplasia resulting from primary hypothyroidism. Asian J Neurosurg. 2011;6:99–100.CrossRef

Koller KJ, Wolff RS, Warden MK, Zoeller RT. Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus. Proc Natl Acad Sci. 1987;84:7329–33.PubMedCentralPubMedCrossRef

Beck-Peccoz P, Brucker-Davis F, Persani L, Smallridge RC, Weintraub BD. Thyrotropin-secreting pituitary tumors. Endocr Rev. 1996;17:610–38.PubMed

Khawaja NM, Taher BM, Barham ME, Naser AA, Hadidy AM, Ahmad AT, et al. Pituitary enlargement in patients with primary hypothyroidism. Endocr Pract. 2006;12:29–34.PubMedCrossRef

Rajesh R, Ashish S, Deepak G. Reversible thyroid hyperplasia with hyperprolactinemia: A rare presenting manifestation of primary hypothyroidism. Indian J Endocrinol Metab. 2012;16:1037–9.CrossRef

Shimono T, Hatabu H, Kasagi K, Miki Y, Nishizawa S, Misaki T, et al. Rapid progression of pituitary hyperplasia in humans with primary hypothyroidism: Demonstration with MR imaging. Radiology. 1999;213:383–8.PubMedCrossRef

Chan AW, MacFarlane IA, Foy PM, Miles JB. Pituitary enlargement and hyperprolactinaemia due to primary hypothyroidism: Errors and delays in diagnosis. Br J Neurosurg. 1990;4:107–12.PubMedCrossRef

10.

Riedl S, Frisch H. Pituitary hyperplasia in a girl with gonadal dysgenesis and primary hypothyroidism. Horm Res. 1997;47:126–30.PubMedCrossRef

Title: Autoimmune Hypothyroidism Presenting as Pituitary Hyperplasia
Authors: Rajendra Prasad Namburi
Takkolu Sriram Karthik
Amaresh Reddy Ponnala
Publication date: 01-09-2014
Publisher: Springer India
Published in: Indian Journal of Pediatrics / Issue 9/2014
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI: https://doi.org/10.1007/s12098-013-1221-6

At a glance: The STEP trials

Springer Medicine

Autoimmune Hypothyroidism Presenting as Pituitary Hyperplasia

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 9/2014

Erratum to: Pediatric Postgraduate Training in India-Residents’ Perspective

Rational Management of Epilepsy

Body Temperature Changes of Newborns Under Fluorescent Versus LED Phototherapy: Correspondence

Wanderlust Ascaris- Migration Along Shunt Tract

5 α-Reductase Type 2 Deficiency — Response to Dihydrotestosterone Gel: Authors’ Reply

Pentapathology in Neurofibromatosis 1