Skip to main content
Top
Published in: Current Psychiatry Reports 9/2013

01-09-2013 | Complex Medical-Psychiatric Issues (MB Riba, Section Editor)

Psychopharmacology in Psycho-oncology

Authors: Rosangela Caruso, Luigi Grassi, Maria Giulia Nanni, Michelle Riba

Published in: Current Psychiatry Reports | Issue 9/2013

Login to get access

Abstract

Psychopharmacological intervention is a major clinical and research area in oncology and palliative care. Over the last 35 years, psychotropic drugs have been shown to have a number of important indications for the treatment of the most common psychiatric disorders, such as depression, anxiety, stress-related syndromes, severe adjustment disorders, sleep disorders and delirium, which combined affect at least 30-40% of patients with cancer and even a higher percentage of patients in an advanced phase of illness. The availability of new drugs, with less side-effects and safer pharmacological profiles, has been a major advance in clinical psycho-oncology. Interestingly, several drugs have also been found to be helpful for the adjuvant treatment of cancer-related symptoms, such as pain, hot flashes, pruritus, nausea and vomiting, fatigue, and cognitive impairment, making psychopharmacology an important tool for the improvement of cancer patients’ quality of life. The aim of this paper is to summarize recent relevant data concerning the use of psychotropic drugs, namely antidepressants, anxiolytics, antipsychotics, anticonvulsants and psychostimulants in patients with cancer.
Literature
1.
go back to reference Grassi L, Watson M, on behalf of the IPOS Federation of Psycho-Oncology Societies’ co-authors. Psychosocial care in cancer: an overview of psychosocial programmes and national cancer plans of countries within the International Federation of Psycho-Oncology Societies. Psychooncology. 2012;21:1027–33.PubMedCrossRef Grassi L, Watson M, on behalf of the IPOS Federation of Psycho-Oncology Societies’ co-authors. Psychosocial care in cancer: an overview of psychosocial programmes and national cancer plans of countries within the International Federation of Psycho-Oncology Societies. Psychooncology. 2012;21:1027–33.PubMedCrossRef
2.
go back to reference Holland J, Watson M, Dunn J. The IPOS New International Standard of Quality Cancer Care: integrating the psychosocial domain into routine care. Psychooncology. 2011;20:677–80.PubMedCrossRef Holland J, Watson M, Dunn J. The IPOS New International Standard of Quality Cancer Care: integrating the psychosocial domain into routine care. Psychooncology. 2011;20:677–80.PubMedCrossRef
3.
go back to reference Thekdi SM, Irarrazaval ME, Dunn L. Psychopharmacological interventions. In: Grassi L, Riba M, editors. Clinical Psycho-Oncology: an international perspective. Wiley: Chichester; 2012. p. 109–26.CrossRef Thekdi SM, Irarrazaval ME, Dunn L. Psychopharmacological interventions. In: Grassi L, Riba M, editors. Clinical Psycho-Oncology: an international perspective. Wiley: Chichester; 2012. p. 109–26.CrossRef
4.
go back to reference •• Mitchell AJ, Chan M, Bhatti H, Halton M, Grassi L, Johansen C, et al. Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. Lancet Oncol. 2011;12:160–74. This is a meta-analysis of the most significant studies in the field of oncology, hematology, and palliative care regarding the prevalence of psychiatric disorders among cancer patients.PubMedCrossRef •• Mitchell AJ, Chan M, Bhatti H, Halton M, Grassi L, Johansen C, et al. Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. Lancet Oncol. 2011;12:160–74. This is a meta-analysis of the most significant studies in the field of oncology, hematology, and palliative care regarding the prevalence of psychiatric disorders among cancer patients.PubMedCrossRef
5.
go back to reference • Singer S, Das-Munshi J, Brähler E. Prevalence of mental health conditions in cancer patients in acute care–a meta-analysis. Ann Oncol. 2010;21:925–30. This is a study evaluating the prevalence of psychiatric disorders in cancer inpatients in acute care.PubMedCrossRef • Singer S, Das-Munshi J, Brähler E. Prevalence of mental health conditions in cancer patients in acute care–a meta-analysis. Ann Oncol. 2010;21:925–30. This is a study evaluating the prevalence of psychiatric disorders in cancer inpatients in acute care.PubMedCrossRef
6.
go back to reference Brocken P, Prins JB, Dekhuijzen PN, van der Heijden HF. The faster the better?—A systematic review on distress in the diagnostic phase of suspected cancer, and the influence of rapid diagnostic pathways. Psychooncology. 2012;21:1–10.PubMed Brocken P, Prins JB, Dekhuijzen PN, van der Heijden HF. The faster the better?—A systematic review on distress in the diagnostic phase of suspected cancer, and the influence of rapid diagnostic pathways. Psychooncology. 2012;21:1–10.PubMed
7.
go back to reference Caraceni A, Grassi L. Delirium: acute confusional states in palliative medicine. 2nd ed. Oxford: Oxford University Press; 2011. Caraceni A, Grassi L. Delirium: acute confusional states in palliative medicine. 2nd ed. Oxford: Oxford University Press; 2011.
8.
go back to reference Derogatis LR, Feldstein M, Morrow G, et al. A survey of psychotropic drug prescriptions in an oncology population. Cancer. 1979;44:1919–29.PubMedCrossRef Derogatis LR, Feldstein M, Morrow G, et al. A survey of psychotropic drug prescriptions in an oncology population. Cancer. 1979;44:1919–29.PubMedCrossRef
9.
go back to reference Stiefel FC, Kornblith AB, Holland JC. Changes in prescription patterns of psychotropic drugs for cancer patients during a 10-year period. Cancer. 1990;65:1048–53.PubMedCrossRef Stiefel FC, Kornblith AB, Holland JC. Changes in prescription patterns of psychotropic drugs for cancer patients during a 10-year period. Cancer. 1990;65:1048–53.PubMedCrossRef
10.
go back to reference • Desplenter F, Bond C, Watson M, Burton C, Murchie P, Lee AJ, et al. Incidence and drug treatment of emotional distress after cancer diagnosis: a matched primary care case–control study. Br J Cancer. 2012;107:1644–51. The study quantified the higher incidence of new emotional distress in cancer patients in the first year post diagnosis and the use of psychotropic drugs.PubMedCrossRef • Desplenter F, Bond C, Watson M, Burton C, Murchie P, Lee AJ, et al. Incidence and drug treatment of emotional distress after cancer diagnosis: a matched primary care case–control study. Br J Cancer. 2012;107:1644–51. The study quantified the higher incidence of new emotional distress in cancer patients in the first year post diagnosis and the use of psychotropic drugs.PubMedCrossRef
11.
go back to reference De Bock GH, Musters RF, Bos HJ, Schröder CP, Mourits MJ, de Jong-van den Berg LT. Psychotropic medication during endocrine treatment for breast cancer. Support Care Cancer. 2012;20:1533–40.PubMedCrossRef De Bock GH, Musters RF, Bos HJ, Schröder CP, Mourits MJ, de Jong-van den Berg LT. Psychotropic medication during endocrine treatment for breast cancer. Support Care Cancer. 2012;20:1533–40.PubMedCrossRef
12.
go back to reference Ng CG, Boks MP, Smeets HM, Zainal NZ, de Wit NJ. Prescription patterns for psychotropic drugs in cancer patients; a large population study in the Netherlands. Psychooncology. 2013;22:762–7.PubMedCrossRef Ng CG, Boks MP, Smeets HM, Zainal NZ, de Wit NJ. Prescription patterns for psychotropic drugs in cancer patients; a large population study in the Netherlands. Psychooncology. 2013;22:762–7.PubMedCrossRef
13.
go back to reference Farriols C, Ferrández O, Planas J, et al. Changes in the prescription of psychotropic drugs in the palliative care of advanced cancer patients over a seven-year period. J Pain Symptom Manage. 2012;43:945–52.PubMedCrossRef Farriols C, Ferrández O, Planas J, et al. Changes in the prescription of psychotropic drugs in the palliative care of advanced cancer patients over a seven-year period. J Pain Symptom Manage. 2012;43:945–52.PubMedCrossRef
14.
go back to reference Ng CG, Boks MP, Zainal NZ, de Wit NJ. The prevalence and pharmacotherapy of depression in cancer patients. J Affect Disord. 2011;131:1–7.PubMedCrossRef Ng CG, Boks MP, Zainal NZ, de Wit NJ. The prevalence and pharmacotherapy of depression in cancer patients. J Affect Disord. 2011;131:1–7.PubMedCrossRef
15.
go back to reference Grassi L, Nanni MG, Uchitomi Y, Riba M. Pharmacotherapy of depression in people with cancer. In: Kissane DW, Maj M, Sartorius N, editors. Depression and cancer. Chichester: Wiley; 2011. p. 151–76. Grassi L, Nanni MG, Uchitomi Y, Riba M. Pharmacotherapy of depression in people with cancer. In: Kissane DW, Maj M, Sartorius N, editors. Depression and cancer. Chichester: Wiley; 2011. p. 151–76.
16.
go back to reference • Hart SL, Hoyt MA, Diefenbach M, et al. Meta-analysis of efficacy of interventions for elevated depressive symptoms in adults diagnosed with cancer. J Natl Cancer Inst. 2012;104:990–1004. This study suggests that psychological and pharmacologic approaches can be targeted productively toward cancer patients with elevated depressive symptoms.PubMedCrossRef • Hart SL, Hoyt MA, Diefenbach M, et al. Meta-analysis of efficacy of interventions for elevated depressive symptoms in adults diagnosed with cancer. J Natl Cancer Inst. 2012;104:990–1004. This study suggests that psychological and pharmacologic approaches can be targeted productively toward cancer patients with elevated depressive symptoms.PubMedCrossRef
17.
go back to reference • Laoutidis ZG. Mathiak K- Antidepressants in the treatment of depression/depressive symptoms in cancer patients: a systematic review and meta-analysis. BMC Psychiatry. 2013;13:140. doi:10.1186/1471-244X-13-140. This meta-analysis suggests that antidepressants can be effective in treating depressive symptoms besides clinical depression. • Laoutidis ZG. Mathiak K- Antidepressants in the treatment of depression/depressive symptoms in cancer patients: a systematic review and meta-analysis. BMC Psychiatry. 2013;13:140. doi:10.​1186/​1471-244X-13-140. This meta-analysis suggests that antidepressants can be effective in treating depressive symptoms besides clinical depression.
18.
go back to reference Rayner L, Price A, Hotopf M, Higginson IJ. The development of evidence-based European guidelines on the management of depression in palliative cancer care. Eur J Cancer. 2011;47:702–12.PubMedCrossRef Rayner L, Price A, Hotopf M, Higginson IJ. The development of evidence-based European guidelines on the management of depression in palliative cancer care. Eur J Cancer. 2011;47:702–12.PubMedCrossRef
20.
go back to reference Verdu B, Decosterd I, Buclin T, Stiefel F, Berney A. Antidepressants for the treatment of chronic pain. Drugs. 2008;68:2611–32.PubMedCrossRef Verdu B, Decosterd I, Buclin T, Stiefel F, Berney A. Antidepressants for the treatment of chronic pain. Drugs. 2008;68:2611–32.PubMedCrossRef
21.
go back to reference Bennett MI. Effectiveness of antiepileptic or antidepressant drugs when added to opioids for cancer pain: systematic review. Palliat Med. 2011;25:553–39.PubMedCrossRef Bennett MI. Effectiveness of antiepileptic or antidepressant drugs when added to opioids for cancer pain: systematic review. Palliat Med. 2011;25:553–39.PubMedCrossRef
22.
go back to reference Ripamonti C, Santini D, Maranzano E, Berti M, Roila F, on behalf of the ESMO Guidelines Working Group. Management of cancer pain: ESMO Clinical Practice Guidelines. Ann Oncology. 2012;23(Supplement 7):139–54. Ripamonti C, Santini D, Maranzano E, Berti M, Roila F, on behalf of the ESMO Guidelines Working Group. Management of cancer pain: ESMO Clinical Practice Guidelines. Ann Oncology. 2012;23(Supplement 7):139–54.
23.
go back to reference Smith EM, Pang H, Cirrincione C, et al. Alliance for Clinical Trials in Oncology. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. 2013;309:1359–67.PubMedCrossRef Smith EM, Pang H, Cirrincione C, et al. Alliance for Clinical Trials in Oncology. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. 2013;309:1359–67.PubMedCrossRef
24.
go back to reference Matsuoka H, Makimura C, Koyama A, Otsuka M, Okamoto W, et al. Pilot study of duloxetine for cancer patients with neuropathic pain non-responsive to pregabalin. Anticancer Res. 2012;32:1805–9.PubMed Matsuoka H, Makimura C, Koyama A, Otsuka M, Okamoto W, et al. Pilot study of duloxetine for cancer patients with neuropathic pain non-responsive to pregabalin. Anticancer Res. 2012;32:1805–9.PubMed
25.
go back to reference Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ. Amitriptyline for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2012. Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ. Amitriptyline for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2012.
26.
go back to reference Kast RE, Foley KF. Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects. Eur J Cancer Care (Engl). 2007;16:351–4.CrossRef Kast RE, Foley KF. Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects. Eur J Cancer Care (Engl). 2007;16:351–4.CrossRef
27.
go back to reference Riechelmann RP, Burman D, Tannock IF, Rodin G, Zimmermann C. Phase II trial of mirtazapine for cancer-related cachexia and anorexia. Am J Hosp Palliat Care. 2010;27:106–10.PubMedCrossRef Riechelmann RP, Burman D, Tannock IF, Rodin G, Zimmermann C. Phase II trial of mirtazapine for cancer-related cachexia and anorexia. Am J Hosp Palliat Care. 2010;27:106–10.PubMedCrossRef
28.
go back to reference Savard J, Morin CM. Insomnia in the context of cancer: a review of a neglected problem. J Clin Oncol. 2001;19:895–908.PubMed Savard J, Morin CM. Insomnia in the context of cancer: a review of a neglected problem. J Clin Oncol. 2001;19:895–908.PubMed
29.
go back to reference Palesh OG, Mustian KM, Peppone LJ, Janelsins M, et al. Impact of paroxetine on sleep problems in 426 cancer patients receiving chemotherapy: a trial from the University of Rochester Cancer Center Community Clinical Oncology Program. Sleep Med. 2012;13:1184–90.PubMedCrossRef Palesh OG, Mustian KM, Peppone LJ, Janelsins M, et al. Impact of paroxetine on sleep problems in 426 cancer patients receiving chemotherapy: a trial from the University of Rochester Cancer Center Community Clinical Oncology Program. Sleep Med. 2012;13:1184–90.PubMedCrossRef
30.
go back to reference Tanimukai H, Murai T, Okazaki N, Matsuda Y, et al. An observational study of insomnia and nightmare treated with trazodone in patients with advanced cancer. Am J Hosp Palliat Care. 2013;30:359–62.PubMedCrossRef Tanimukai H, Murai T, Okazaki N, Matsuda Y, et al. An observational study of insomnia and nightmare treated with trazodone in patients with advanced cancer. Am J Hosp Palliat Care. 2013;30:359–62.PubMedCrossRef
31.
go back to reference Morrow PK, Mattair DN, Hortobagyi GN. Hot flashes: a review of pathophysiology and treatment modalities. Oncologist. 2011;16:1658–64.PubMedCrossRef Morrow PK, Mattair DN, Hortobagyi GN. Hot flashes: a review of pathophysiology and treatment modalities. Oncologist. 2011;16:1658–64.PubMedCrossRef
32.
go back to reference Henry NL, Stearns V, Flockhart DA, Hayes DF, Riba M. Drug interactions and pharmacogenomics in the treatment of breast cancer and depression. Am J Psychiatry. 2008;165:1251–5.PubMedCrossRef Henry NL, Stearns V, Flockhart DA, Hayes DF, Riba M. Drug interactions and pharmacogenomics in the treatment of breast cancer and depression. Am J Psychiatry. 2008;165:1251–5.PubMedCrossRef
33.
go back to reference Desmarais JE, Looper KJ. Interactions between tamoxifen and antidepressants via cytochrome P450 2D6. J Clin Psychiatry. 2009;70:1688–97.PubMedCrossRef Desmarais JE, Looper KJ. Interactions between tamoxifen and antidepressants via cytochrome P450 2D6. J Clin Psychiatry. 2009;70:1688–97.PubMedCrossRef
34.
go back to reference • Caraci F, Crupi R, Drago F, Spina E. Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract. Curr Drug Metab. 2011;12:570–7. The article provides an updated review of clinically relevant metabolic drug interactions between selected anticancer drugs, SSRIs, and Hypericum extract, showing the inhibiting effect on one or more cytochrome P450 isoenzymes (CYPs), inducing effect on CYP3A4 and P-glycoprotein (P-gp), with reduction of plasma concentrations of anticancer durgs (e.g., imatinib, irinotecan and docetaxel).PubMed • Caraci F, Crupi R, Drago F, Spina E. Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract. Curr Drug Metab. 2011;12:570–7. The article provides an updated review of clinically relevant metabolic drug interactions between selected anticancer drugs, SSRIs, and Hypericum extract, showing the inhibiting effect on one or more cytochrome P450 isoenzymes (CYPs), inducing effect on CYP3A4 and P-glycoprotein (P-gp), with reduction of plasma concentrations of anticancer durgs (e.g., imatinib, irinotecan and docetaxel).PubMed
35.
go back to reference L’Espérance S, Frenette S, Dionne A, Dionne JY. Comité de l’évolution des pratiques en oncologie (CEPO) Pharmacological and non-hormonal treatment of hot flashes in breast cancer survivors: CEPO review and recommendations. Support Care Cancer. 2013;21:1461–74.PubMedCrossRef L’Espérance S, Frenette S, Dionne A, Dionne JY. Comité de l’évolution des pratiques en oncologie (CEPO) Pharmacological and non-hormonal treatment of hot flashes in breast cancer survivors: CEPO review and recommendations. Support Care Cancer. 2013;21:1461–74.PubMedCrossRef
36.
go back to reference Binkhorst L, Mathijssen RH, van Herk-Sukel MP et al. Unjustified prescribing of CYP2D6 inhibiting SSRIs in women treated with tamoxifen. Breast Cancer Res Treat. 2013. Binkhorst L, Mathijssen RH, van Herk-Sukel MP et al. Unjustified prescribing of CYP2D6 inhibiting SSRIs in women treated with tamoxifen. Breast Cancer Res Treat. 2013.
37.
go back to reference •• Breitbart W, Alici-Evcimen Y. Update on psychotropic medications for cancer-related fatigue. J Natl Compr Canc Netw. 2007;5:1081–91. The paper reviews the most important psychotropic drugs that have been studied for cancer-related fatigue, such as psychostimulants, wakefulness-promoting agents, and antidepressants. It also indicates that, studies are currently limited and that randomized, placebo-controlled trials with specific agents are needed. PubMed •• Breitbart W, Alici-Evcimen Y. Update on psychotropic medications for cancer-related fatigue. J Natl Compr Canc Netw. 2007;5:1081–91. The paper reviews the most important psychotropic drugs that have been studied for cancer-related fatigue, such as psychostimulants, wakefulness-promoting agents, and antidepressants. It also indicates that, studies are currently limited and that randomized, placebo-controlled trials with specific agents are needed. PubMed
38.
go back to reference Minton O, Richardson A, Sharpe M, Hotopf M, Stone P. A systematic review and meta-analysis of the pharmacological treatment of cancer-related fatigue. J Natl Cancer Inst. 2008;100:1155–66.PubMedCrossRef Minton O, Richardson A, Sharpe M, Hotopf M, Stone P. A systematic review and meta-analysis of the pharmacological treatment of cancer-related fatigue. J Natl Cancer Inst. 2008;100:1155–66.PubMedCrossRef
39.
go back to reference Dodd S, Malhi GS, Tiller J, et al. A consensus statement for safety monitoring guidelines of treatments for major depressive disorder. Austr New Zeal J Psychiatry. 2011;45:712–25.CrossRef Dodd S, Malhi GS, Tiller J, et al. A consensus statement for safety monitoring guidelines of treatments for major depressive disorder. Austr New Zeal J Psychiatry. 2011;45:712–25.CrossRef
40.
go back to reference Mazzocato C, Stiefel F, Buclin T, Berney A. Psychopharmacology in supportive care of cancer: a review for the clinician: II. Neuroleptics. Support Care Cancer. 2000;8:89–97.PubMedCrossRef Mazzocato C, Stiefel F, Buclin T, Berney A. Psychopharmacology in supportive care of cancer: a review for the clinician: II. Neuroleptics. Support Care Cancer. 2000;8:89–97.PubMedCrossRef
41.
go back to reference Candy B, Jackson KC, Jones L, Leurent B, Tookman A, King M. Drug therapy for delirium in terminally ill adult patients. Cochrane Database Syst Rev. 2012;11, CD004770.PubMed Candy B, Jackson KC, Jones L, Leurent B, Tookman A, King M. Drug therapy for delirium in terminally ill adult patients. Cochrane Database Syst Rev. 2012;11, CD004770.PubMed
42.
go back to reference •• Breitbart W, Alici Y. Evidence-based treatment of delirium in patients with cancer. J Clin Oncol. 2012;30:1206–14. This article presents evidence-based recommendations based on the results of pharmacologic and nonpharmacologic studies of the treatment and prevention of delirium.PubMedCrossRef •• Breitbart W, Alici Y. Evidence-based treatment of delirium in patients with cancer. J Clin Oncol. 2012;30:1206–14. This article presents evidence-based recommendations based on the results of pharmacologic and nonpharmacologic studies of the treatment and prevention of delirium.PubMedCrossRef
43.
go back to reference Kishi Y, Kato M, Okuyama T, Thurber S. Treatment of delirium with risperidone in cancer patients. Psychiatry Clin Neurosci. 2012;66:411–7.PubMedCrossRef Kishi Y, Kato M, Okuyama T, Thurber S. Treatment of delirium with risperidone in cancer patients. Psychiatry Clin Neurosci. 2012;66:411–7.PubMedCrossRef
44.
go back to reference Elsayem A, Bush SH, Munsell MF, Curry 3rd E, Calderon BB, Paraskevopoulos T, et al. Subcutaneous olanzapine for hyperactive or mixed delirium in patients with advanced cancer: a preliminary study. J Pain Symptom Manage. 2010;40:774–82.PubMedCrossRef Elsayem A, Bush SH, Munsell MF, Curry 3rd E, Calderon BB, Paraskevopoulos T, et al. Subcutaneous olanzapine for hyperactive or mixed delirium in patients with advanced cancer: a preliminary study. J Pain Symptom Manage. 2010;40:774–82.PubMedCrossRef
45.
go back to reference Hui D, Reddy A, Palla S, Bruera E. Neuroleptic prescription pattern for delirium in patients with advanced cancer. J Palliat Care. 2011;27:141–7.PubMed Hui D, Reddy A, Palla S, Bruera E. Neuroleptic prescription pattern for delirium in patients with advanced cancer. J Palliat Care. 2011;27:141–7.PubMed
46.
go back to reference Hui D, Bush SH, Gallo LE, Palmer JL, Yennurajalingam S, Bruera E. Neuroleptic dose in the management of delirium in patients with advanced cancer. J Pain Symptom Manage. 2010;39:186–96.PubMedCrossRef Hui D, Bush SH, Gallo LE, Palmer JL, Yennurajalingam S, Bruera E. Neuroleptic dose in the management of delirium in patients with advanced cancer. J Pain Symptom Manage. 2010;39:186–96.PubMedCrossRef
47.
go back to reference Pirri C, Bayliss E, Trotter J, Olver IN, Katris P, Drummond P, et al. Nausea still the poor relation in antiemetic therapy? The impact on cancer patients’ quality of life and psychological adjustment of nausea, vomiting and appetite loss, individually and concurrently as part of a symptom cluster. Support Care Cancer. 2013;21:735–48.PubMedCrossRef Pirri C, Bayliss E, Trotter J, Olver IN, Katris P, Drummond P, et al. Nausea still the poor relation in antiemetic therapy? The impact on cancer patients’ quality of life and psychological adjustment of nausea, vomiting and appetite loss, individually and concurrently as part of a symptom cluster. Support Care Cancer. 2013;21:735–48.PubMedCrossRef
48.
go back to reference McLean SL, Blenkinsopp A, Bennett MI. Using haloperidol as an antiemetic in palliative care: informing practice through evidence from cancer treatment and postoperative contexts. J Pain Palliat Care Pharmacother. 2013;27:132–5. McLean SL, Blenkinsopp A, Bennett MI. Using haloperidol as an antiemetic in palliative care: informing practice through evidence from cancer treatment and postoperative contexts. J Pain Palliat Care Pharmacother. 2013;27:132–5.
49.
go back to reference Ang SK, Shoemaker LK, Davis MP. Nausea and vomiting in advanced cancer. Am J Hosp Palliat Care. 2010;27:219–25.PubMedCrossRef Ang SK, Shoemaker LK, Davis MP. Nausea and vomiting in advanced cancer. Am J Hosp Palliat Care. 2010;27:219–25.PubMedCrossRef
50.
go back to reference Kaneishi K, Kawabata M, Morita T. Olanzapine for the relief of nausea in patients with advanced cancer and incomplete bowel obstruction. J Pain Symptom Manage. 2012;44:604–7.PubMedCrossRef Kaneishi K, Kawabata M, Morita T. Olanzapine for the relief of nausea in patients with advanced cancer and incomplete bowel obstruction. J Pain Symptom Manage. 2012;44:604–7.PubMedCrossRef
51.
go back to reference Thomson K, Henry B. Oncology clinical challenges: caring for patients with preexisting psychiatric illness. Clin J Oncol Nurs. 2012;16:471–80 Thomson K, Henry B. Oncology clinical challenges: caring for patients with preexisting psychiatric illness. Clin J Oncol Nurs. 2012;16:471–80
52.
go back to reference Baldwin KJ, Zivković SA, Lieberman FS. Neurologic emergencies in patients who have cancer: diagnosis and management. Neurol Clin. 2012;30:101–28.PubMedCrossRef Baldwin KJ, Zivković SA, Lieberman FS. Neurologic emergencies in patients who have cancer: diagnosis and management. Neurol Clin. 2012;30:101–28.PubMedCrossRef
53.
go back to reference Lorenz RA, Jackson CW, Saitz M. Adjunctive use of atypical antipsychotics for treatment-resistant generalized anxiety disorder. Pharmacotherapy. 2010;30:942–51.PubMedCrossRef Lorenz RA, Jackson CW, Saitz M. Adjunctive use of atypical antipsychotics for treatment-resistant generalized anxiety disorder. Pharmacotherapy. 2010;30:942–51.PubMedCrossRef
54.
go back to reference Patkar AA, Pae CU. Atypical antipsychotic augmentation strategies in the context of guideline-based care for the treatment of major depressive disorder. CNS Drugs. 2013;27 Suppl 1:29–37. Patkar AA, Pae CU. Atypical antipsychotic augmentation strategies in the context of guideline-based care for the treatment of major depressive disorder. CNS Drugs. 2013;27 Suppl 1:29–37.
56.
go back to reference Bodén R, Edman G, Reutfors J, Ostenson CG, Osby U. A comparison of cardiovascular risk factors for ten antipsychotic drugs in clinical practice. Neuropsychiatr Dis Treat. 2013;9:371–7.PubMedCrossRef Bodén R, Edman G, Reutfors J, Ostenson CG, Osby U. A comparison of cardiovascular risk factors for ten antipsychotic drugs in clinical practice. Neuropsychiatr Dis Treat. 2013;9:371–7.PubMedCrossRef
57.
go back to reference Lertxundi U, Hernandez R, Medrano J, Domingo-Echaburu S, García M. Aguirre C Antipsychotics and seizures: higher risk with atypicals? Seizure. 2013;22:141–3.PubMedCrossRef Lertxundi U, Hernandez R, Medrano J, Domingo-Echaburu S, García M. Aguirre C Antipsychotics and seizures: higher risk with atypicals? Seizure. 2013;22:141–3.PubMedCrossRef
58.
go back to reference Nooijen PM, Carvalho F, Flanagan RJ. Haematological toxicity of clozapine and some other drugs used in psychiatry. Hum Psychopharmacol. 2011;26:112–9.PubMedCrossRef Nooijen PM, Carvalho F, Flanagan RJ. Haematological toxicity of clozapine and some other drugs used in psychiatry. Hum Psychopharmacol. 2011;26:112–9.PubMedCrossRef
59.
go back to reference Murray M. Role of CYP pharmacogenetics and drug-drug interactions in the efficacy and safety of atypical and other antipsychotic agents. J Pharm Pharmacol. 2006;58(7):871–85.PubMedCrossRef Murray M. Role of CYP pharmacogenetics and drug-drug interactions in the efficacy and safety of atypical and other antipsychotic agents. J Pharm Pharmacol. 2006;58(7):871–85.PubMedCrossRef
60.
go back to reference Clevenger CV, Zheng J, Jablonski EM, Galbaugh TM, Fang F. From bench to bedside: future potential for the translation of prolactin inhibitors as breast cancer therapeutics. J Mammary Gland Biol Neoplasia. 2008;13:147–56.PubMedCrossRef Clevenger CV, Zheng J, Jablonski EM, Galbaugh TM, Fang F. From bench to bedside: future potential for the translation of prolactin inhibitors as breast cancer therapeutics. J Mammary Gland Biol Neoplasia. 2008;13:147–56.PubMedCrossRef
61.
go back to reference Stiefel F, Berney A, Mazzocato C. Psychopharmacology in supportive care in cancer: a review for the clinician. I. Benzodiazepines. Support Care Cancer. 1999;7:379–85.PubMedCrossRef Stiefel F, Berney A, Mazzocato C. Psychopharmacology in supportive care in cancer: a review for the clinician. I. Benzodiazepines. Support Care Cancer. 1999;7:379–85.PubMedCrossRef
62.
go back to reference Roscoe JA, Morrow GR, Aapro MS, Molassiotis A, Olver I. Anticipatory nausea and vomiting. Support Care Cancer. 2011;19:1533–8.PubMedCrossRef Roscoe JA, Morrow GR, Aapro MS, Molassiotis A, Olver I. Anticipatory nausea and vomiting. Support Care Cancer. 2011;19:1533–8.PubMedCrossRef
63.
go back to reference Testa A, Giannuzzi R, Sollazzo F, Petrongolo L, Bernardini L. Dain SPsychiatric emergencies (part II): psychiatric disorders coexisting with organic diseases. Eur Rev Med Pharmacol Sci. 2013;17 Suppl 1:65–85.PubMed Testa A, Giannuzzi R, Sollazzo F, Petrongolo L, Bernardini L. Dain SPsychiatric emergencies (part II): psychiatric disorders coexisting with organic diseases. Eur Rev Med Pharmacol Sci. 2013;17 Suppl 1:65–85.PubMed
64.
go back to reference Skrobik Y, Leger C, Cossette M, Michaud V, Turgeon J. Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. Crit Care Med. 2013;41:999–1008.PubMedCrossRef Skrobik Y, Leger C, Cossette M, Michaud V, Turgeon J. Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. Crit Care Med. 2013;41:999–1008.PubMedCrossRef
65.
go back to reference Costantini C, Ale-Ali A. Helsten T Sleep aid prescribing practices during neoadjuvant or adjuvant chemotherapy for breast cancer. J Palliat Med. 2011;14:563–6.PubMedCrossRef Costantini C, Ale-Ali A. Helsten T Sleep aid prescribing practices during neoadjuvant or adjuvant chemotherapy for breast cancer. J Palliat Med. 2011;14:563–6.PubMedCrossRef
66.
go back to reference Joffe H, Partridge A, Giobbie-Hurder A, Li X, Habin K, Goss P, et al. Augmentation of venlafaxine and selective serotonin reuptake inhibitors with zolpidem improves sleep and quality of life in breast cancer patients with hot flashes: a randomized, double-blind, placebo-controlled trial. Menopause. 2010;17:908–16.PubMedCrossRef Joffe H, Partridge A, Giobbie-Hurder A, Li X, Habin K, Goss P, et al. Augmentation of venlafaxine and selective serotonin reuptake inhibitors with zolpidem improves sleep and quality of life in breast cancer patients with hot flashes: a randomized, double-blind, placebo-controlled trial. Menopause. 2010;17:908–16.PubMedCrossRef
67.
go back to reference Hirst A, Sloan R. Benzodiazepines and related drugs for insomnia in palliative care. Cochrane Database Syst Rev. 2002;4, CD003346.PubMed Hirst A, Sloan R. Benzodiazepines and related drugs for insomnia in palliative care. Cochrane Database Syst Rev. 2002;4, CD003346.PubMed
68.
go back to reference McKnight RF, Adida M, Budge K, Stockton S, Goodwin GM, Geddes JR. Lithium toxicity profile: a systematic review and meta-analysis. Lancet. 2012;379:721–8.PubMedCrossRef McKnight RF, Adida M, Budge K, Stockton S, Goodwin GM, Geddes JR. Lithium toxicity profile: a systematic review and meta-analysis. Lancet. 2012;379:721–8.PubMedCrossRef
69.
go back to reference • Fallon MT. Neuropathic pain in cancer. Br J Anaesth. 2013;111:105–11. This review summarizes standard guidelines for the use of anticonvulsants (e.g. pregabalin and gabapentin), antidepressants (e.g. duloxetine and tricyclics), and topical treatments (e.g. capsaicin and lidocaine) in cancer pain, although the authors complain a lack of good-quality clinical trials in cancer-related neuropathic pain.PubMedCrossRef • Fallon MT. Neuropathic pain in cancer. Br J Anaesth. 2013;111:105–11. This review summarizes standard guidelines for the use of anticonvulsants (e.g. pregabalin and gabapentin), antidepressants (e.g. duloxetine and tricyclics), and topical treatments (e.g. capsaicin and lidocaine) in cancer pain, although the authors complain a lack of good-quality clinical trials in cancer-related neuropathic pain.PubMedCrossRef
70.
go back to reference Pruitt AA. Medical management of patients with brain tumors. Curr Treat Options Neurol. 2011;13:413–26.PubMedCrossRef Pruitt AA. Medical management of patients with brain tumors. Curr Treat Options Neurol. 2011;13:413–26.PubMedCrossRef
72.
go back to reference Maschio M, Dinapoli L, Mingoia M, Sperati F, et al. Lacosamide as add-on in brain tumor-related epilepsy: preliminary report on efficacy and tolerability. J Neurol. 2011;258:2100–4.PubMedCrossRef Maschio M, Dinapoli L, Mingoia M, Sperati F, et al. Lacosamide as add-on in brain tumor-related epilepsy: preliminary report on efficacy and tolerability. J Neurol. 2011;258:2100–4.PubMedCrossRef
73.
go back to reference Masand PS, Tesar GE. Use of stimulants in the medically ill. Psychiatr Clin North Am. 1996;19:515–47.PubMedCrossRef Masand PS, Tesar GE. Use of stimulants in the medically ill. Psychiatr Clin North Am. 1996;19:515–47.PubMedCrossRef
74.
go back to reference Homsi J, Walsh D, Nelson KA. Psychostimulants in supportive care. Support Care Cancer. 2000;8:385–97.PubMedCrossRef Homsi J, Walsh D, Nelson KA. Psychostimulants in supportive care. Support Care Cancer. 2000;8:385–97.PubMedCrossRef
75.
go back to reference • Portela MA, Rubiales AS, Centeno C. The use of psychostimulants in cancer patients. Curr Opin Support Palliat Care. 2011;5:164–8. This article reviews the most recent studies that examine the efficacy of psychostimulants for the relief of symptoms such as asthenia and depression in cancer patients.PubMedCrossRef • Portela MA, Rubiales AS, Centeno C. The use of psychostimulants in cancer patients. Curr Opin Support Palliat Care. 2011;5:164–8. This article reviews the most recent studies that examine the efficacy of psychostimulants for the relief of symptoms such as asthenia and depression in cancer patients.PubMedCrossRef
76.
go back to reference • Minton O, Richardson A, Sharpe M, Hotopf M, Stone PC. Psychostimulants for the management of cancer-related fatigue: a systematic review and meta-analysis. J Pain Symptom Manage. 2011;41:761–7. This article summarizes the increasing evidence for the use of psychostimulants, particularly methylphenidate, in the treatment of cancer-related fatigue.PubMedCrossRef • Minton O, Richardson A, Sharpe M, Hotopf M, Stone PC. Psychostimulants for the management of cancer-related fatigue: a systematic review and meta-analysis. J Pain Symptom Manage. 2011;41:761–7. This article summarizes the increasing evidence for the use of psychostimulants, particularly methylphenidate, in the treatment of cancer-related fatigue.PubMedCrossRef
77.
go back to reference • Breitbart W, Alici Y. Psychostimulants for cancer-related fatigue. J Natl Compr Canc Netw. 2010;8:933–42. This article presents a comprehensive review of the use of psychostimulant agents for fatigue among patients with cancer, including an overview of the clinical trials with psychostimulants and of the clinical guidelines available for treatment of cancer-related fatigue. • Breitbart W, Alici Y. Psychostimulants for cancer-related fatigue. J Natl Compr Canc Netw. 2010;8:933–42. This article presents a comprehensive review of the use of psychostimulant agents for fatigue among patients with cancer, including an overview of the clinical trials with psychostimulants and of the clinical guidelines available for treatment of cancer-related fatigue.
78.
go back to reference Von Ah D, Jansen C, Allen DH, Schiavone RM, Wulff J. Putting evidence into practice: evidence-based interventions for cancer and cancer treatment-related cognitive impairment. Clin J Oncol Nurs. 2011;15:607–15.CrossRef Von Ah D, Jansen C, Allen DH, Schiavone RM, Wulff J. Putting evidence into practice: evidence-based interventions for cancer and cancer treatment-related cognitive impairment. Clin J Oncol Nurs. 2011;15:607–15.CrossRef
79.
go back to reference Gehring K, Roukema JA, Sitskoorn MM. Review of recent studies on interventions for cognitive deficits in patients with cancer. Expert Rev Anticancer Ther. 2012;12:255–69.PubMedCrossRef Gehring K, Roukema JA, Sitskoorn MM. Review of recent studies on interventions for cognitive deficits in patients with cancer. Expert Rev Anticancer Ther. 2012;12:255–69.PubMedCrossRef
80.
go back to reference Zafra-Ceres M, de Haro T, Farez-Vidal E, Blancas I, Bandres F, de Dueñas EM, et al. Influence of CYP2D6 Polymorphisms on Serum Levels of Tamoxifen Metabolites in Spanish Women with Breast Cancer. Int J Med Sci. 2013;10:932–7.PubMedCrossRef Zafra-Ceres M, de Haro T, Farez-Vidal E, Blancas I, Bandres F, de Dueñas EM, et al. Influence of CYP2D6 Polymorphisms on Serum Levels of Tamoxifen Metabolites in Spanish Women with Breast Cancer. Int J Med Sci. 2013;10:932–7.PubMedCrossRef
81.
go back to reference Garland SN, Valentine D, Desai K, Li S, Langer C, Evans T, Mao JJ. Complementary and Alternative Medicine (CAM) use and benefit finding among cancer patients. J Altern Complement Med. 2013. doi:10.1089/acm.2012.0964. Garland SN, Valentine D, Desai K, Li S, Langer C, Evans T, Mao JJ. Complementary and Alternative Medicine (CAM) use and benefit finding among cancer patients. J Altern Complement Med. 2013. doi:10.​1089/​acm.​2012.​0964.
Metadata
Title
Psychopharmacology in Psycho-oncology
Authors
Rosangela Caruso
Luigi Grassi
Maria Giulia Nanni
Michelle Riba
Publication date
01-09-2013
Publisher
Springer US
Published in
Current Psychiatry Reports / Issue 9/2013
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-013-0393-0

Other articles of this Issue 9/2013

Current Psychiatry Reports 9/2013 Go to the issue

Sleep Disorders (RM Benca, Section Editor)

The Link Between Suicide and Insomnia: Theoretical Mechanisms

Mood Disorders (SM Strakowski, Section Editor)

Is Depression Simply a Nonspecific Response to Brain Injury?

Geriatric Disorders (H Lavretsky, Section Editor)

Depression in Cognitive Impairment

Complex Medical-Psychiatric Issues (MB Riba, Section Editor)

The Comorbidity between Depression and Diabetes