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Published in: European Archives of Oto-Rhino-Laryngology 4/2016

01-04-2016 | Rhinology

Psychological stress and its relationship with persistent allergic rhinitis

Authors: Diaa El Din Mohamed El Hennawi, Mohamed Rifaat Ahmed, Alaa Mohamed Farid

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2016

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Abstract

Allergic rhinitis is considered to be a major health problem that impairs quality of life. A possible relationship with psychological stress may exist. The aim of this study is to verify the relationship between persistent allergic rhinitis (PAR) and psychological stress aiming to improve treatment and thereby quality of life (QOL) of patients. Patients with PAR (166) were diagnosed then analyzed using the Kessler Psychological Distress Scale. Patients with allergic rhinitis and who were positive on the Kessler scale (122) were randomly divided equally into a control group which received levocetirizine and a study group which received levocetirizine and imipramine. Nasal symptom assessment and QOL assessment were performed in all patients after treatment. Of the 166 patients with PAR, 122 (73.5 %) were positive on the Kessler Psychological Distress Scale. There was a marked improvement in the study group compared with the control group as regards nasal symptoms with better QOL in the study group (6.93) compared with the control group (2.13). Psychological stress has a strong impact on persistent allergic rhinitis. When stress is controlled by a combined treatment of imipramine and levocetirizine, allergic rhinitis symptoms improved and a better QOL was obtained.
Level of evidence: 3b.
Literature
1.
2.
go back to reference Bourdin A, Gras D, Vachier I, Chanez P (2009) Upper airway 1: allergic rhinitis and asthma: united disease through epithelial cells. Thorax 64:999–1004CrossRefPubMed Bourdin A, Gras D, Vachier I, Chanez P (2009) Upper airway 1: allergic rhinitis and asthma: united disease through epithelial cells. Thorax 64:999–1004CrossRefPubMed
3.
go back to reference Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A et al (2008) Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 63:8–160CrossRefPubMed Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A et al (2008) Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 63:8–160CrossRefPubMed
4.
go back to reference Sansone RA, Sansone LA (2011) Allergic rhinitis: relationships with anxiety and mood syndromes. Innov Clin Neurosci 8:12–17 Sansone RA, Sansone LA (2011) Allergic rhinitis: relationships with anxiety and mood syndromes. Innov Clin Neurosci 8:12–17
5.
go back to reference Cuffel B, Wamboldt M, Borish L, Kennedy S, Crystal-Peters J (1999) Economic consequences of comorbid depression, anxiety, and allergic rhinitis. Psychosomatics 40:491–496CrossRefPubMed Cuffel B, Wamboldt M, Borish L, Kennedy S, Crystal-Peters J (1999) Economic consequences of comorbid depression, anxiety, and allergic rhinitis. Psychosomatics 40:491–496CrossRefPubMed
6.
go back to reference Patten SB, Williams JVA (2007) Self-reported allergies and their relationship to several Axis I disorders in a community sample. Int J Psychiatry Med 37:11–22CrossRefPubMed Patten SB, Williams JVA (2007) Self-reported allergies and their relationship to several Axis I disorders in a community sample. Int J Psychiatry Med 37:11–22CrossRefPubMed
7.
go back to reference Postolache TT, Komarow HD, Stiller JW, Tonelli LH (2005) Allergy, depression, and suicide. Dir Psychiatry 25:59–70 Postolache TT, Komarow HD, Stiller JW, Tonelli LH (2005) Allergy, depression, and suicide. Dir Psychiatry 25:59–70
8.
go back to reference Dunn AJ, Swiergiel AH, de Beaurepaire R (2005) Cytokines as mediators of depression: what can we learn from animal studies? Neurosci Biobehav Rev 29:891–909CrossRefPubMed Dunn AJ, Swiergiel AH, de Beaurepaire R (2005) Cytokines as mediators of depression: what can we learn from animal studies? Neurosci Biobehav Rev 29:891–909CrossRefPubMed
9.
go back to reference Fang BJ, Tonelli LH, Soriano J, Postolache TT (2010) Disturbed sleep: linking allergic rhinitis, mood and suicidal behavior. Front Biosci 2:30–46CrossRef Fang BJ, Tonelli LH, Soriano J, Postolache TT (2010) Disturbed sleep: linking allergic rhinitis, mood and suicidal behavior. Front Biosci 2:30–46CrossRef
10.
go back to reference Léger D, Annesi-Maesano I, Carat F, Rugina M, Chanal I, Pribil C et al (2006) Allergic rhinitis and its consequences on quality of sleep: an unexplored area. Arch Intern Med 166:1744–1748CrossRefPubMed Léger D, Annesi-Maesano I, Carat F, Rugina M, Chanal I, Pribil C et al (2006) Allergic rhinitis and its consequences on quality of sleep: an unexplored area. Arch Intern Med 166:1744–1748CrossRefPubMed
11.
go back to reference Kremer B, den Hartog HM, Jolles J (2002) Relationship between allergic rhinitis, disturbed cognitive functions and psychological well-being. Clin Exp Allergy 32:1310–1315CrossRefPubMed Kremer B, den Hartog HM, Jolles J (2002) Relationship between allergic rhinitis, disturbed cognitive functions and psychological well-being. Clin Exp Allergy 32:1310–1315CrossRefPubMed
12.
go back to reference Wilken JA, Berkowitz R, Kane R (2002) Decrements in vigilance and cognitive functioning associated with ragweed-induced allergic rhinitis. Ann Allergy Asthma Immunol 89:372–380CrossRefPubMed Wilken JA, Berkowitz R, Kane R (2002) Decrements in vigilance and cognitive functioning associated with ragweed-induced allergic rhinitis. Ann Allergy Asthma Immunol 89:372–380CrossRefPubMed
13.
go back to reference Wamboldt MZ, Hewitt JK, Schmitz S, Wamboldt FS, Räsänen M, Koskenvuo M et al (2000) Familiar association between allergic disorders and depression in adult Finnish twins. Am J Med Genet 96:146–153CrossRefPubMed Wamboldt MZ, Hewitt JK, Schmitz S, Wamboldt FS, Räsänen M, Koskenvuo M et al (2000) Familiar association between allergic disorders and depression in adult Finnish twins. Am J Med Genet 96:146–153CrossRefPubMed
14.
go back to reference Mullol J, Bachert C, Bousquet J (2005) Management of persistent allergic rhinitis: evidence-based treatment with levocetirizine. Ther Clin Risk Manag 1:265–271PubMedPubMedCentral Mullol J, Bachert C, Bousquet J (2005) Management of persistent allergic rhinitis: evidence-based treatment with levocetirizine. Ther Clin Risk Manag 1:265–271PubMedPubMedCentral
15.
go back to reference Rao KS, Menon PK, Hilman BC, Sebastian CS, Bairnsfather L (1988) Duration of the suppressive effect of tricyclic antidepressants on histamine-induced wheal-and-flare reactions in human skin. J Allergy Clin Immunol 82:752–757CrossRefPubMed Rao KS, Menon PK, Hilman BC, Sebastian CS, Bairnsfather L (1988) Duration of the suppressive effect of tricyclic antidepressants on histamine-induced wheal-and-flare reactions in human skin. J Allergy Clin Immunol 82:752–757CrossRefPubMed
16.
go back to reference Zhang Y, Zhen H, Yao W, Bian F, Mao X, Yang X, Jin S (2013) Antidepressant drug, desipramine, alleviates allergic rhinitis by regulating Treg and Th17 cells. Int J Immunopathol Pharmacol 26:107–115PubMed Zhang Y, Zhen H, Yao W, Bian F, Mao X, Yang X, Jin S (2013) Antidepressant drug, desipramine, alleviates allergic rhinitis by regulating Treg and Th17 cells. Int J Immunopathol Pharmacol 26:107–115PubMed
18.
go back to reference Anderson TM, Sunderland M, Andrews G, Titov N, Dear BF, Sachdev PS (2013) The 10-item Kessler psychological distress scale (K10) as a screening instrument in older individuals. Am J Geriatr Psychiatry 21:596–606CrossRefPubMed Anderson TM, Sunderland M, Andrews G, Titov N, Dear BF, Sachdev PS (2013) The 10-item Kessler psychological distress scale (K10) as a screening instrument in older individuals. Am J Geriatr Psychiatry 21:596–606CrossRefPubMed
20.
go back to reference Woods L, Craig TJ (2006) The importance of rhinitis on sleep, daytime somnolence, productivity and fatigue. Curr Opin Pulm Med 12:390–396PubMed Woods L, Craig TJ (2006) The importance of rhinitis on sleep, daytime somnolence, productivity and fatigue. Curr Opin Pulm Med 12:390–396PubMed
21.
go back to reference Canonica GW, Bousquet J, Van Hammee G, Bachert C, Durham SR, Klimek L, XPERT Study Group et al (2006) Levocetirizine improves health-related quality of life and health status in persistent allergic rhinitis. Respir Med 100:1706–1715CrossRef Canonica GW, Bousquet J, Van Hammee G, Bachert C, Durham SR, Klimek L, XPERT Study Group et al (2006) Levocetirizine improves health-related quality of life and health status in persistent allergic rhinitis. Respir Med 100:1706–1715CrossRef
22.
go back to reference Postolache TT, Lapidus M, Sander ER, Langenberg P, Hamilton RG, Soriano JJ et al (2007) Changes in allergy symptoms and depression scores are positively correlated in patients with recurrent mood disorders exposed to seasonal peaks in aeroallergens. Sci World J 7:1968–1977CrossRef Postolache TT, Lapidus M, Sander ER, Langenberg P, Hamilton RG, Soriano JJ et al (2007) Changes in allergy symptoms and depression scores are positively correlated in patients with recurrent mood disorders exposed to seasonal peaks in aeroallergens. Sci World J 7:1968–1977CrossRef
23.
go back to reference Wright J, Cohen S (2005) The impact of stress on the development and expression of atopy. Curr Opin Allergy Clin Immunol 5:23–29CrossRefPubMed Wright J, Cohen S (2005) The impact of stress on the development and expression of atopy. Curr Opin Allergy Clin Immunol 5:23–29CrossRefPubMed
24.
go back to reference Marshall G, Roy S (2007) Stress and allergic disease. In: Ader R (ed) Psychoneuroimmunology. Academic Press, Amsterdam, pp 799–824CrossRef Marshall G, Roy S (2007) Stress and allergic disease. In: Ader R (ed) Psychoneuroimmunology. Academic Press, Amsterdam, pp 799–824CrossRef
25.
go back to reference Krouse HJ, Davis JE, Krouse JH (2002) Immune mediators in allergic rhinitis and sleep. Otolaryngol Head Neck Surg 126:607–613CrossRefPubMed Krouse HJ, Davis JE, Krouse JH (2002) Immune mediators in allergic rhinitis and sleep. Otolaryngol Head Neck Surg 126:607–613CrossRefPubMed
26.
go back to reference Schoenwetter WF, Dupclay L Jr, Appajosyula S, Botteman MF, Pashos CL (2004) Economic impact and quality-of-life burden of allergic rhinitis. Curr Med Res Opin 20:305–317CrossRefPubMed Schoenwetter WF, Dupclay L Jr, Appajosyula S, Botteman MF, Pashos CL (2004) Economic impact and quality-of-life burden of allergic rhinitis. Curr Med Res Opin 20:305–317CrossRefPubMed
Metadata
Title
Psychological stress and its relationship with persistent allergic rhinitis
Authors
Diaa El Din Mohamed El Hennawi
Mohamed Rifaat Ahmed
Alaa Mohamed Farid
Publication date
01-04-2016
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 4/2016
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-015-3641-6

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