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01-04-2019 | Protozoa | Brief Communication

Trichostatin A (TSA) levels in response to treatment of rainbow trout with gamma-irradiated trophonts against Ichthyophthirius multifiliis

Authors: Saeed Moodi, Sakineh Yeganeh, Marzieh Heidarieh, Omid Safari

Published in: Comparative Clinical Pathology | Issue 2/2019

Abstract

Ichthyophthirius multifiliis is a large ciliated protozoan parasite that is widely distributed in freshwater fish. Histone deacetylase inhibitors (HDACi), e.g., trichostatin A (TSA), are recognized as new agents for the treatment of a wide range of parasitic diseases. In this study, TSA levels induced by gamma-irradiated trophonts and alginate/calcium phosphate nanoparticles were measured after 30 days following treatment against I. multifiliis in spleen, kidney, and liver tissues of rainbow trout. This sounds like TSA is an anti-parasitic enzyme that can increase in spleen, kidney, and liver tissues following treatment of rainbow trout against I. multifiliis (P < 0.05). Moreover, the results obtained from this study showed that the TSA activity level is tissue-dependent. The highest significance levels for TSA activity were found in spleen tissue of treated and healthy groups compared with the levels of the both liver and kidney tissues (P < 0.05).

Andrews KT, Haque A, Jones MK (2012) HDAC inhibitors in parasitic diseases. Immunol J Cell Biol 90(1):66–77. https://doi.org/10.1038/icb.2011.97 CrossRef

Bougdour A, Maubon D, Baldacci P, Ortet P, Bastien O, Bouillon A, Barale JC, Pelloux H, Menard R, Hakimi MA (2009) Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites. J Exp Med 206(4):953–966. https://doi.org/10.1084/jem.20082826 CrossRefPubMedPubMedCentral

Carrillo AK, Guiguemde WA, Guy RK (2015) Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). Bioorg Med Chem 23:5151–5155. https://doi.org/10.1016/j.bmc.2014.12.066 CrossRefPubMed

Engel JA, Jones AJ, Avery VM, Sumanadasa SDM, Ng SS, Fairlie DP, Adams TS, Andrews KT (2015) Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites. Int J Parasitol Drugs Drug Resist 5:117–126. https://doi.org/10.1016/j.ijpddr.2015.05.004 CrossRefPubMedPubMedCentral

Heidarieh M, Daryalal F, Mirvaghefi AR, Shahbazfar AA, Moodi S, Heidarieh H (2014a) J Appl Ichthyol 30(3):543–545. https://doi.org/10.1111/jai.12417 CrossRef

Heidarieh M, Hedayati rad M, Mirvaghef AR, Diallo A, Mousavi S, Sheikhzadeh N, Shahbazfar AA (2014b) Effect of gamma-irradiation on inactivation of Ichthyophthirius multifiliis trophonts and its efficacy on host response in experimentally immunized rainbow trout (Oncorhynchus mykiss). Turk J Vet Anim Sci 38(4):388–393. https://doi.org/10.3906/vet-1312-78 CrossRef

Heidarieh M, Diallo A, Moodi S, Taghinejad V, Akbari M, Monfaredan A (2015) Gene expression analysis in rainbow trout (Oncorhynchus mykiss) skin: immunological responses to radiovaccine against Ichthyophthirius multifiliis. Rev Med Vet 66:233–242. https://doi.org/10.13140/RG.2.1.4019.8889 CrossRef

Heimburg T, Chakrabarti A, Lancelot J, Marek M, Melesina J, Hauser AT, Shaik TB, Duclaud S, Robaa D, Erdmann F (2016) Structure-based design and synthesis of novel inhibitors targeting HDAC8 from Schistosoma mansoni for the treatment of schistosomiasis. J Med Chem 59:2423–2435. https://doi.org/10.1021/acs.jmedchem.5b01478 CrossRefPubMed

Loidl P (1988) Towards an understanding of the biological function of histone acetylation. FEBS Lett 227:91–95. https://doi.org/10.1016/0014-5793(88)80874-3 CrossRefPubMed

Mohamed HA, Khuphe M, Boardman SJ, Shepherd S, Phillips RM, Thornton PD, Willans CE (2018) Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes. RSC Adv 8:10474–10477. https://doi.org/10.1039/C8RA00450A CrossRef

Murray PJ, Kranz M, Ladlow M, Taylor S, Berst F, Holmes AB, Keavey KN, Jaxa-Chamiec A, Seale PW, Stead P, Upton RJ, Croft SL, Clegg W, Elsegood MR (2001) The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin. Bioorg Med Chem Lett 11(6):773–776. https://doi.org/10.1016/S0960-894X(01)00049-X CrossRefPubMed

Owen GI, Richer JK, Tung L, Takimoto G, Horwitz KB (1998) Progesterone regulates transcription of the p21 (WAF1) cyclin-dependent kinase inhibitor gene through Sp1 and CBP/p300. J Biol Chem 73:10696–10701. https://doi.org/10.1074/jbc.273.17.10696 CrossRef

Sereno D, Alegre AM, Silvestre R, Vergnes B, Ouaissi A (2005) In vitro anti-leishmanial activity of nicotinamide. Antimicrob Agents Chemother 49(2):808–812. https://doi.org/10.1016/j.parint.2010.09.005 CrossRefPubMedPubMedCentral

Sheikhzadeh N, Heidarieh M, Falsafi M, Nofouzi K, Tukmechi A (2017) Effects of gamma-irradiated Ichthyophthirius multifiliis coated with calcium phosphate nanoparticles on immunological responses in rainbow trout (Oncorhynchus mykiss) skin mucus. Iran Vet J 13(2):38–47 (In Persian)

Soares MB, Silva CV, Bastos TM, Guimaraes ET, Figueira CP, Smirlis D, Azevedo JWF (2012) Anti-Trypanosoma cruzi activity of nicotinamide. Acta Trop 122(2):224–229. https://doi.org/10.1016/j.actatropica.2012.01.001 CrossRefPubMed

Sonda S, Morf L, Bottova I, Baetschmann H, Rehrauer H, Caflisch A, Hakimi MA, Hehl AB (2010) Epigenetic mechanisms regulate stage differentiation in the minimized protozoan Giardia lamblia. Mol Microbiol 76(1):48–67. https://doi.org/10.1111/j.1365-2958.2010.07062.x CrossRefPubMed

Tsuji N, Kobayashi M, Nagashima K, Wakisaka Y, Koizumi K (1976) A new antifungal antibiotic, trichostatin. J Antibiot 29(1):1–6. https://doi.org/10.7164/antibiotics.29.1 CrossRefPubMed

Tucker CS, Robinson EH (1990) Channel catfish farming handbook. Van Nostrand Reinhold, New YorkCrossRef

Vanniasinkam T, Ertl H, Tang Q (2006) Trichostatin-A enhances adaptive immune responses to DNA vaccination. J Clin Virol 36(4):292–297. https://doi.org/10.1016/j.jcv.2006.04.009 CrossRefPubMed

Veiga-Santos P, Reignault LC, Huber K, Bracher FDE, Souza WDE, Carvalho TM (2014) Inhibition of NADþ-dependent histone deacetylases (sirtuins) causes growth arrest and activates both apoptosis and autophagy in the pathogenic protozoan Trypanosoma cruzi. Parasitology 141:814–825. https://doi.org/10.1017/S0031182013001704 CrossRefPubMed

Vigushin DM, Ali S, Pace PE, Mirsaidi N, Ito K, Adcock I, Coombes RC (2001) Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in Vivo. Clin Cancer Res 7(4):971–976PubMed

Wang Q, Rosa BA, Nare B, Powell K, Valente S, Rotili D, Mai A, Marshall GR, Mitreva M (2015) Targeting lysine deacetylases (KDACs) in parasites. PLoS Negl Trop Dis 9(9):e0004026. https://doi.org/10.1371/journal.pntd.0004026 CrossRefPubMedPubMedCentral

Title: Trichostatin A (TSA) levels in response to treatment of rainbow trout with gamma-irradiated trophonts against Ichthyophthirius multifiliis
Authors: Saeed Moodi
Sakineh Yeganeh
Marzieh Heidarieh
Omid Safari
Publication date: 01-04-2019
Publisher: Springer London
Keyword: Protozoa
Published in: Comparative Clinical Pathology / Issue 2/2019
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-019-02903-4

At a glance: The STEP trials

Springer Medicine

Trichostatin A (TSA) levels in response to treatment of rainbow trout with gamma-irradiated trophonts against Ichthyophthirius multifiliis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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