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01-04-2019 | Type 2 Diabetes | Original Article

Diabetes upregulates the expression of HSP90 and downregulates HSP70 in the liver of diabetic rats

Authors: Kawther Faisal Amawi, Inas Saleh Al-Mazari, Ali Alsarhan, Hamza Qasim Mohammad Alhamad, Ahed J. Alkhatib

Published in: Comparative Clinical Pathology | Issue 2/2019

Abstract

Type 2 diabetes (T2D) is a health problem with global impact. T2D affects various systems in the body, and there is a need to discover new therapeutic lines to cope with emerging therapeutic needs because the current therapeutic options are limited. The objectives of the present study were to investigate the expression of Hsp90 and Hsp70 in the liver of diabetic rats and to compare it with the liver of control rats. A diabetic model was conducted using alloxan monohydrate (150 mg/kg). Immuno-histochemical staining for HSP70 and HSP90 was carried out using indirect immune-peroxidase protocol. Results showed that the expression of HSP90 in diabetic group was significantly upregulated compared with control group (p = 0.008), while the expression of HSP70 was downregulated in diabetic liver compared with control group (p = 0.000). Furthermore, the expression of HSP90 was more observed in vascular tissue of diabetic liver compared with the liver of control rats. The expression of HSP70 was observed in vascular system of both diabetic and control liver sections. Taken together, expression of HSP70 and HSP90 can be significantly associated with progression of diabetes and its vascular changes in the liver in induced diabetic animal model.

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Title: Diabetes upregulates the expression of HSP90 and downregulates HSP70 in the liver of diabetic rats
Authors: Kawther Faisal Amawi
Inas Saleh Al-Mazari
Ali Alsarhan
Hamza Qasim Mohammad Alhamad
Ahed J. Alkhatib
Publication date: 01-04-2019
Publisher: Springer London
Keyword: Type 2 Diabetes
Published in: Comparative Clinical Pathology / Issue 2/2019
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-019-02902-5

At a glance: The STEP trials

Springer Medicine

Diabetes upregulates the expression of HSP90 and downregulates HSP70 in the liver of diabetic rats

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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