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Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 5/2020

01-10-2020 | Proton Pump Inhibitors | Editorial

Should patients hold proton pump inhibitors prior to 82Rubidium positron emission tomography myocardial perfusion imaging?

Author: Mouaz H. Al-Mallah, MS, MSc

Published in: Journal of Nuclear Cardiology | Issue 5/2020

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Excerpt

In the recent years, there has been a clear shift toward increased utilization of cardiac positron emission tomography (PET) in myocardial perfusion imaging (MPI).1,2 This is seen in both the academic and private sectors. It is in part due to limited diagnostic accuracy of SPECT in the real world.3 Recent data suggested that SPECT performance outside clinical studies is limited by decreased specificity. PET MPI has been shown to have enhanced diagnostic accuracy in comparison to other imaging modalities.4 In the recent PACIFIC trial, cardiac PET had the highest accuracy and overall area under the curve when compared to other modalities using invasive hemodynamic assessment as the reference standard.5 …
Literature
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Al Badarin F, Aljizeeri A, Almasoudi F, Al-Mallah MH. Assessment of myocardial blood flow and coronary flow reserve with positron emission tomography in ischemic heart disease: Current state and future directions. Heart Fail Rev 2017;22:441-53.CrossRefPubMed
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Al-Mallah MH, Sitek A, Moore SC, Di Carli M, Dorbala S. Assessment of myocardial perfusion and function with PET and PET/CT. J Nucl Cardiol 2010;17:498-513.CrossRefPubMedPubMedCentral
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Chinnaiyan KM, Peyser P, Goraya T, Ananthasubramaniam K, Gallagher M, Depetris A, Boura JA, Kazerooni E, Poopat C, Al-Mallah M, Saba S, Patel S, Girard S, Song T, Share D, Raff G. Impact of a continuous quality improvement initiative on appropriate use of coronary computed tomography angiography. Results from a multicenter, statewide registry, the Advanced Cardiovascular Imaging Consortium. J Am Coll Cardiol 2012;60:1185-91.CrossRefPubMed
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Mc Ardle BA, Dowsley TF, deKemp RA, Wells GA, Beanlands RS. Does Rubidium-82 PET have superior accuracy to SPECT perfusion imaging for the diagnosis of obstructive coronary disease?: A systematic review and meta-analysis. J Am Coll Cardiol 2012;60:1828-37.CrossRefPubMed
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Danad I, Raijmakers PG, Driessen RS, Leipsic J, Raju R, Naoum C, Knuuti J, Mäki M, Underwood RS, Min JK, Elmore K, Stuijfzand WJ, van Royen N, Tulevski II, Somsen AG, Huisman MC, van Lingen AA, Heymans MW, van de Ven PM, van Kuijk C, Lammertsma AA, van Rossum AC, Knaapen P. Comparison of coronary CT angiography, SPECT, PET, and hybrid imaging for diagnosis of ischemic heart disease determined by fractional flow reserve. JAMA Cardiol 2017;2:1100-7.CrossRefPubMedPubMedCentral
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Dilsizian V, Bacharach SL, Beanlands RS, Bergmann SR, Delbeke D, Dorbala S, Gropler RJ, Knuuti J, Schelbert HR, Travin MI. ASNC imaging guidelines/SNMMI procedure standard for positron emission tomography (PET) nuclear cardiology procedures. J Nuclear Cardiol 2016;23:1187-226.CrossRef
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Orton EJ, Al Harbi I, Klein R, Beanlands RSB, deKemp RA, Glenn Wells R. Detection and severity classification of extracardiac interference in 82Rb PET myocardial perfusion imaging. Med Phys 2014;41:102501.CrossRefPubMed
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Jaynes M, Kumar AB. The risks of long-term use of proton pump inhibitors: A critical review. Ther Adv Drug Saf 2018;10:2042098618809927.PubMedPubMedCentral
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Cheung KS, Leung WK. Long-term use of proton-pump inhibitors and risk of gastric cancer: A review of the current evidence. Ther Adv Gastroenterol 2019;12:1756284819834511.CrossRef
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Alzahrani AH, Arasaratnam P, Massalha S, Alenazy A, Lee A, Clarkin O, deKemp RA, Hossain A, Beanlands RS, Ruddy TD, Chow BJW. Effect of proton pump inhibitors on Rubidium-82 gastric uptake using positron emission tomography myocardial perfusion imaging. J Nuclear Cardiol. 2019. https://​doi.​org/​10.​1007/​s12350-019-01954-y.CrossRef
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Rasmussen T, Kjær A, Hasbak P. Stomach interference in 82Rb-PET myocardial perfusion imaging. J Nuclear Cardiol 2018;26:1934-42.CrossRef
Metadata
Title
Should patients hold proton pump inhibitors prior to 82Rubidium positron emission tomography myocardial perfusion imaging?
Author
Mouaz H. Al-Mallah, MS, MSc
Publication date
01-10-2020
Publisher
Springer International Publishing
Published in
Journal of Nuclear Cardiology / Issue 5/2020
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-020-02072-w

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