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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2014

Open Access 01-12-2014 | Research article

Protective effect of exclusive breastfeeding against hand, foot and mouth disease

Authors: Hualiang Lin, Limei Sun, Jinyan Lin, Jianfeng He, Aiping Deng, Min Kang, Hanri Zeng, Wenjun Ma, Yonghui Zhang

Published in: BMC Infectious Diseases | Issue 1/2014

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Abstract

Background

Infants who are exclusively breastfed receive natural protection against some infectious agents. This study examined whether there was protective effect of exclusive breastfeeding on the occurrence of hand, foot and mouth disease, which was an emerging infectious disease among children in China.

Methods

A community-based case–control study was carried out among children age 4 years or younger in Guangdong Province, China. Cases were newly diagnosed hand, foot and mouth disease. Controls were randomly sampled from healthy children from the nearby village. Unconditional logistic regression model was used to estimate the odds ratio (OR) for exclusive breastfeeding after adjusting for potential confounding factors.

Results

A total of 316 cases and 566 controls were included in the analysis. Significantly beneficial effect of exclusive breastfeeding during the first 6 months was observed for hand, foot and mouth disease occurrence. The overall OR was 0.63 (95% CI: 0.47-0.85) for exclusive breastfeeding compared with mixed feeding type. The age-specific analyses indicated that the protective effect persisted till the age of 28 months.

Conclusions

This study suggests that exclusive breastfeeding might have protective effect against HFMD infection among the children within 28 months of age.
Appendix
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Metadata
Title
Protective effect of exclusive breastfeeding against hand, foot and mouth disease
Authors
Hualiang Lin
Limei Sun
Jinyan Lin
Jianfeng He
Aiping Deng
Min Kang
Hanri Zeng
Wenjun Ma
Yonghui Zhang
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2014
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-014-0645-6

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