Top

Supportive Care in Cancer

Published in:

01-06-2020 | Prostate Cancer | Original Article

Impact of the antifermentative diet during radiotherapy for prostate cancer in elderly, SÃO Paulo, Brazil

Authors: Érica Line de Oliveira Pedron, Rita de Cássia de Aquino, Claudia Borin da Silva

Published in: Supportive Care in Cancer | Issue 6/2020

Abstract

Objective

Assess the impact of the antifermentative diet on the dietary intake and body composition of elderly prostate cancer patients in radiotherapy.

Methods

Observational and prospective study involving 45 men aged 60 years or older, receiving radiotherapy for prostate cancer treatment. The dietary intake was assessed at four times during radiotherapy: onset (T_Pre), between the 11th and 16th day (T₁), between the 24th and 28th day (T₂), and on the last day (T_Last). The body composition was assessed before and on the last day of radiotherapy, by means of the body weight and height, mid-arm circumference, triceps and subscapular skin folds, phase angle, resistance, and reactance. The data were statistically treated, considering a 5% significance level.

Results

The intake of energy, dietary fibers, and some nutrients decreased during the radiotherapy (p < 0.05). The intake of vitamins E, B1, B2, and folate, of the minerals calcium, magnesium, potassium, sodium, and phosphorus, and of the amino acid leucine dropped when the four assessment times were compared (p < 0.05). As regards the body composition, an impact was observed at the end of the radiotherapy, with lower body weight, arm circumference, subscapular cutaneous fold, phase angle and reactance (p < 0.05).

Conclusion

The antifermentative diet negatively influenced the food consumption and body composition of elderly patients submitted to radiotherapy for prostate cancer.

World Health Organization (2016) Multisectoral action for a life course approach to healthy ageing: draft global strategy and plan of action on ageing and health. https://apps.who.int/iris/bitstream/handle/10665/252671/A69_17-en.pdf?sequence=1&isAllowed=y.

International Agency for Research on Cancer (2018) Estimated age-standardized mortality rates (World) in 2018, all cancers, males, all ages. http://gco.iarc.fr/today/online-analysis-map.

Mcnair HA, Wedlake L, Lips IM, Andreyev L, Vulpen MV, Dearnaley D (2014) A systematic review: effectiveness of rectal emptying preparation in prostate cancer patients. Practical Radiation Oncology 4:437–447. https://doi.org/10.1016/j.prro.2014.06.005 CrossRefPubMed

Smitsmans MHP, Pos FJ, Bois J, Heemsbergen WD, Sonke IJ, Leberque IV, Herk MV (2008) The influence of a dietary protocol on cone beam CT-guided radiotherapy for prostate cancer patients. I J Radiation Oncology Biol Phys 71(4):1279–1286. https://doi.org/10.1016/j.ijrobp.2008.03.036 CrossRef

American Cancer Society (2014) Low fiber foods. http://www.cancer.org/Treatment/SurvivorshipDuringandAfterTreatment/NutritionforPeoplewithCancer/low-fiber-foods.

Mayo Clinic (2014) Low-fiber diet. http://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/low-fiber-diet/art-20048511?pg=2.

Andreyev HJN, Muls AC, Norton C, Ralph C, Watson L, Shaw C, Lindsay JO (2015) Guidance: the practical management of the gastrointestinal symptoms of pelvic radiation disease. Frontline Gastroenterology 6:53–72 https://doi.org/10.1136/flgastro-2014-100468 CrossRefPubMed

Henson CC, Burden S, Davidson SE (2013) Nutritional intervention for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy. Cochrane Database of Systematic Review 26(11):1–47. https://doi.org/10.1002/14651858.CD009896.pub2/abstract

Ludlow H, Green J, Turner J (2017) Late gastrointestinal effects of pelvic radiation: a nurse-led service. Br J Nurs 26(4):15–22. https://doi.org/10.12968/bjon.2017.26.4.S15 CrossRef

10.

Kakodkar S, Mutlu EA (2017) Diet as a therapeutic option for adult inflammatory bowel disease. Gastroenterol Clin N Am 46:745–767. https://doi.org/10.1016/j.gtc.2017.08.016

11.

Wedlake LJ, Shaw C, Andreyev HJN (2013) Systematic review: the efficacy of nutritional intervention to counteract acute gastrointestinal toxicity during therapeutic pelvic radiotherapy. Aliment Pharmacol Ther 37:1046–1056. https://doi.org/10.1111/apt.12316 CrossRefPubMed

12.

Pair ML, Weiliang D, Rojas HD, Kanke JE, Mc Guirre SE, Lee AK, Kuban DA, Kudchacker RJ (2013) Dosimetric effects of weight loss or gain during volumetric modulated arc therapy and intensity-modulated radiation therapy for prostate cancer. Med Dosim 38:251–254. https://doi.org/10.1016/j.meddos.2013.02.004 CrossRefPubMed

13.

Oates RW, Schneider ME, Lim Joon M et al (2014) A randomised study of a diet intervention to maintain consistent rectal volume for patients receiving radical radiotherapy to the prostate. Acta Oncol 53(4):569–571. https://doi.org/10.3109/0284186X.2013.854927 CrossRefPubMed

14.

Petterson A, Nygren P, Persson C et al (2014) Effects of a dietary intervention on gastrointestinal symptoms after prostate cancer radiotherapy: long-term results from a randomized controlled trial. Radiother Oncol 113:240–247. https://doi.org/10.1016/j.radonc.2014.11.025 CrossRef

15.

Wedlake L, Shaw C, McNair H et al (2017) Randomized controlled trial of dietary fiber for the prevention of radiation-induced gastrointestinal toxicity during pelvic radiotherapy. Am J Clin Nutr. https://doi.org/10.3945/ajcn.116.150565

16.

Higuera-Pulgar I, Ribed A, Carrascal-Fabian ML, Bretón-Lesmes I, Romero-Jiménez RM, Cuerda-Compes C, Velasco-Gimeno C, Camblor-Álvarez M, García-Peris P (2015) Ingesta dietética y estado nutricional de pacientes oncológicos que inician tratamiento com inhibidores tirosina quisana. Nutr Hosp 32(3):1200–1207 https://doi.org/10.3305/nh.2015.32.3.9315 CrossRefPubMed

17.

Mardas M, Madry R, Stelmach-Mardas M (2016) Dietary intake variability in the cycle of cytotoxic chemotherapy. Support Care Cancer 24:2619–2625. https://doi.org/10.1007/s00520-015-3072-3 CrossRefPubMed

18.

Malihi Z, Kandiah M, Chan YM, Esfandbod M, VakilI M, Hosseinzadeh M, Zarif YM (2015) The effect of dietary intake changes on nutritional status in acute leukaemia patients after first induction chemotherapy. European Journal of Cancer Care 24:542–552. https://doi.org/10.1111/ecc.12262 CrossRefPubMed

19.

Silva HGV, Andrade CF, Moreira ASB (2014) Dietary intake and nutritional status in cancer patients: comparing adults and older adults. Nutr Hosp 29:907–912

20.

Volpi E, Campbell WW, Dwyer JT, Johnson MA, Jensen GL, Morley JE, Wolfe RR (2013) Is the optimal level of protein intake for older adults greater than the recommended dietary allowance? J Geront A Biol Sci Med 68(6):677–681 https://doi.org/10.1093/gerona/gls229 CrossRef

21.

Deutz NE, Bauer JM, Barazzoni R, Biolo G, Boirie Y, Bosy-Westphal A, Cederholm T, Cruz-Jentoft A, Krznariç Z, Nair KS, Singer P, Teta D, Tipton K, Calder PC (2014) Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group. Clin Nutr 33(6):929–936 https://doi.org/10.1016/j.clnu.2014.04.00 CrossRefPubMedPubMedCentral

22.

Custódio IDD, Marinho EC, Gontijo CA et al (2016) Impact of chemotherapy on diet and nutritional status of women with breast cancer: a prospective study. PLoS One. https://doi.org/10.1371/journal.pone.0157113

23.

Brasil. Resolução RDC no. 344 (2002) Regulamento técnico para a Fortificação das Farinhas de Trigo e das Farinhas de Milho com Ferro e Ácido Fólico. http://portalanvisagovbr/documents/10181/2718376/RDC_344_2002_COMPpdf Accessed 05 January 2018

24.

Lane JA, Oliver SE, Appleby PN et al (2017) Prostate cancer risk related to foods, food groups, macronutrients and micronutrients derives from the UK dietary cohort consortium food diaries. Eur J Clin Nutr 71:274–283. https://doi.org/10.1038/ejcn.2016.162 CrossRefPubMed

25.

Mardas M, Jamka M, Madry R, Walkowiak J, Krótkopad M, Stelmach-Mardas M (2014) Dietary habits changes and quality of life in patients undergoing chemotherapy for epithelial ovarian cancer. Support Care Cancer 23(4):1015–1023. https://doi.org/10.1007/s00520-014-2462-2 CrossRefPubMed

26.

Hilal Z, Rezniczek GA, Klenke R, Dogan A, Tempfer CB (2017) Nutritional status, cachexia, and anorexia in women with peritoneal metastasis and intraperitoneal chemotherapy: a longitudinal analysis. J Gynecol Oncol 28(6). https://doi.org/10.3802/jgo.2017.28.e80

27.

Schaap LA, Quirke T, Wijnhoven HAH, Visser M (2017) Changes in body mass index and mid-upper arm circumference in relation to all-cause mortality in older adults. Clin Nutr. https://doi.org/10.1016/j.clnu.2017.11.004

28.

Ravasco P, Monteiro-Grillo I, Vidal PM. Camilo ME (2005) Dietary counseling improves patient outcome: a prospective, randomized, controlled trial in colorectal patients undergoing radiotherapy. Clin Nutr Oncol 23 (7): 1431–1438. https://doi.org/10.1200/JCO.2005.02.054

29.

Motta RST, Castanho IA, Velarde LGC (2015) Cutoff point of the phase angle in pre-radiotherapy cancer patients. Nutr Hosp 32(5):2253–2260. https://doi.org/10.3305/nh.2015.32.5.9626

30.

Bourdel-Marchasson I, Diallo A, Bellera C, Blanc-Bisson C, Durrieu J, Germain C, Mathoulin-Pélissier S, Soubeyran P, Rainfray M, Fonck M, Doussau A (2016) One-year mortality in older patients with cancer: development and external validation of an MNA-based prognostic score. PLoS One 11(2). https://doi.org/10.1371/journal.pone.0148523

31.

Lundberg M, Nikander P, Tuominen K et al (2017) Bioelectrical impedance analysis of head and neck cancer patients at presentation. Acta Otolaryngol. https://doi.org/10.1080/00016489.2016.1266510

32.

Paixão EMS, Gonzales MC, Ito MK (2015) A prospective study on the radiation therapy associated changes in body weight and bioelectrical standardized phase angle. Clin Nutr 34:496–500. https://doi.org/10.1016/j.clnu.2014.05.012 CrossRefPubMed

33.

Whelan K, Martin LD, Staudacher HM, Lomer MCE (2018) The low FODMAP diet in the management of irritable bowel syndrome: an evidence-based review of FODMAP restriction, reintroduction and personalization in clinical practice. J Hum Nutr Diet 31:239–255. https://doi.org/10.1111/jhn.12530 CrossRefPubMed

Title: Impact of the antifermentative diet during radiotherapy for prostate cancer in elderly, SÃO Paulo, Brazil
Authors: Érica Line de Oliveira Pedron
Rita de Cássia de Aquino
Claudia Borin da Silva
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keywords: Prostate Cancer
Prostate Cancer
Radiotherapy
Published in: Supportive Care in Cancer / Issue 6/2020
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-019-05187-0

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 6/2020

Palliative sedation: beliefs and decision-making among Spanish palliative care physicians

Dyadic quality of life among heterosexual and sexual minority breast cancer survivors and their caregivers

Permanent chemotherapy-induced alopecia: awareness and attitudes among health care providers

Qualitative study on perceived dignity of cancer patients undergoing chemotherapy in China

Question prompts to empower cancer patients: results of a randomized controlled trial

Cost-effectiveness of an exercise and nutritional intervention versus usual nutritional care during adjuvant treatment for localized breast cancer: the PASAPAS randomized controlled trial

Keynote webinar | Spotlight on antibody–drug conjugates in cancer