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01-12-2019 | Prostate Cancer | Original Paper

Body size and dietary risk factors for aggressive prostate cancer: a case–control study

Authors: Mikaela Pal, Allison M. Hodge, Nathan Papa, Robert J. MacInnis, Julie K. Bassett, Damien Bolton, Ian D. Davis, Jeremy Millar, Dallas R. English, John L. Hopper, Gianluca Severi, Melissa C. Southey, Roger L. Milne, Graham G. Giles

Published in: Cancer Causes & Control | Issue 12/2019

Abstract

Purpose

Diet and body size may affect the risk of aggressive prostate cancer (APC), but current evidence is inconclusive.

Methods

A case–control study was conducted in men under 75 years of age recruited from urology practices in Victoria, Australia; 1,254 with APC and 818 controls for whom the presence of prostate cancer had been excluded by biopsy. Dietary intakes were assessed using a validated food frequency questionnaire. Multivariable unconditional logistic regression estimated odds ratios and confidence intervals for hypothesized risk factors, adjusting for age, family history of prostate cancer, country of birth, socioeconomic status, smoking, and other dietary factors.

Results

Positive associations with APC (odds ratio, 95% confidence intervals, highest vs. lowest category or quintile) were observed for body mass index (1.34, 1.02–1.78, P_trend = 0.04), and trouser size (1.54, 1.17–2.04, P_trend = 0.001). Intakes of milk and all dairy products were inversely associated with APC risk (0.71, 9.53–0.96, P_trend = 0.05, and 0.64, 0.48–0.87, P_trend = 0.012, respectively), but there was little evidence of an association with other dietary variables (P_trend > 0.05).

Conclusions

We confirmed previous evidence for a positive association between body size and risk of APC, and suggest that consumption of dairy products, and milk more specifically, is inversely associated with risk.

Australian Institute of Health and Welfare (2019) Cancer in Australia 2019. Cancer series no. 199. Cat. No. CAN 123. Canberra: AIHW

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries: Global Cancer Statistics 2018. CA Cancer J Clin 68(6):394–424. https://doi.org/10.3322/caac.21492 CrossRefPubMed

Giovannucci E, Liu Y, Platz EA, Stampfer MJ, Willett WC (2007) Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. Int J Cancer 121(7):1571–1578CrossRef

World Cancer Research Fund/American Institute for Cancer Research. Continuous Update Project Expert Report 2018. Diet, nutrition, physical activity and prostate cancer. https://dietandcancerreport.org

Leitzmann M, Rohrmann S (2012) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates. Clin Epidemiol. 4:1–11. https://doi.org/10.2147/CLEP.S16747 CrossRefPubMedPubMedCentral

Möller E, Wilson KM, Batista JL, Mucci LA, Bälter K, Giovannucci E (2016) Body size across the life course and prostate cancer in the Health Professionals Follow-up Study: Body size and prostate cancer. Int J Cancer. 138(4):853–865. https://doi.org/10.1002/ijc.29842 CrossRefPubMed

Giovannucci E, Rimm EB, Liu Y, Leitzmann M, Wu K, Stampfer MJ, et al (2003) Body mass index and risk of prostate cancer in U.S. health professionals. JNCI J Natl Cancer Inst. 95(16):1240–1244CrossRefPubMed

Gong Z, Neuhouser ML, Goodman PJ, Albanes D, Chi C, Hsing AW et al (2006) Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomark Prev 15(10):1977–1983CrossRef

Kelly SP, Lennon H, Sperrin M, Matthews C, Freedman ND, Albanes D et al (2018) Body mass index trajectories across adulthood and smoking in relation to prostate cancer risks: the NIH-AARP Diet and Health Study. Int J Epidemiol. https://doi.org/10.1093/ije/dyy/219 CrossRefPubMedCentral

10.

Antwi SO, Steck SE, Su LJ, Hebert JR, Zhang H, Craft NE et al (2016) Carotenoid intake and adipose tissue carotenoid levels in relation to prostate cancer aggressiveness among African-American and European-American men in the North Carolina-Louisiana prostate cancer project (PCaP): carotenoids and prostate cancer aggressiveness. Prostate 76(12):1053–1066. https://doi.org/10.1002/pros.23189 CrossRefPubMedPubMedCentral

11.

Giovannucci E, Rimm EB, Liu Y, Stampfer MJ, Willett WC (2002) A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst 94(5):391–398CrossRef

12.

Perez-Cornago A, Travis RC, Appleby PN, Tsilidis KK, Tjønneland A, Olsen A et al (2017) Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC): fruit, vegetable intake and prostate cancer risk. Int J Cancer 141(2):287–297. https://doi.org/10.1002/ijc.30741 CrossRefPubMedPubMedCentral

13.

Hardin J, Cheng I, Witte JS (2011) Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk. Nutr Cancer 63(6):860–872. https://doi.org/10.1080/01635581.2011.582224 CrossRefPubMedPubMedCentral

14.

Kirsh VA, Peters U, Mayne ST, Subar AF, Chatterjee N, Johnson CC et al (2007) Prospective study of fruit and vegetable intake and risk of prostate cancer. JNCI J Natl Cancer Inst 99(15):1200–1209CrossRef

15.

Liu B, Mao Q, Cao M, Xie L (2012) Cruciferous vegetables intake and risk of prostate cancer: a meta-analysis: cruciferous vegetables and prostate cancer. Int J Urol 19(2):134–141. https://doi.org/10.1111/j.1442-2042.2011.02906.x CrossRefPubMed

16.

Zhou X-F, Ding Z-S, Liu N-B (2013) Allium vegetables and risk of prostate cancer: evidence from 132,192 subjects. Asian Pac J Cancer Prev 14(7):4131–4134CrossRef

17.

Hsing AW, Chokkalingam AP, Gao YT, Madigan MP, Deng J, Gridley G et al (2002) Allium vegetables and risk of prostate cancer: a population-based study. J Natl Cancer Inst 94(21):1648–1651CrossRef

18.

Lovegrove C, Ahmed K, Challacombe B, Khan MS, Popert R, Dasgupta P (2015) Systematic review of prostate cancer risk and association with consumption of fish and fish-oils: analysis of 495,321 participants. Int J Clin Pract 69(1):87–105. https://doi.org/10.1111/ijcp.12514 CrossRefPubMed

19.

Augustsson K, Michaud DS, Rimm EB, Leitzmann MF, Stampfer MJ, Willett WC et al (2003) A prospective study of intake of fish and marine fatty acids and prostate cancer. Cancer Epidemiol Biomark Prev 12(1):64–67

20.

Wu K, Spiegelman D, Hou T, Albanes D, Allen NE, Berndt SI et al (2016) Associations between unprocessed red and processed meat, poultry, seafood and egg intake and the risk of prostate cancer: a pooled analysis of 15 prospective cohort studies: meat, seafood, eggs and prostate cancer. Int J Cancer 138(10):2368–2382. https://doi.org/10.1002/ijc.29973 CrossRefPubMedPubMedCentral

21.

Wilson KM, Mucci LA, Drake BF, Preston MA, Stampfer MJ, Giovannucci E et al (2016) Meat, fish, poultry, and egg intake at diagnosis and risk of prostate cancer progression. Cancer Prev Res (Phila) 9(12):933–941CrossRef

22.

Aune D, Navarro Rosenblatt DA, Chan DS, Vieira AR, Vieira R, Greenwood DC et al (2015) Dairy products, calcium, and prostate cancer risk: a systematic review and meta-analysis of cohort studies. Am J Clin Nutr 101(1):87–117. https://doi.org/10.3945/ajcn.113.067157 CrossRefPubMed

23.

Steck SE, Omofuma OO, Su LJ, Maise AA, Woloszynska-Read A, Johnson CS et al (2018) Calcium, magnesium, and whole-milk intakes and high-aggressive prostate cancer in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Am J Clin Nutr 107(5):799–807. https://doi.org/10.1093/ajcn/nqy037 CrossRefPubMed

24.

Giovannucci E, Liu Y, Stampfer MJ, Willett WC (2006) A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomark Prev 15(2):203–210CrossRef

25.

Batai K, Murphy AB, Ruden M, Newsome J, Shah E, Dixon MA et al (2017) Race and BMI modify associations of calcium and vitamin D intake with prostate cancer. BMC Cancer 17(1):64. https://doi.org/10.1186/s12885-017-3060-8 CrossRefPubMedPubMedCentral

26.

Petimar J, Wilson KM, Wu K, Wang M, Albanes D, van den Brandt PA et al (2017) A pooled analysis of 15 prospective cohort studies on the association between fruit, vegetable, and mature bean consumption and risk of prostate cancer. Cancer Epidemiol Biomark Prev 26(8):1276–1287. https://doi.org/10.1158/1055-9965.EPI-16-1006 CrossRef

27.

Lane JA, Oliver SE, Appleby PN, Lentjes MAH, Emmett P, Kuh D et al (2017) Prostate cancer risk related to foods, food groups, macronutrients and micronutrients derived from the UK Dietary Cohort Consortium food diaries. Eur J Clin Nutr 71(2):274–283. https://doi.org/10.1038/ejcn.2016.162 CrossRefPubMed

28.

Key TJ, Allen N, Appleby P, Overvad K, Tjønneland A, Miller A et al (2004) Fruits and vegetables and prostate cancer: no association among 1,104 cases in a prospective study of 130,544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC): fruits and vegetables and prostate cancer. Int J Cancer 109(1):119–124CrossRef

29.

Stram DO, Hankin JH, Wilkens LR, Park S, Henderson BE, Nomura AM et al (2006) Prostate cancer incidence and intake of fruits, vegetables and related micronutrients: the multiethnic cohort study (United States). Cancer Causes Control 17:1193–1207CrossRef

30.

Takachi R, Inoue M, Sawanda N, Iwasaki M, Sasazuki S, Ishihara J et al (2010) Fruits and vegetables in relation to prostate cancer in Japanese men: the Japan Public Health Center-Based Prospective Study. Nutr Cancer 62(1):30–39. https://doi.org/10.1080/01635580903191502 CrossRefPubMed

31.

Bylsma LC, Alexander DD (2015) A review and meta-analysis of prospective studies of red and processed meat, meat cooking methods, heme iron, heterocyclic amines and prostate cancer. Nutr J 14:125. https://doi.org/10.1186/s12937-015-0111-3 CrossRefPubMedPubMedCentral

32.

Rohrmann S, Platz EA, Kavanaugh CJ, Thuita L, Hoffman SC, Helzlsouer KJ (2007) Meat and dairy consumption and subsequent risk of prostate cancer in a US cohort study. Cancer Causes Control 18(1):41–50CrossRef

33.

Allen NE, Key TJ, Appleby PN, Travis RC, Roddam AW, Tjønneland A et al (2008) Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition. Br J Cancer 98(9):1574–1581. https://doi.org/10.1038/sj.bjc.6604331 CrossRefPubMedPubMedCentral

34.

Bassett JK, English DR, Fahey MT, Forbes AB, Gurrin LC, Simpson JA et al (2016) Validity and calibration of the FFQ used in the Melbourne Collaborative Cohort Study. Public Health Nutr 19(13):2357–2368. https://doi.org/10.1017/S1368980016000690 CrossRefPubMed

35.

Food Standards Australia New Zealand NUTTAB (2010) https://www.foodstandards.gov.au/science/monitoringnutrients/nutrientables/nuttab/Pages/NUTTAB-2010-electronic-database-files.aspx. Accessed Aug 2013

36.

Food Standards Australia New Zealand AUSNUT (2007) https://www.foodstandards.gov.au/science/monitoringnutrients/ausnut/Pages/ausnut2007.aspx. Accessed Aug 2013

37.

US Department of Agriculture, Agricultural Research Service (2013) USDA National Nutrient Database for Standard Reference, Release 26. Nutrient Data Laboratory Home Page. https://www.ars.usda.gov/ba/bhnrc/ndl. Accessed Aug 2013

38.

Australian Bureau of Statistics (2011) Census of population and housing: Socio-Economic Indexes for Areas (SEIFA), Australia, 2011. https://www.abs.gov.au/ausstats/abs@.nsf/mf/2033.0.55.001. Accessed 3 June 2016

39.

Huang CS, Chuang CH, Lo TF, Hu ML (2013) Anti-angiogenic effects of lycopene through immunomodulation of cytokine secretion in human peripheral blood mononuclear cells. J Nutr Biochem 24(2):428–434. https://doi.org/10.1016/j.jnutbio.2012.01.003 CrossRefPubMed

40.

Chen M-L, Lin Y-H, Yang C-M, Hu M-L (2012) Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways. Mol Nutr Food Res 56(6):889–899. https://doi.org/10.1002/mnfr.201100683 CrossRefPubMed

41.

Liu RH (3485S) Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr 134(12 Suppl):3479S–3485S. https://doi.org/10.1093/jn/134.12.3479S CrossRefPubMed

42.

Steinmetz KA, Potter JD (1991) Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes Control 2(6):427–442CrossRef

43.

Dashwood RH, Myzak MC, Ho E (2006) Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? Carcinogenesis 27(2):344–349CrossRef

44.

Vivar OI, Lin C-L, Firestone GL, Bjeldanes LF (2009) 3,3′-Diindolylmethane induces a G1 arrest in human prostate cancer cells irrespective of androgen receptor and p53 status. Biochem Pharmacol 78(5):469–476. https://doi.org/10.1016/j.bcp.2009.05.008 CrossRefPubMedPubMedCentral

45.

Kolonel LN, Hankin JH, Whittemore AS, Wu AH, Gallagher RP, Wilkens LR et al (2000) Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol Biomark Prev 9(8):795–804

46.

Cohen JH, Kristal AR, Stanford JL (2000) Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 92(1):61–68CrossRef

47.

World Cancer Research Fund/American Institute for Cancer Research (2011) Continuous update project report. Food, nutrition, physical activity, and the prevention of colorectal cancer

48.

Bouvard V, Loomis D, Guyton KZ, Grosse Y, Ghissassi FE, Benbrahim-Tallaa L et al (2015) Carcinogenicity of consumption of red and processed meat. Lancet Oncol 16(16):1599–1600. https://doi.org/10.1016/S1470-2045(15)00444-1 CrossRefPubMed

49.

Diallo A, Deschasaux M, Latino-Martel P, Hercberg S, Galan P, Fassier P et al (2018) Red and processed meat intake and cancer risk: results from the prospective NutriNet-Santé cohort study: red and processed meat intake and cancer risk. Int J Cancer 142(2):230–237. https://doi.org/10.1002/ijc.31046 CrossRefPubMed

50.

Fradet V, Cheng I, Casey G, Witte JS (2009) Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. Clin Cancer Res 15(7):2559–2566. https://doi.org/10.1158/1078-0432.CCR-08-2503 CrossRefPubMedPubMedCentral

51.

Pelser C, Mondul AM, Hollenbeck AR, Park Y (2013) Dietary fat, fatty acids, and risk of prostate cancer in the NIH-AARP diet and health study. Cancer Epidemiol Biomark Prev 22(4):697–707. https://doi.org/10.1158/1055-9965.EPI-12-1196-T CrossRef

52.

Leitzmann MF, Stampfer MJ, Michaud DS, Augustsson K, Colditz GC, Willett WC et al (2004) Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. Am J Clin Nutr 80(1):204–216CrossRef

53.

Liang P, Henning SM, Schokrpur S, Wu L, Doan N, Said J et al (2016) Effect of dietary omega-3 fatty acids on tumor-associated macrophages and prostate cancer progression: fish oil and tumor-associated macrophages. Prostate 76(14):1293–1302. https://doi.org/10.1002/pros.23218 CrossRefPubMedPubMedCentral

54.

Saw CL, Wu TY, Paredes-Gonzalez X, Khor TO, Pung D, Kong AN (2011) Pharmacodynamics of fish oil: protective effects against prostate cancer in TRAMP mice fed with a high fat western diet. Asian Pac J Cancer Prev 12(12):3331–3334PubMed

55.

Lloyd JC, Masko EM, Wu C, Keenan MM, Pilla DM, Aronson WJ et al (2013) Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression. Prostate Cancer Prostatic Dis 16(4):285–291. https://doi.org/10.1038/pcan.2013.19 CrossRefPubMedPubMedCentral

56.

Meng H, Shen Y, Shen J, Zhou F, Shen S, Das UN (2013) Effect of n-3 and n-6 unsaturated fatty acids on prostate cancer (PC-3) and prostate epithelial (RWPE-1) cells in vitro. Lipids Health Dis 12(1):160. https://doi.org/10.1186/1476-511X-12-160 CrossRefPubMedPubMedCentral

57.

Liu Z, Hopkins MM, Zhang Z, Quisenberry CB, Fix LC, Galvan BM et al (2015) Omega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cells. J Pharmacol Exp Ther 352(2):380–394. https://doi.org/10.1124/jpet.114.218974 CrossRefPubMedPubMedCentral

58.

Chan JM, Stampfer MJ, Ma J, Gann PH, Gaziano JM, Giovannucci EL (2001) Dairy products, calcium, and prostate cancer risk in the Physicians’ Health Study. Am J Clin Nutr 74(4):549–554CrossRef

59.

Michaud DS, Augustsson K, Rimm EB, Stampfer MJ, Willett WC, Giovannucci E (2001) A prospective study on intake of animal products and risk of prostate cancer. Cancer Causes Control 12(6):557–567CrossRef

60.

Hodge AM, English DR, McCredie MRE, Severi G, Boyle P, Hopper JL et al (2004) Foods, nutrients and prostate cancer. Cancer Causes Control 15(1):11–20CrossRef

61.

Rodriguez C, McCullough ML, Mondul AM, Jacobs EJ, Fakhrabadi-Shokoohi D, Giovannucci EL et al (2003) Calcium, dairy products, and risk of prostate cancer in a prospective cohort of United States men. Cancer Epidemiol Prev Biomark 12(7):597–603

62.

Koh KA, Sesso HD, Paffenbarger RS, Lee I-M (2006) Dairy products, calcium and prostate cancer risk. Br J Cancer 95(11):1582–1585CrossRef

63.

World Cancer Research Fund/American Institute for Cancer Research (2018) Meat, fish and dairy products and the risk of cancer: continuous update project expert report 2018. https://dietandcancerreport.org

64.

Ahn J, Albanes D, Peters U, Schatzkin A, Lim U, Freedman M et al (2007) Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomark Prev 16(12):2623–2630CrossRef

65.

Littlejohns TJ, Travis RC, Key TJ, Allen NE (2016) Lifestyle factors and prostate-specific antigen (PSA) testing in UK Biobank: implications for epidemiological research. Cancer Epidemiol 45:40–46. https://doi.org/10.1016/j.canep.2016.09.010 CrossRefPubMedPubMedCentral

66.

Pernar CH, Ebot EM, Wilson KM, Mucci LA (2018) The epidemiology of prostate cancer. Cold Spring Harb Perspect Med. https://doi.org/10.1101/cshperspect.a030361 CrossRefPubMed

Title: Body size and dietary risk factors for aggressive prostate cancer: a case–control study
Authors: Mikaela Pal
Allison M. Hodge
Nathan Papa
Robert J. MacInnis
Julie K. Bassett
Damien Bolton
Ian D. Davis
Jeremy Millar
Dallas R. English
John L. Hopper
Gianluca Severi
Melissa C. Southey
Roger L. Milne
Graham G. Giles
Publication date: 01-12-2019
Publisher: Springer International Publishing
Keywords: Prostate Cancer
Prostate Cancer
Published in: Cancer Causes & Control / Issue 12/2019
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-019-01234-7

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