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European Journal of Nuclear Medicine and Molecular Imaging

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01-05-2019 | Prostate Cancer | Original Article

⁶⁸Ga-PSMA PET/CT for monitoring response to ¹⁷⁷Lu-PSMA-617 radioligand therapy in patients with metastatic castration-resistant prostate cancer

Authors: Alexander Heinzel, Dima Boghos, Felix M. Mottaghy, Florian Gaertner, Markus Essler, Dirk von Mallek, Hojjat Ahmadzadehfar

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 5/2019

Abstract

Purpose

To evaluate the use of ⁶⁸Ga-PSMA PET/CT for monitoring response to ¹⁷⁷Lu-617 PSMA radioligand therapy in patients with metastatic castrate-resistant prostate cancer (mCRPC).

Methods

Patients from the University Hospital Bonn and the University Hospital Aachen were retrospectively reviewed for this study. We included 48 patients with mCRPC who were treated with ¹⁷⁷Lu-PSMA-617 and whose records included ⁶⁸Ga-PSMA PET/CT imaging before the first and after the third or fourth treatment cycle. A treatment response based on ⁶⁸Ga-PSMA PET/CT was defined according to a modified version of the PERCIST criteria. A decline in PSA level of ≥50% was considered the reference standard. The sensitivity, specificity, positive and negative predictive values, and ROC curves were calculated, and patient survival times in relation to the PET results were also analysed.

Results

⁶⁸Ga-PSMA PET/CT had a sensitivity of about 85% and a specificity of between 55% and 65%. The negative and positive predictive values ranged between 70% and 78%. The fitted ROC area was 0.70. The survival time was about 19.6 months in patients with a treatment response, while nonresponders had a survival time of about 15.9 months. However, this difference between the groups was not statistically significant.

Conclusion

Our results indicate that ⁶⁸Ga-PSMA PET/CT could be a useful tool for the evaluation of response to ¹⁷⁷Lu-PSMA-617 radioligand therapy within a theranostic framework.

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Title: 68Ga-PSMA PET/CT for monitoring response to 177Lu-PSMA-617 radioligand therapy in patients with metastatic castration-resistant prostate cancer
Authors: Alexander Heinzel
Dima Boghos
Felix M. Mottaghy
Florian Gaertner
Markus Essler
Dirk von Mallek
Hojjat Ahmadzadehfar
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Keywords: Prostate Cancer
Prostate Cancer
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 5/2019
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-019-4258-6

At a glance: The STEP trials

Springer Medicine

⁶⁸Ga-PSMA PET/CT for monitoring response to ¹⁷⁷Lu-PSMA-617 radioligand therapy in patients with metastatic castration-resistant prostate cancer

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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