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Open Access 01-10-2020 | Prostate Cancer | Original Contribution

A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

Authors: Nikos Papadimitriou, David Muller, Piet A. van den Brandt, Milan Geybels, Chirag J. Patel, Marc J. Gunter, David S. Lopez, Timothy J. Key, Aurora Perez-Cornago, Pietro Ferrari, Paolo Vineis, Elisabete Weiderpass, Heiner Boeing, Antonio Agudo, María-José Sánchez, Kim Overvad, Tilman Kühn, Renee T. Fortner, Domenico Palli, Isabel Drake, Anders Bjartell, Carmen Santiuste, Bas H. Bueno-de-Mesquita, Vittorio Krogh, Anne Tjønneland, Dorthe Furstrand Lauritzen, Aurelio Barricarte Gurrea, José Ramón Quirós, Pär Stattin, Antonia Trichopoulou, Georgia Martimianaki, Anna Karakatsani, Elin Thysell, Ingegerd Johansson, Fulvio Ricceri, Rosario Tumino, Nerea Larrañaga, Kay Tee Khaw, Elio Riboli, Ioanna Tzoulaki, Konstantinos K. Tsilidis

Published in: European Journal of Nutrition | Issue 7/2020

Abstract

Purpose

The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive.

Methods

A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS).

Results

A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS.

Conclusions

Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.

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Title: A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study
Authors: Nikos Papadimitriou
David Muller
Piet A. van den Brandt
Milan Geybels
Chirag J. Patel
Marc J. Gunter
David S. Lopez
Timothy J. Key
Aurora Perez-Cornago
Pietro Ferrari
Paolo Vineis
Elisabete Weiderpass
Heiner Boeing
Antonio Agudo
María-José Sánchez
Kim Overvad
Tilman Kühn
Renee T. Fortner
Domenico Palli
Isabel Drake
Anders Bjartell
Carmen Santiuste
Bas H. Bueno-de-Mesquita
Vittorio Krogh
Anne Tjønneland
Dorthe Furstrand Lauritzen
Aurelio Barricarte Gurrea
José Ramón Quirós
Pär Stattin
Antonia Trichopoulou
Georgia Martimianaki
Anna Karakatsani
Elin Thysell
Ingegerd Johansson
Fulvio Ricceri
Rosario Tumino
Nerea Larrañaga
Kay Tee Khaw
Elio Riboli
Ioanna Tzoulaki
Konstantinos K. Tsilidis
Publication date: 01-10-2020
Publisher: Springer Berlin Heidelberg
Keywords: Prostate Cancer
Nutrition
Prostate Cancer
Published in: European Journal of Nutrition / Issue 7/2020
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-02132-z

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