Skip to main content
Top
Published in: Drugs & Aging 5/2000

01-05-2000 | Leading Article

Prospects for Vaccination in Prostate Cancer

Authors: Matthew J. A. Perry, David Hrouda, Angus G. Dalgleish

Published in: Drugs & Aging | Issue 5/2000

Login to get access

Abstract

Prostate cancer continues to be a major cause of morbidity and mortality. Surgical and medical management of the disease has improved but there is little effect upon overall survival. Novel therapies such as immunotherapy offer the potential of treating the disease by stimulating the immune system to mount a response to the cancer systemically. This review highlights the pitfalls and progress in the understanding of the role of the immune system in malignancy and also explains the theory behind prostate cancer vaccine trials.
Literature
1.
go back to reference Coley WB. The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893. Clin Orthop 1991; 262: 3–11PubMed Coley WB. The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893. Clin Orthop 1991; 262: 3–11PubMed
2.
go back to reference Bumet FM. Immunological surveillance. Oxford: Pergamon Press, 1970 Bumet FM. Immunological surveillance. Oxford: Pergamon Press, 1970
3.
go back to reference Vesalainen S, Lipponen R, Talja M, et al. Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis inprostatic adenocarcinoma. Eur J Cancer 1994; 30A(12): 1797–803PubMedCrossRef Vesalainen S, Lipponen R, Talja M, et al. Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis inprostatic adenocarcinoma. Eur J Cancer 1994; 30A(12): 1797–803PubMedCrossRef
4.
go back to reference Bostwick DG, Conica FA, Dundore P, et al. Intraepithelial and stromal lymphocytes in the human prostate [abstract]. J Urol 1998; 159(5 Suppl.): 126 Bostwick DG, Conica FA, Dundore P, et al. Intraepithelial and stromal lymphocytes in the human prostate [abstract]. J Urol 1998; 159(5 Suppl.): 126
5.
go back to reference Merrin C, Han T, Klein E, et al. Immunotherapy of prostatic cancer with Bacillus Calmette-Guerin and purified protein derivative: preliminary results. Urology 1973; 2(6): 651–4PubMedCrossRef Merrin C, Han T, Klein E, et al. Immunotherapy of prostatic cancer with Bacillus Calmette-Guerin and purified protein derivative: preliminary results. Urology 1973; 2(6): 651–4PubMedCrossRef
6.
go back to reference Guinan R, Toronchi E, Shaw M, et al. Bacillus calmette-guerin (BCG) adjuvant therapy in stage D prostate cancer. Urology 1982; 20(4): 401–3PubMedCrossRef Guinan R, Toronchi E, Shaw M, et al. Bacillus calmette-guerin (BCG) adjuvant therapy in stage D prostate cancer. Urology 1982; 20(4): 401–3PubMedCrossRef
7.
go back to reference Hrouda D, Dalgleish AG. Gene therapy for prostate cancer. Gene Ther 1996; 3(10): 845–52PubMed Hrouda D, Dalgleish AG. Gene therapy for prostate cancer. Gene Ther 1996; 3(10): 845–52PubMed
8.
go back to reference van der Bruggen P, Traversari C, Chomez R, et al. A gene encoding an antigen recognised by cytolytic T lymphocytes on a human melanoma. Science 1991; 254: 1643–7PubMedCrossRef van der Bruggen P, Traversari C, Chomez R, et al. A gene encoding an antigen recognised by cytolytic T lymphocytes on a human melanoma. Science 1991; 254: 1643–7PubMedCrossRef
9.
go back to reference Coulle PG. Human tumor antigens recognised by cytolytic T lymphocytes. In: Dalgleish AG, Browning M, editors. Tumor immunology. Cambridge, England: Cambridge Press, 1996: 95–125 Coulle PG. Human tumor antigens recognised by cytolytic T lymphocytes. In: Dalgleish AG, Browning M, editors. Tumor immunology. Cambridge, England: Cambridge Press, 1996: 95–125
10.
go back to reference Israeli RS, Powell CT, Corr JG, et al. Expression of the prostate-specific membrane antigen. Cancer Res 1994; 54(7): 1807–11PubMed Israeli RS, Powell CT, Corr JG, et al. Expression of the prostate-specific membrane antigen. Cancer Res 1994; 54(7): 1807–11PubMed
11.
go back to reference Tjoa B, Boynton A, Kenny G, et al. Presentation of prostate tumor antigens by dendritic cells stimulates T-cell proliferation and cytotoxicity. Prostate 1996; 28(1): 65–9PubMedCrossRef Tjoa B, Boynton A, Kenny G, et al. Presentation of prostate tumor antigens by dendritic cells stimulates T-cell proliferation and cytotoxicity. Prostate 1996; 28(1): 65–9PubMedCrossRef
12.
go back to reference Corman JM, Sercarz ES, Nanda NK. Recognition of prostate-specific antigenic peptide determinants by human CD4 and CD8 T cells. Clin Exp Immunol 1998; 114(2): 166–72PubMedCrossRef Corman JM, Sercarz ES, Nanda NK. Recognition of prostate-specific antigenic peptide determinants by human CD4 and CD8 T cells. Clin Exp Immunol 1998; 114(2): 166–72PubMedCrossRef
13.
go back to reference Correale RP, Walmsley K, Nieroda C, et al. In vitro generation of human cytotoxic T lymphocytes specific for peptides derived from prostate-specific antigen. J Natl Cancer Inst 1997; 89(4): 293–300PubMedCrossRef Correale RP, Walmsley K, Nieroda C, et al. In vitro generation of human cytotoxic T lymphocytes specific for peptides derived from prostate-specific antigen. J Natl Cancer Inst 1997; 89(4): 293–300PubMedCrossRef
14.
go back to reference Brenner PC, Rettig WJ, Sanz-Moncasi MP, et al. TAG-72 expression in primary, metastatic and hormonally treated prostate cancer as defined by monoclonal antibody CC49. J Urol 1995; 153(5): 1575–9PubMedCrossRef Brenner PC, Rettig WJ, Sanz-Moncasi MP, et al. TAG-72 expression in primary, metastatic and hormonally treated prostate cancer as defined by monoclonal antibody CC49. J Urol 1995; 153(5): 1575–9PubMedCrossRef
15.
go back to reference Zliang S, Zliang HS, Reuter VE, et al. Expression of potential target antigens for immunotherapy on primary and metastatic prostate cancers. Clin Cancer Res 1998; 4(2): 295–302 Zliang S, Zliang HS, Reuter VE, et al. Expression of potential target antigens for immunotherapy on primary and metastatic prostate cancers. Clin Cancer Res 1998; 4(2): 295–302
16.
go back to reference Zinkernagel RM, Doherty PC. MHC restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T cell restriction specificity, function and responsiveness. Adv Immunol 1979; 26: 51–177CrossRef Zinkernagel RM, Doherty PC. MHC restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T cell restriction specificity, function and responsiveness. Adv Immunol 1979; 26: 51–177CrossRef
17.
go back to reference Blades RA, Keating PJ, McWilliam LJ, et al. Loss of HLA class I expression in prostate cancer: implications for immunotherapy. Urology 1995; 46(5): 681–6PubMedCrossRef Blades RA, Keating PJ, McWilliam LJ, et al. Loss of HLA class I expression in prostate cancer: implications for immunotherapy. Urology 1995; 46(5): 681–6PubMedCrossRef
18.
go back to reference Restifo NR, Kawakami Y, Marincola F, et al. Molecular mechanisms used by tumors to escape recognition: immunogenetherapy and the cell biology of major histocompatibility complex class I. J Immunother 1993; 142: 182–90CrossRef Restifo NR, Kawakami Y, Marincola F, et al. Molecular mechanisms used by tumors to escape recognition: immunogenetherapy and the cell biology of major histocompatibility complex class I. J Immunother 1993; 142: 182–90CrossRef
19.
go back to reference Restifo NP, Wang M. Antigen processing and presentation. In: Dalgleish AG, Browning M, editors. Tumor immunology. Cambridge, England: Cambridge Press, 1996: 39–69 Restifo NP, Wang M. Antigen processing and presentation. In: Dalgleish AG, Browning M, editors. Tumor immunology. Cambridge, England: Cambridge Press, 1996: 39–69
20.
go back to reference Rosenberg SA, Blaese RM, Brenner MK, et al. Human gene marker/therapy clinical protocols. Hum Gene Ther 1997; 8(18): 2301–38PubMedCrossRef Rosenberg SA, Blaese RM, Brenner MK, et al. Human gene marker/therapy clinical protocols. Hum Gene Ther 1997; 8(18): 2301–38PubMedCrossRef
21.
go back to reference Murphy G, Tjoa B, Ragde R, et al. Phase 1 clinical trial: T-cell therapy for prostate cancer using autologous dendritic cells pulsed with HLA-A020 1-specific peptides from prostate-specific membrane antigen. Prostate 1996; 29(6): 371–80PubMedCrossRef Murphy G, Tjoa B, Ragde R, et al. Phase 1 clinical trial: T-cell therapy for prostate cancer using autologous dendritic cells pulsed with HLA-A020 1-specific peptides from prostate-specific membrane antigen. Prostate 1996; 29(6): 371–80PubMedCrossRef
22.
go back to reference Chakraborty NG, Sporn JR, Tortora AR, et al. Immunization with a tumor-cell-lysate-loaded autologous-antigen-presenting-cell-based vaccine in melanoma. Cancer Immunol Im-munother 1998; 47(1): 58–64CrossRef Chakraborty NG, Sporn JR, Tortora AR, et al. Immunization with a tumor-cell-lysate-loaded autologous-antigen-presenting-cell-based vaccine in melanoma. Cancer Immunol Im-munother 1998; 47(1): 58–64CrossRef
23.
go back to reference Hsti FJ, Benike C, Fagoni F, et al. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat Med 1996; 2: 52–8CrossRef Hsti FJ, Benike C, Fagoni F, et al. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat Med 1996; 2: 52–8CrossRef
24.
go back to reference Kwon ED, Hurwitz AA, Foster BA, et al. Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer. Proc Natl Acad Sci U S A 1997 Jul 22; 94(15): 8099–103PubMedCrossRef Kwon ED, Hurwitz AA, Foster BA, et al. Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer. Proc Natl Acad Sci U S A 1997 Jul 22; 94(15): 8099–103PubMedCrossRef
25.
go back to reference Daniel PT, Kroidal A, Cayeux S, et al. Costimulatory signals through 137. 1/CD28 prevent T cell apoptosis during target cell lysis. J Immunol 1997; 159: 3808–15PubMed Daniel PT, Kroidal A, Cayeux S, et al. Costimulatory signals through 137. 1/CD28 prevent T cell apoptosis during target cell lysis. J Immunol 1997; 159: 3808–15PubMed
26.
go back to reference Parney IE, Petruk KC, Zliang C, et al. Granulocyte-macrophage colony-stimulating factor and B7-2 combination immunogene therapy in an allogeneic Hu-PBL-SCID/beige mouse-human glioblastoma multiforme model. Hum Gene Ther 1997; 8(9): 1073–85PubMedCrossRef Parney IE, Petruk KC, Zliang C, et al. Granulocyte-macrophage colony-stimulating factor and B7-2 combination immunogene therapy in an allogeneic Hu-PBL-SCID/beige mouse-human glioblastoma multiforme model. Hum Gene Ther 1997; 8(9): 1073–85PubMedCrossRef
28.
go back to reference Lucey DR, Clerici M, Shearer GM. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin Microbiol Rev 1996; 9(4): 532–62PubMed Lucey DR, Clerici M, Shearer GM. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin Microbiol Rev 1996; 9(4): 532–62PubMed
29.
go back to reference Pellegrini R, Berghella AM, Del Beato T, et al. Dysregulation in THI and TH2 subsets of CD4+ T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression. Cancer Immunol Immunother 1996; 42(1): 1–8PubMedCrossRef Pellegrini R, Berghella AM, Del Beato T, et al. Dysregulation in THI and TH2 subsets of CD4+ T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression. Cancer Immunol Immunother 1996; 42(1): 1–8PubMedCrossRef
30.
go back to reference Sato M, Goto S, Kaneko R, et al. Impaired production of Thl cytokines and increased frequency of Th2 subsets in PBMC from advanced cancer patients. Anticancer Res 1998; 18(5D): 3951–5PubMed Sato M, Goto S, Kaneko R, et al. Impaired production of Thl cytokines and increased frequency of Th2 subsets in PBMC from advanced cancer patients. Anticancer Res 1998; 18(5D): 3951–5PubMed
31.
go back to reference Lowes MA, Bishop GA, Crotty K, et al. T helper 1 cytokine mRNAis increased in spontaneously regressing primary melanomas. J Invest Dermatol 1997; 108(6): 914–9PubMedCrossRef Lowes MA, Bishop GA, Crotty K, et al. T helper 1 cytokine mRNAis increased in spontaneously regressing primary melanomas. J Invest Dermatol 1997; 108(6): 914–9PubMedCrossRef
32.
go back to reference Wagner SN, Schultewolter T, Wagner C, et al. Immune response against human primary malignant melanoma: a distinct cytokine mRNA profile associated with spontaneous regression. Lab Invest 1998; 78(5): 541–50PubMed Wagner SN, Schultewolter T, Wagner C, et al. Immune response against human primary malignant melanoma: a distinct cytokine mRNA profile associated with spontaneous regression. Lab Invest 1998; 78(5): 541–50PubMed
33.
go back to reference Hu HM, Urba WJ, Fox BA. Gene-modified tumor vaccine with therapeutic potential shifts tumor-specific T cell response from a type 2 to a type 1 cytokine profile. J Immunol 1998; 161(6): 3033–4lPubMed Hu HM, Urba WJ, Fox BA. Gene-modified tumor vaccine with therapeutic potential shifts tumor-specific T cell response from a type 2 to a type 1 cytokine profile. J Immunol 1998; 161(6): 3033–4lPubMed
34.
go back to reference Inagawa H, Nishizawa T, Honda T, et al. Mechanisms by which chemotherapeutic agents augment the antitumor effects of tumor necrosis factor: involvement of the pattern shift of cytokines from Th.2 to Thl in tumor lesions. Anticancer Res 1998; 18(5D): 3957–64PubMed Inagawa H, Nishizawa T, Honda T, et al. Mechanisms by which chemotherapeutic agents augment the antitumor effects of tumor necrosis factor: involvement of the pattern shift of cytokines from Th.2 to Thl in tumor lesions. Anticancer Res 1998; 18(5D): 3957–64PubMed
35.
go back to reference Hrouda D, Baban B, Dunsmuir WD, et al. Immunotherapy of advanced prostate cancer: a phase I/II trial using Mycobacterium vaccae (SRL 172). Br J Urol 1998; 82(4): 568–73PubMedCrossRef Hrouda D, Baban B, Dunsmuir WD, et al. Immunotherapy of advanced prostate cancer: a phase I/II trial using Mycobacterium vaccae (SRL 172). Br J Urol 1998; 82(4): 568–73PubMedCrossRef
36.
go back to reference Moolten FL. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986; 46(10): 5276–81PubMed Moolten FL. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986; 46(10): 5276–81PubMed
37.
go back to reference Freeman SM, Abboud CN, Whartertby KA, et al. The ‘bystander effect’: tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993; 53(21): 5274–83PubMed Freeman SM, Abboud CN, Whartertby KA, et al. The ‘bystander effect’: tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993; 53(21): 5274–83PubMed
38.
go back to reference Ramesh R, Marrogi AJ, Munshi A, et al. In vivo analysis of the ‘bystander effect’: a cytokine cascade. Exp Hematol 1996; 24(7): 829–38PubMed Ramesh R, Marrogi AJ, Munshi A, et al. In vivo analysis of the ‘bystander effect’: a cytokine cascade. Exp Hematol 1996; 24(7): 829–38PubMed
39.
go back to reference Vile RG, Nelson JA, Castleden S, et al. Systemic gene therapy of murine melanoma using tissue specific expression of the I-ISVtk gene involves an immune component. Cancer Res 1994; 54(23): 6228–34PubMed Vile RG, Nelson JA, Castleden S, et al. Systemic gene therapy of murine melanoma using tissue specific expression of the I-ISVtk gene involves an immune component. Cancer Res 1994; 54(23): 6228–34PubMed
40.
go back to reference Ramesh R, Munshi A, Marrogi AJ, et al. Enhancement of tumor killing using a combination of tumor immunization and HW-tk suicide gene therapy. Int J Cancer 1999; 80(3): 380–6PubMedCrossRef Ramesh R, Munshi A, Marrogi AJ, et al. Enhancement of tumor killing using a combination of tumor immunization and HW-tk suicide gene therapy. Int J Cancer 1999; 80(3): 380–6PubMedCrossRef
41.
go back to reference Klanmanesh AR, Perrin H, Panis Y, et al. A ‘distant’ bystander effect of suicide gene therapy: regression of nontransduced tumors together with a distant transduced tumor. Hum Gene Ther 1997; 8(15): 1807–14CrossRef Klanmanesh AR, Perrin H, Panis Y, et al. A ‘distant’ bystander effect of suicide gene therapy: regression of nontransduced tumors together with a distant transduced tumor. Hum Gene Ther 1997; 8(15): 1807–14CrossRef
42.
go back to reference Moller R, Sun Y, Dorbic T, et al. Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study. Br J Cancer 1998; 77(11): 1907–16PubMedCrossRef Moller R, Sun Y, Dorbic T, et al. Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study. Br J Cancer 1998; 77(11): 1907–16PubMedCrossRef
43.
go back to reference Sun Y, Jurgovsky K, Moller P, et al. Vaccination with IL-12 gene-modified autologous melanoma cells: preclinical results and a first clinical phase 1 study. Gene Ther 1998; 5(4): 481–90PubMedCrossRef Sun Y, Jurgovsky K, Moller P, et al. Vaccination with IL-12 gene-modified autologous melanoma cells: preclinical results and a first clinical phase 1 study. Gene Ther 1998; 5(4): 481–90PubMedCrossRef
44.
go back to reference Dranoff G, Jaffee E, Lazenby A, et al. Vaccination with irradiated turnor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting antitumor immunity. Proc Natl Acad Sci U S A 1993 Apr 15; 90(8): 3539–43PubMedCrossRef Dranoff G, Jaffee E, Lazenby A, et al. Vaccination with irradiated turnor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting antitumor immunity. Proc Natl Acad Sci U S A 1993 Apr 15; 90(8): 3539–43PubMedCrossRef
45.
go back to reference Dranoff G, Soiffer R, Lynch T, et al. Aphase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor. Hum Gene Ther 1997; 8(1): 111–23PubMedCrossRef Dranoff G, Soiffer R, Lynch T, et al. Aphase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor. Hum Gene Ther 1997; 8(1): 111–23PubMedCrossRef
46.
go back to reference Soiffer R, Lynch T, Mihm M, et al. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci U S A 1998 Oct 27; 95(22): 13141–6PubMedCrossRef Soiffer R, Lynch T, Mihm M, et al. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci U S A 1998 Oct 27; 95(22): 13141–6PubMedCrossRef
47.
go back to reference Simons JW, Jaffee EM, Weber CE, et al. Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer. Cancer Res 1997: 57(8): 1537–46PubMed Simons JW, Jaffee EM, Weber CE, et al. Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer. Cancer Res 1997: 57(8): 1537–46PubMed
48.
go back to reference Mackensen A, Veelken H, Lahn M, et al. Induction of tumor-specific cytotoxic T lymphocytes by immunization with autologous tumor cells and interleukin-2 gene transfected fibroblasts. J Mol Med 1997: 75(4): 290–6PubMedCrossRef Mackensen A, Veelken H, Lahn M, et al. Induction of tumor-specific cytotoxic T lymphocytes by immunization with autologous tumor cells and interleukin-2 gene transfected fibroblasts. J Mol Med 1997: 75(4): 290–6PubMedCrossRef
49.
go back to reference Veelken H, Mackensen A, Lahn M, et al. A phase-1 clinical study of autologous tumor cells plus interleukin-2-gene-transfected allogeneic fibroblasts as a vaccine in patients with cancer. Int J Cancer 1997; 70(3): 269–77PubMedCrossRef Veelken H, Mackensen A, Lahn M, et al. A phase-1 clinical study of autologous tumor cells plus interleukin-2-gene-transfected allogeneic fibroblasts as a vaccine in patients with cancer. Int J Cancer 1997; 70(3): 269–77PubMedCrossRef
50.
go back to reference Vieweg J, Rosenthal FM, Bannedi R, et al. Immunotherapy of prostate cancer in the Dunning rat model: use of cytokine gene-modified tumor vaccines. Cancer Res 1994; 54(7): 1760–5PubMed Vieweg J, Rosenthal FM, Bannedi R, et al. Immunotherapy of prostate cancer in the Dunning rat model: use of cytokine gene-modified tumor vaccines. Cancer Res 1994; 54(7): 1760–5PubMed
51.
go back to reference Sanda MG, Ayyagari SR, Jaffee EM, et al. Demonstration of a rational strategy for human prostate cancer gene therapy. J Urol 1994; 151(3): 622–8PubMed Sanda MG, Ayyagari SR, Jaffee EM, et al. Demonstration of a rational strategy for human prostate cancer gene therapy. J Urol 1994; 151(3): 622–8PubMed
52.
go back to reference Peelil DM, Starney TA. Growth responses of normal, benign hyperplastic, and malignant human prostatic epithelial cells in vitro to cholera toxin, pituitary extract, and hydrocortisone. Prostate 1986; 8(1): 51–61CrossRef Peelil DM, Starney TA. Growth responses of normal, benign hyperplastic, and malignant human prostatic epithelial cells in vitro to cholera toxin, pituitary extract, and hydrocortisone. Prostate 1986; 8(1): 51–61CrossRef
53.
go back to reference Huang AY, Golumbek P, Ahmadzadeh M, et al. Role of bone marrow-derived cells in presenting M1IC class 1-restricted tumor antigens. Science 1994; 264(5161): 961–5PubMedCrossRef Huang AY, Golumbek P, Ahmadzadeh M, et al. Role of bone marrow-derived cells in presenting M1IC class 1-restricted tumor antigens. Science 1994; 264(5161): 961–5PubMedCrossRef
54.
go back to reference Knight BC, Souberbielle BE, Rizzardi GP, et al. Allogeneic murine melanoma cell vaccine: a model for the development of human allogeneic cancer vaccine. Melanoma Res 1996; 6(4): 299–306PubMedCrossRef Knight BC, Souberbielle BE, Rizzardi GP, et al. Allogeneic murine melanoma cell vaccine: a model for the development of human allogeneic cancer vaccine. Melanoma Res 1996; 6(4): 299–306PubMedCrossRef
55.
go back to reference Souberbielle BE, Westby M, Gariz S, et al. Comparison of four strategies for tumour vaccination in the B 16-F10 melanoma model. Gene Ther 1998; 5(11): 1447–54PubMedCrossRef Souberbielle BE, Westby M, Gariz S, et al. Comparison of four strategies for tumour vaccination in the B 16-F10 melanoma model. Gene Ther 1998; 5(11): 1447–54PubMedCrossRef
56.
go back to reference Ashley DM, Falola B, Nair S, et al. Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. J Exp Med 1997; 186(7): 1177–82PubMedCrossRef Ashley DM, Falola B, Nair S, et al. Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. J Exp Med 1997; 186(7): 1177–82PubMedCrossRef
57.
go back to reference Lim YS, Kang BY, Kim EJ, et al. Augmentation of therapeutic antiturnor immunity by B 16F10 melanoma cells transfected by interferon-gamma and allogeneic MHC class 1 cDNAs. Mol Cells 1998; 8(5): 629–36PubMed Lim YS, Kang BY, Kim EJ, et al. Augmentation of therapeutic antiturnor immunity by B 16F10 melanoma cells transfected by interferon-gamma and allogeneic MHC class 1 cDNAs. Mol Cells 1998; 8(5): 629–36PubMed
58.
go back to reference Thomas MC, Greten TF, Pardoll DM, et al. Enhanced tumor protection by granulocyte-macrophage colony-stimulating factor expression at the site of an allogeneic vaccine. Hum Gene Ther 1998; 9(6): 835–43PubMedCrossRef Thomas MC, Greten TF, Pardoll DM, et al. Enhanced tumor protection by granulocyte-macrophage colony-stimulating factor expression at the site of an allogeneic vaccine. Hum Gene Ther 1998; 9(6): 835–43PubMedCrossRef
59.
go back to reference Hrouda D, Souberbielle BE, Kayaga J, et al. Mycobacterium vaccae (SRL 172): a potential immunological adjuvant evaluated in rat prostate cancer. Br J Urol 1998; 82(6): 870–6PubMedCrossRef Hrouda D, Souberbielle BE, Kayaga J, et al. Mycobacterium vaccae (SRL 172): a potential immunological adjuvant evaluated in rat prostate cancer. Br J Urol 1998; 82(6): 870–6PubMedCrossRef
Metadata
Title
Prospects for Vaccination in Prostate Cancer
Authors
Matthew J. A. Perry
David Hrouda
Angus G. Dalgleish
Publication date
01-05-2000
Publisher
Springer International Publishing
Published in
Drugs & Aging / Issue 5/2000
Print ISSN: 1170-229X
Electronic ISSN: 1179-1969
DOI
https://doi.org/10.2165/00002512-200016050-00001

Other articles of this Issue 5/2000

Drugs & Aging 5/2000 Go to the issue

Leading Article

Colon Cancer

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.