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Dermatology and Therapy
Published in: Dermatology and Therapy 1/2019

Open Access 01-03-2019 | Review

Propionibacterium (Cutibacterium) acnes Bacteriophage Therapy in Acne: Current Evidence and Future Perspectives

Authors: David E. Castillo, Sonali Nanda, Jonette E. Keri

Published in: Dermatology and Therapy | Issue 1/2019

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Abstract

Acne vulgaris is the most common dermatological disorder worldwide. It is a multifactorial disease that involves increased sebum production, hyperkeratinization of the pilosebaceous unit, Propionibacterium acnes (Cutibacterium acnes) colonization, and inflammation. The human skin microbiome hosts a wide variety of microorganisms, including bacteria, viruses, and fungi. A delicate balance of these microorganisms is essential for the barrier function of the skin. Propionibacterium acnes represents nearly 90% of the human skin microbiome of healthy adults. Acne is a chronic recurrent disease that requires long-lasting treatment, which has led to the emergence of antibiotic resistance. New alternatives to traditional therapy are emerging, including antimicrobial peptides, natural engineered antibodies, and bacteriophages. Bacteriophages have been shown to play a role in human skin health and disease. There is evidence supporting phage therapy in many types of skin infections. P. acnes bacteriophages have been isolated and characterized. However, only a few in vitro studies have tested the ability of bacteriophages to kill P. acnes. Furthermore, there is no evidence on bacteriophage therapy in the treatment of acne in humans. In this review, we summarize the most recent evidence regarding P. acnes bacteriophages and the potential role of these bacteriophages in the treatment of acne. Further research on this field will provide the evidence to use phage therapy to decrease rates of antibiotic resistance and restore antibiotic susceptibility of P. acnes.
Literature
1.
Zaenglein A, Thiboutot D. Acne vulgaris. In: Bolognia J, Schaffer J, Cerroni L, eds. Dermatology. 4th edn. Amsterdam: Elsevier; 2012:588–603.
2.
Hay R, Johns N, Williams H, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. J Investig Dermatol. 2013;134:1527–34.PubMed
3.
Karimkhani C, Dellavalle RP, Coffeng LE, et al. Global skin disease morbidity and mortality: an update from the global burden of disease study 2013. JAMA Dermatol. 2017;153(5):406–12.PubMedPubMedCentral
4.
Lynn DD, Umari T, Dunnick CA, Dellavalle RP. The epidemiology of acne vulgaris in late adolescence. Adolesc Health Med Ther. 2016;7:13–25.PubMedPubMedCentral
5.
Sidbury R, Paller AS. The diagnosis and management of acne. Pediatr Ann. 2000;29(1):17–24.PubMed
6.
White GM. Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J Am Acad Dermatol. 1998;39:S34–7.PubMed
7.
Halvorsen JA, Stern RS, Dalgard F, Thoresen M, Bjertness E, Lien L. Suicidal ideation, mental health problems, and social impairment are increased in adolescents with acne: a population-based study. J Investig Dermatol. 2011;131(2):363–70.PubMed
8.
Liu J, Yan R, Zhong Q, et al. The diversity and host interactions of Propionibacterium acnes bacteriophages on human skin. ISME J. 2015;9(9):2078–93.PubMedPubMedCentral
9.
10.
Coates P, Vyakrnam S, Eady EA, Jones CE, Cove JH, Cunliffe WJ. Prevalence of antibiotic-resistant propionibacteria on the skin of acne patients: 10-year surveillance data and snapshot distribution study. Br J Dermatol. 2002;146(5):840–8.PubMed
11.
Scholz CF, Kilian M. The natural history of cutaneous propionibacteria, and reclassification of selected species within the genus Propionibacterium to the proposed novel genera Acidipropionibacterium gen. nov., Cutibacterium gen. nov. and Pseudopropionibacterium gen. nov. Int J Syst Evol Microbiol. 2016;66(11):4422–32.PubMed
12.
Dessinioti C, Katsambas A. Propionibacterium acnes and antimicrobial resistance in acne. Clin Dermatol. 2017;35(2):163–7.PubMed
13.
Liu PF, Hsieh YD, Lin YC, Two A, Shu CW, Huang CM. Propionibacterium acnes in the pathogenesis and immunotherapy of acne vulgaris. Curr Drug Metab. 2015;16(4):245–54.PubMed
14.
Jonczyk-Matysiak E, Weber-Dabrowska B, Zaczek M, et al. Prospects of phage application in the treatment of acne caused by Propionibacterium acnes. Front Microbiol. 2017;8:164.PubMedPubMedCentral
15.
16.
McGinley KJ, Webster GF, Ruggieri MR, Leyden JJ. Regional variations in density of cutaneous propionibacteria: correlation of Propionibacterium acnes populations with sebaceous secretion. J Clin Microbiol. 1980;12(5):672–5.PubMedPubMedCentral
17.
Brzuszkiewicz E, Weiner J, Wollherr A, et al. Comparative genomics and transcriptomics of Propionibacterium acnes. PLoS One. 2011;6(6):e21581.PubMedPubMedCentral
18.
Kong HH, Segre JA. Skin microbiome: looking back to move forward. J Investig Dermatol. 2012;132(3 Pt 2):933–9.PubMed
19.
Tyner H, Patel R. Propionibacterium acnes biofilm—a sanctuary for Staphylococcus aureus? Anaerobe. 2016;40:63–7.PubMed
20.
Kim J, Ochoa MT, Krutzik SR, et al. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol. 2002;169(3):1535–41.PubMed
21.
Jeremy AH, Holland DB, Roberts SG, Thomson KF, Cunliffe WJ. Inflammatory events are involved in acne lesion initiation. J Investig Dermatol. 2003;121(1):20–7.PubMed
22.
Vowels BR, Yang S, Leyden JJ. Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne. Infect Immun. 1995;63(8):3158–65.PubMedPubMedCentral
23.
Nagy I, Pivarcsi A, Kis K, et al. Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes. Microbes Infect. 2006;8(8):2195–205.PubMed
24.
Kwon H, Suh D. Recent progress in the research about Propionibacterium acnes strain diversity and acne: pathogen or bystander? Int J Dermatol. 2016;55(11):1196–204.PubMed
25.
Jahns A, Lundskog B, Dahlberg I, Tamayo N, McDowell A, Patrick S, et al. No link between rosacea and Propionibacterium acnes. APMIS. 2012;120(11):922–5.PubMed
26.
Fitz-Gibbon S, Tomida S, Chiu BH, et al. Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Investig Dermatol. 2013;133(9):2152–60.PubMed
27.
Lomholt HB, Kilian M. Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne. PLoS One. 2010;5(8):e12277.PubMedPubMedCentral
28.
Lodes MJ, Secrist H, Benson DR, et al. Variable expression of immunoreactive surface proteins of Propionibacterium acnes. Microbiology. 2006;152(Pt 12):3667–81.PubMed
29.
Jassim A, Limoges R. Natural solution to antibiotic resistance: bacteriophages “The Living Drugs”. World J Microbiol Biotechnol. 2014;30:2153–70.PubMedPubMedCentral
30.
Centers for Disease Control and Prevention (CDC). Antibiotic use in the United States, 2017: progress and opportunities. Atlanta: US Department of Health and Human Services; 2017.
31.
Zucca M, Savoia D. The post-antibiotic era: promising developments in the therapy of infectious diseases. Int J Biomed Sci. 2010;6(2):77–86.PubMedPubMedCentral
32.
Clarke T. Drug companies snub antibiotics as pipeline threatens to run dry. Nature. 2003;425:225.PubMed
33.
Sadhasivam S, Sinha M, Saini S, et al. Heterogeneity and antibiotic resistance in Propionibacterium acnes isolates and its therapeutic implications: blurring the lines between commensal and pathogenic phylotypes. Dermatol Ther. 2016;29(6):451–4.PubMed
34.
35.
Mendoza N, Hernandez PO, Tyring SK, Haitz KA, Motta A. Antimicrobial susceptibility of Propionibacterium acnes isolates from acne patients in Colombia. Int J Dermatol. 2013;52(6):688–92.PubMed
36.
Luk N, Hui M, Lee H, et al. Antibiotic-resistant Propionibacterium acnes among acne patients in a regional skin centre in Hong Kong. J Eur Acad Dermatol Venereol. 2013;27(1):31–6.PubMed
37.
Dumont-Wallon G, Moyse D, Blouin E, Dreno B. Bacterial resistance in French acne patients. Int J Dermatol. 2010;49(3):283–8.PubMed
38.
Eady EA, Gloor M, Leyden JJ. Propionibacterium acnes resistance: a worldwide problem. Dermatology. 2003;206(1):54–6.PubMed
39.
Dreno B, Reynaud A, Moyse D, Habert H, Richet H. Erythromycin-resistance of cutaneous bacterial flora in acne. Eur J Dermatol. 2001;11(6):549–53.PubMed
40.
Ross JI, Snelling AM, Carnegie E, et al. Antibiotic-resistant acne: lessons from Europe. Br J Dermatol. 2003;148(3):467–78.PubMed
41.
Tan HH, Tan AW, Barkham T, Yan XY, Zhu M. Community-based study of acne vulgaris in adolescents in Singapore. Br J Dermatol. 2007;157(3):547–51.PubMed
42.
Kurokawa I, Nishijima S, Kawabata S. Antimicrobial susceptibility of Propionibacterium acnes isolated from acne vulgaris. Eur J Dermatol. 1999;9(1):25–8.PubMed
43.
Nishijima S, Kurokawa I, Katoh N, Watanabe K. The bacteriology of acne vulgaris and antimicrobial susceptibility of Propionibacterium acnes and Staphylococcus epidermidis isolated from acne lesions. J Dermatol. 2000;27(5):318–23.PubMed
44.
Burkhart C, Burkhart C. Microbiology’s principle of biofilms as a major factor in the pathogenesis of acne vulgaris. Int J Dermatol. 2003;42:925–7.PubMed
45.
Levy R, Huang E, Roling D, Leyden J, Margolis D. Effect of antibiotics on the oropharyngeal flora in patients with acne. Arch Dermatol. 2003;139:467–71.PubMed
46.
Mills O Jr, Thornsberry C, Cardin CW, Smiles KA, Leyden JJ. Bacterial resistance and therapeutic outcome following three months of topical acne therapy with 2% erythromycin gel versus its vehicle. Acta Derm Venereol. 2002;82(4):260–5.PubMed
47.
Thiboutot D, Gollnick H, Bettoli V, et al. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J Am Acad Dermatol. 2009;60:1–50.
48.
Grice EA. The skin microbiome: potential for novel diagnostic and therapeutic approaches to cutaneous disease. Semin Cutan Med Surg. 2014;33(2):98–103.PubMedPubMedCentral
49.
Oh J, Conlan S, Polley EC, Segre JA, Kong HH. Shifts in human skin and nares microbiota of healthy children and adults. Genome Med. 2012;4(10):77.PubMedPubMedCentral
50.
51.
Lin L, Hong W, Ji X, Han J, Huang L, Wei Y. Isolation and characterization of an extremely long tail Thermus bacteriophage from Tengchong hot springs in China. J Basic Microbiol. 2010;50(5):452–6.PubMed
52.
Prigent M, Leroy M, Confalonieri F, Dutertre M, DuBow M. A diversity of bacteriophage forms and genomes can be isolated from the surface sands of the Sahara Desert. Extremophiles. 2005;9(4):289–96.PubMed
53.
Wittebole X, De Roock S, Opal S. A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens. Virulence. 2014;5(1):226–35.PubMed
54.
55.
Abedon S. Phages. In: Hyman P, Abedon S, eds. Bacteriophages in health and disease. AMCM 24 advances in molecular and cellular microbiology. Wallingford:CABI; 2012. Retrieved from https://​ebookcentral.​proquest.​com. Accessed 7 July 2018.
56.
O’Shea YA, Boyd EF. Mobilization of the Vibrio pathogenicity island between Vibrio cholerae isolates mediated by CP-T1 generalized transduction. FEMS Microbiol Lett. 2002;214(2):153–7.PubMed
57.
Maiques E, Ubeda C, Tormo MA, et al. Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer. J Bacteriol. 2007;189(15):5608–16.PubMedPubMedCentral
58.
Edgar R, Friedman N, Molshanski-Mor S, Qimron U. Reversing bacterial resistance to antibiotics by phage-mediated delivery of dominant sensitive genes. Appl Environ Microbiol. 2012;78(3):744–51.PubMedPubMedCentral
59.
Lu T, Collins J. Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy. Proc Natl Acad Sci USA. 2009;106(12):4629–34.PubMedPubMedCentral
60.
Brzin B. Studies on the Corynebacterium acnes. Acta Pathol Microbiol Scand. 1964;60:599–608.PubMed
61.
Zierdt C, Webster C, Rude W. Study of the anaerobic corynebacteria. Int J Syst Evol Microbiol. 1968;18(1):33–47.
62.
Webster G, Cummins C. Use of bacteriophage typing to distinguish Propionibacterium acne types I and II. J Clin Microbiol. 1978;7(1):84–90.PubMedPubMedCentral
63.
64.
Whiteside JA, Voss JG. Incidence and lipolytic activity of Propionibacterium acnes (Corynebacterium acnes group I) and P. granulosum (C. acnes group II) in acne and in normal skin. J Investig Dermatol. 1973;60(2):94–7.PubMed
65.
Marples RR, Leyden JJ, Stewart RN, Mills OH Jr, Kligman AM. The skin microflora in acne vulgaris. J Investig Dermatol. 1974;62(1):37–41.PubMed
66.
Marples RR, McGinley KJ, Mills OH. Microbiology of comedones in acne vulgaris. J Investig Dermatol. 1973;60(2):80–3.PubMed
67.
Puhvel SM, Amirian DA. Bacterial flora of comedones. Br J Dermatol. 1979;101(5):543–8.PubMed
68.
Willner D, Furlan M, Schmieder R, et al. Metagenomic detection of phage-encoded platelet-binding factors in the human oral cavity. Proc Natl Acad Sci USA. 2011;108(Suppl 1):4547–53.PubMed
69.
Sharon I, Morowitz MJ, Thomas BC, Costello EK, Relman DA, Banfield JF. Time series community genomics analysis reveals rapid shifts in bacterial species, strains, and phage during infant gut colonization. Genome Res. 2013;23(1):111–20.PubMedPubMedCentral
70.
Farrar MD, Howson KM, Bojar RA, et al. Genome sequence and analysis of a Propionibacterium acnes bacteriophage. J Bacteriol. 2007;189(11):4161–7.PubMedPubMedCentral
71.
Lood R, Collin M. Characterization and genome sequencing of two Propionibacterium acnes phages displaying pseudolysogeny. BMC Genom. 2011;12:198.
72.
Brown TL, Petrovski S, Dyson ZA, Seviour R, Tucci J. The formulation of bacteriophage in a semi solid preparation for control of Propionibacterium acnes growth. PLoS One. 2016;11(3):e0151184.PubMedPubMedCentral
73.
Lood R, Morgelin M, Holmberg A, Rasmussen M, Collin M. Inducible siphoviruses in superficial and deep tissue isolates of Propionibacterium acnes. BMC Microbiol. 2008;8:139.PubMedPubMedCentral
74.
Zierdt CH. Properties of Corynebacterium acnes bacteriophage and description of an interference phenomenon. J Virol. 1974;14(5):1268–73.PubMedPubMedCentral
75.
Bruttin A, Brussow H. Human volunteers receiving Escherichia coli phage T4 orally: a safety test of phage therapy. Antimicrob Agents Chemother. 2005;49(7):2874–8.PubMedPubMedCentral
76.
Kutter E, De Vos D, Gvasalia G, et al. Phage therapy in clinical practice: treatment of human infections. Curr Pharm Biotechnol. 2010;11(1):69–86.PubMed
77.
Rhoads DD, Wolcott RD, Kuskowski MA, Wolcott BM, Ward LS, Sulakvelidze A. Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial. J Wound Care. 2009;18(6):237–8, 240–3.PubMed
78.
Wright A, Hawkins C, Anggård E, Harper D. A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy. Clin Otolaryngol. 2009;34(4):349–57.PubMed
79.
Neely K, Albright B, Zurowski M, Davis M. Development of bacteriophage therapy for the skin disease acne. In: The 108th General Meeting of the American Society for Microbiology. Boston; 2008.
80.
O’Flaherty S, Ross R, Meaney W, Fitzgerald G, Elbreki M, Coffey A. Potential of the polyvalent anti-Staphylococcus bacteriophage K for control of antibiotic-resistant staphylococci fromhospitals. Appl Environ Microbiol. 2005;71:1836–42.PubMedPubMedCentral
81.
Schmelcher M, Donovan D, Loessner M. Bacteriophage endolysins as novel antimicrobials. Future Microbiol. 2012;7(10):1147–71.PubMed
82.
Nelson D, Schmelcher M, Rodriguez-Rubio L, et al. Endolysins as antimicrobials. Adv Virus Res. 2012;83:299.PubMed
83.
84.
Matsuzaki S, Yasuda M, Nishikawa H, et al. Experimental protection of mice against lethal Staphylococcus aureus infection by novel bacteriophage phi MR11. J Infect Dis. 2003;187(4):613–24.PubMed
85.
Biswas B, Adhya S, Washart P, et al. Bacteriophage therapy rescues mice bacteremic from a clinical isolate of vancomycin-resistant Enterococcus faecium. Infect Immun. 2002;70(1):204–10.PubMedPubMedCentral
86.
Vinodkumar CS, Neelagund YF, Kalsurmath S. Bacteriophage in the treatment of experimental septicemic mice from a clinical isolate of multidrug resistant Klebsiella pneumoniae. J Commun Dis. 2005;37(1):18–29.PubMed
87.
Wang J, Hu B, Xu M, et al. Use of bacteriophage in the treatment of experimental animal bacteremia from imipenem-resistant Pseudomonas aeruginosa. Int J Mol Med. 2006;17:309–17.PubMed
88.
Wang J, Hu B, Xu M, et al. Therapeutic effectiveness of bacteriophages in the rescue of mice with extended spectrum beta-lactamase-producing Escherichia coli bacteremia. Int J Mol Med. 2006;17(2):347–55.PubMed
89.
Chibani-Chennoufi S, Sidoti J, Bruttin A, Kutter E, Sarker S, Brussow H. In vitro and in vivo bacteriolytic activities of Escherichia coli phages: implications for phage therapy. Antimicrob Agents Chemother. 2004;48(7):2558–69.PubMedPubMedCentral
90.
Merabishvili M, De Vos D, Verbeken G, et al. Selection and characterization of a candidate therapeutic bacteriophage that lyses the Escherichia coli O104:H4 strain from the 2011 outbreak in Germany. PLoS One. 2012;7:e52709.PubMedPubMedCentral
91.
Pouillot F, Chomton M, Blois H, et al. Efficacy of bacteriophage therapy in experimental sepsis and meningitis caused by a clone O25b:H4-ST131 Escherichia coli strain producing CTX-M-15. Antimicrob Agents Chemother. 2012;56(7):3568–75.PubMedPubMedCentral
92.
Chhibber S, Kaur T, Sandeep K. Co-therapy using lytic bacteriophage and linezolid: effective treatment in eliminating methicillin resistant Staphylococcus aureus (MRSA) from diabetic foot infections. PLoS One. 2013;8(2):e56022.PubMedPubMedCentral
93.
Golkar Z, Bagasra O, Pace DG. Bacteriophage therapy: a potential solution for the antibiotic resistance crisis. J Infect Dev Ctries. 2014;8(2):129–36.PubMed
94.
Sarker SA, McCallin S, Barretto C, et al. Oral T4-like phage cocktail application to healthy adult volunteers from Bangladesh. Virology. 2012;434(2):222–32.PubMed
95.
Gorski A, Miedzybrodzki R, Borysowski J, et al. Bacteriophage therapy for the treatment of infections. Curr Opin Investig Drugs. 2009;10(8):766–74.PubMed
96.
Azeredo J, Sutherland I. The use of phages for the removal of infectious biofilm. Curr Pharm Biotechnol. 2008;9:261–6.PubMed
97.
Alemayehu D, Casey P, McAuliffe O, et al. Bacteriophages ϕMR299-2 and ϕNH-4 can eliminate Pseudomonas aeruginosa in the murine lung and on cystic fibrosis lung airway cells. mBio. 2012;3(2):e00029.PubMedPubMedCentral
98.
Alves DR, Perez-Esteban P, Kot W, et al. A novel bacteriophage cocktail reduces and disperses Pseudomonas aeruginosa biofilms under static and flow conditions. Microb Biotechnol. 2016;9(1):61–74.PubMed
99.
Curtin J, Donlanm R. Using bacteriophages to reduce formation of catheter-associated biofilms by Staphylococcus epidermidis. Antimicrob Agents Chemother. 2006;50(4):1268–75.PubMedPubMedCentral
100.
Fong SA, Drilling A, Morales S, et al. Activity of bacteriophages in removing biofilms of Pseudomonas aeruginosa isolates from chronic rhinosinusitis patients. Front Cell Infect Microbiol. 2017;7:418.PubMedPubMedCentral
101.
Lehman SM, Donlan RM. Bacteriophage-mediated control of a two-species biofilm formed by microorganisms causing catheter-associated urinary tract infections in an in vitro urinary catheter model. Antimicrob Agents Chemother. 2015;59(2):1127–37.PubMedPubMedCentral
102.
Comeau AM, Tétart F, Trojet S, Prère M, Krisch H. Phage–antibiotic synergy (PAS): blactam and quinolone antibiotics stimulate virulent phage growth. PLoS One. 2007;2:e799.PubMedPubMedCentral
103.
Coulter LB, McLean RJ, Rohde RE, Aron GM. Effect of bacteriophage infection in combination with tobramycin on the emergence of resistance in Escherichia coli and Pseudomonas aeruginosa biofilms. Viruses. 2014;6(10):3778–86.PubMedPubMedCentral
104.
Hagens S, Habel A, Blasi U. Augmentation of the antimicrobial efficacy of antibiotics by filamentous phage. Microbial Drug Resist (Larchmt, NY). 2006;12(3):164–8.
105.
Kamal F, Dennis JJ. Burkholderia cepacia complex phage-antibiotic synergy (PAS): antibiotics stimulate lytic phage activity. Appl Environ Microbiol. 2015;81(3):1132–8.PubMedPubMedCentral
106.
Kirby AE. Synergistic action of gentamicin and bacteriophage in a continuous culture population of Staphylococcus aureus. PLoS One. 2012;7(11):e51017.PubMedPubMedCentral
107.
Knezevic P, Curcin S, Aleksic V, Petrusic M, Vlaski L. Phage-antibiotic synergism: a possible approach to combatting Pseudomonas aeruginosa. Res Microbiol. 2013;164(1):55–60.PubMed
108.
Torres-Barcelo C, Arias-Sanchez FI, Vasse M, Ramsayer J, Kaltz O, Hochberg ME. A window of opportunity to control the bacterial pathogen Pseudomonas aeruginosa combining antibiotics and phages. PLoS One. 2014;9(9):e106628.PubMedPubMedCentral
109.
Torres-Barceló C, Hochberg M. Evolutionary rationale for phages as complements of antibiotics. Trends Microbiol. 2016;24(4):249–56.PubMed
110.
Verma V, Harjai K, Chhibber S. Restricting ciprofloxacin-induced resistant variant formation in biofilm of Klebsiella pneumoniae B5055 by complementary bacteriophage treatment. J Antimicrob Chemother. 2009;64(6):1212–8.PubMed
111.
Zhang QG, Buckling A. Phages limit the evolution of bacterial antibiotic resistance in experimental microcosms. Evol Appl. 2012;5(6):575–82.PubMedPubMedCentral
112.
Miedzybrodzki R, Fortuna W, Weber-Dabrowska B, Górski A. Phage therapy of staphylococcal infections (including MRSA) may be less expensive than antibiotic treatment. Postepy Hig Med Dosw. 2007;3:461–5.
113.
Denou E, Bruttin A, Barretto C, Ngom-Bru C, Brussow H, Zuber S. T4 phages against Escherichia coli diarrhea: potential and problems. Virology. 2009;388(1):21–30.PubMed
114.
Miedzybrodzki R, Borysowski J, Weber-Dabrowska B, et al. Clinical aspects of phage therapy. Adv Virus Res. 2012;83:73–121.PubMed
115.
Lin DM, Koskella B, Lin HC. Phage therapy: an alternative to antibiotics in the age of multi-drug resistance. World J Gastrointest Pharmacol Ther. 2017;8(3):162–73.PubMedPubMedCentral
116.
Drulis-Kawa Z, Majkowska-Skrobek G, Maciejewska B, Delattre AS, Lavigne R. Learning from bacteriophages—advantages and limitations of phage and phage-encoded protein applications. Curr Protein Pept Sci. 2012;13(8):699–722.PubMedPubMedCentral
Metadata
Title
Propionibacterium (Cutibacterium) acnes Bacteriophage Therapy in Acne: Current Evidence and Future Perspectives
Authors
David E. Castillo
Sonali Nanda
Jonette E. Keri
Publication date
01-03-2019
Publisher
Springer Healthcare
Published in
Dermatology and Therapy / Issue 1/2019
Print ISSN: 2193-8210
Electronic ISSN: 2190-9172
DOI
https://doi.org/10.1007/s13555-018-0275-9

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