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Pediatric Nephrology
Published in: Pediatric Nephrology 2/2017

01-02-2017 | Review

Pronephric tubule formation in zebrafish: morphogenesis and migration

Authors: Richard W. Naylor, Alan J. Davidson

Published in: Pediatric Nephrology | Issue 2/2017

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Abstract

The nephron is the functional subunit of the vertebrate kidney and plays important osmoregulatory and excretory roles during embryonic development and in adulthood. Despite its central role in kidney function, surprisingly little is known about the molecular and cellular processes that control nephrogenesis. The zebrafish pronephric kidney, comprising two nephrons, provides a visually accessible and genetically tractable model system for a better understanding of nephron formation. Using this system, various developmental processes, including the commitment of mesoderm to a kidney fate, renal tubule proliferation, and migration, can be studied during nephrogenesis. Here, we discuss some of these processes in zebrafish with a focus on the pathways that influence renal tubule cell morphogenesis.
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Metadata
Title
Pronephric tubule formation in zebrafish: morphogenesis and migration
Authors
Richard W. Naylor
Alan J. Davidson
Publication date
01-02-2017
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 2/2017
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-016-3353-1

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