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01-02-2009 | Correspondence

Prolonging resuscitation and postponing the death of activated protein C or is it?

Authors: Kaggere Shivalingaiah Paramesh, Jim Zwaal

Published in: Intensive Care Medicine | Issue 2/2009

Excerpt

The November issue of Intensive Care Medicine features three separate editorials [1‐3] and one special article [4] about the design of a new trial investigating activated protein C (APC). This trial is done at the behest of EMEA (the European drug agency) as a requirement for further licensing of APC in Europe. …

Mancebo J, Antonelli M (2008) Editors’ comments on a new trial of activated protein C for persistent septic shock. Intensive Care Med 34:1948–1949PubMedCrossRef

Suter PM, Takala J (2008) Science, medicine and industry: are we getting out of the black hole in sepsis research? Intensive Care Med 34:1950–1954PubMedCrossRef

Sweeney DA, Danner RL, Eichacker PQ, Natanson C (2008) Once is not enough: clinical trials in sepsis. Intensive Care Med 34:1955–1960PubMedCrossRef

Finfer S, Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Gardlund B, Marshall JC, Rhodes A (2008) Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med 34:1935–1947PubMedCrossRef

Title: Prolonging resuscitation and postponing the death of activated protein C or is it?
Authors: Kaggere Shivalingaiah Paramesh
Jim Zwaal
Publication date: 01-02-2009
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 2/2009
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1389-9

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Prolonging resuscitation and postponing the death of activated protein C or is it?

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

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