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28-05-2022 | Progressive Supranuclear Palsy | Original Article

Episodic memory in progressive supranuclear palsy: a neuropsychological and neuroimaging study

Authors: Arthur Cassa Macedo, Paulo Caramelli, Elisa de Paula França Resende, Luciano Inácio Mariano, Vítor Tumas, Antônio Lúcio Teixeira, Sarah Teixeira Camargos, Francisco Eduardo Costa Cardoso, Leonardo Cruz de Souza

Published in: Neurological Sciences | Issue 9/2022

Abstract

Background

Episodic memory impairment may occur in progressive supranuclear palsy (PSP). However, it remains uncertain whether this is due to executive dysfunction or to the involvement of brain areas responsible for memory.

Objectives

To investigate the specific brain regions underlying episodic memory impairment in PSP.

Methods

Twenty-one patients with PSP and 20 healthy controls underwent the Figure Memory Test (FMT) from the Brief Cognitive Screening Battery and brain MRI. We explored correlations between gray matter volumes and memory scores in PSP patients, adjusting for age and performance on the Frontal Assessment Battery.

Results

PSP patients performed worse than controls (p < 0.001) on delayed recall in the FMT. Delayed recall scores correlated to bilateral hippocampal and parahippocampal volumes in PSP patients.

Conclusions

Medial temporal structures may play a role in episodic memory impairment in PSP, suggesting that amnesia in PSP is not solely due to executive dysfunction.

Respondek G et al (2014) The phenotypic spectrum of progressive supranuclear palsy: a retrospective multicenter study of 100 definite cases. Mov Disord 29(14):1758–1766CrossRef

Höglinger GU et al (2017) Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord 32(6):853–864CrossRef

Albert ML, Feldman RG, Willis AL (1974) The “subcortical dementia” of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry 37(2):121–130CrossRef

Dubois B et al (1988) Slowing of cognitive processing in progressive supranuclear palsy: A comparison with Parkinson’s disease. Arch Neurol 45(11):1194–1199CrossRef

Litvan I et al (1989) Memory impairment in patients with progressive supranuclear palsy. Arch Neurol 46(7):765–767CrossRef

Maher E, Smith EM, Lees A (1985) Cognitive deficits in the Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). J Neurol Neurosurg Psychiatry 48(12):1234–1239CrossRef

Milberg WM, Albert (1989) Cognitive differences between patients with progressive supranuclear palsy and Alzheimer’s disease. J Clin Exp Neuropsychol 11(5):605–614CrossRef

Pillon B et al (1986) Heterogeneity of cognitive impairment in progressive supranuclear palsy, Parkinson’s disease, and Alzheimer’s disease. Neurology 36(9):1179–1179CrossRef

Robbins TW et al (1994) Cognitive deficits in progressive supranuclear palsy, Parkinson’s disease, and multiple system atrophy in tests sensitive to frontal lobe dysfunction. J Neurol, Neurosurg Psychiatry. 57(1):79–88CrossRef

10.

Macedo AC et al (2022) Do Patients with Progressive Supranuclear Palsy Have Episodic Memory Impairment? A Systematic Review. Movement Disorders Clin Pract 9(4):436–445CrossRef

11.

Bak TH et al (2010) Behavioural symptoms in progressive supranuclear palsy and frontotemporal dementia. J Neurol Neurosurg Psychiatry 81(9):1057–1059CrossRef

12.

Brown RG et al (2010) Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy. Brain 133(8):2382–2393CrossRef

13.

Ramanan S et al (2019) Fronto-parietal contributions to episodic retrieval—evidence from neurodegenerative disorders. Learn Mem 26(7):262–271CrossRef

14.

Tsai RM et al (2016) Clinical correlates of longitudinal brain atrophy in progressive supranuclear palsy. Parkinsonism Relat Disord 28:29–35CrossRef

15.

Yoo HS et al (2018) The role of 18F-FP-CIT PET in differentiation of progressive supranuclear palsy and frontotemporal dementia in the early stage. Eur J Nucl Med Mol Imaging 45(9):1585–1595CrossRef

16.

Brucki SM et al (2003) Suggestions for utilization of the mini-mental state examination in Brazil. Arq Neuropsiquiatr 61(3B):777–781CrossRef

17.

Beato R et al (2012) Frontal assessment battery in a Brazilian sample of healthy controls: normative data. Arq Neuropsiquiatr 70(4):278–280CrossRef

18.

Machado TH et al (2009) Normative data for healthy elderly on the phonemic verbal fluency task - FAS. Dement Neuropsychol 3(1):55–60CrossRef

19.

Nitrini R et al (2004) Performance of illiterate and literate nondemented elderly subjects in two tests of long-term memory. J Int Neuropsychol Soc 10(4):634–638CrossRef

20.

Nitrini R et al (2021) The Figure Memory Test: diagnosis of memory impairment in populations with heterogeneous educational background. Dement Neuropsychol 15(2):173–185CrossRef

21.

Castro S et al (2009) The abbreviated form of the Brief Cognitive Battery in the diagnosis of dementia in Alzheimer’s disease. Dement Neuropsychol. 3:4CrossRef

22.

Smith SM et al (2004) Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23(Suppl 1):S208–S219CrossRef

23.

Jenkinson M et al (2012) Fsl Neuroimage 62(2):782–790CrossRef

24.

Yarkoni T et al (2011) Large-scale automated synthesis of human functional neuroimaging data. Nat Methods 8(8):665–670CrossRef

25.

Resende PF et al (2021) Different patterns of gray matter atrophy in behavioral variant frontotemporal dementia with and without episodic memory impairment. Int J Geriatr Psychiatry

26.

Goncalves SAB et al (2020) Apathy in frontotemporal dementia is related to medial prefrontal atrophy and is independent of executive dysfunction. Brain Res 1737:146799CrossRef

27.

Yew B et al (2013) Lost and forgotten? Orientation versus memory in Alzheimer’s disease and frontotemporal dementia. J Alzheimers Dis 33(2):473–481CrossRef

28.

Yassuda MS et al (2017) Normative data for the Brief Cognitive Screening Battery stratified by age and education. Dement Neuropsychol 11(1):48–53CrossRef

29.

Sitek EJ et al (2017) The pattern of verbal, visuospatial and procedural learning in Richardson variant of progressive supranuclear palsy in comparison to Parkinson’s disease. Psychiatr Pol 51(4):647–659CrossRef

30.

Toller G et al (2018) Individual differences in socioemotional sensitivity are an index of salience network function. Cortex 103:211–223CrossRef

31.

Wagshal D et al (2015) Divergent CSF τ alterations in two common tauopathies: Alzheimer’s disease and progressive supranuclear palsy. J Neurol Neurosurg Psychiatry 86(3):244–250CrossRef

32.

Ramanan S et al (2017) Determinants of theory of mind performance in Alzheimer’s disease: A data-mining study. Cortex 7(88):8–18CrossRef

33.

Pillon B et al (1993) Explicit memory in Alzheimer’s, Huntington’s, and Parkinson’s diseases. Arch Neurol 50(4):374–379CrossRef

34.

Burton CL et al (2009) Functional abilities in older adults with mild cognitive impairment. Gerontology 55(5):570–581CrossRef

35.

Schmitter-Edgecombe M, Woo E, Greeley DR (2009) Characterizing multiple memory deficits and their relation to everyday functioning in individuals with mild cognitive impairment. Neuropsychology 23(2):168CrossRef

36.

Jecmenica Lukic M et al (2020) Copathology in Progressive Supranuclear Palsy: Does It Matter? Mov Disord 35(6):984–993CrossRef

Title: Episodic memory in progressive supranuclear palsy: a neuropsychological and neuroimaging study
Authors: Arthur Cassa Macedo
Paulo Caramelli
Elisa de Paula França Resende
Luciano Inácio Mariano
Vítor Tumas
Antônio Lúcio Teixeira
Sarah Teixeira Camargos
Francisco Eduardo Costa Cardoso
Leonardo Cruz de Souza
Publication date: 28-05-2022
Publisher: Springer International Publishing
Keyword: Progressive Supranuclear Palsy
Published in: Neurological Sciences / Issue 9/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-06160-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Episodic memory in progressive supranuclear palsy: a neuropsychological and neuroimaging study

Abstract

Background

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objectives

Methods

Results

Conclusions

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