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Open Access 01-02-2018 | Case Report

Progressive multifocal leukoencephalopathy in the absence of immunosuppression

Authors: Benjamin E. Zucker, Sybil R. L. Stacpoole

Published in: Journal of NeuroVirology | Issue 1/2018

Abstract

A 69-year-old woman presented with a cortical hand syndrome progressing over several weeks. MRI brain showed characteristic appearances of progressive multifocal leukoencephalopathy (PML), confirmed by detection of the JC virus in CSF, despite the absence of any evidence of immunosuppression. Treatment with mirtazapine, mefloquine and cidofovir did not affect the progression of the disease, which was fatal within 7 months of presentation. This report adds to the small case literature that suggests that PML can occur in immunocompetent people, albeit extremely rarely.

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Title: Progressive multifocal leukoencephalopathy in the absence of immunosuppression
Authors: Benjamin E. Zucker
Sybil R. L. Stacpoole
Publication date: 01-02-2018
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 1/2018
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-017-0592-2

At a glance: The STEP trials

Springer Medicine

Progressive multifocal leukoencephalopathy in the absence of immunosuppression

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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