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Open Access 01-12-2010 | Case report

Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report

Authors: Halvor Naess, Solveig Glad, Anette Storstein, Christine H Rinaldo, Sverre J Mørk, Kjell-Morten Myhr, Hans Hirsch

Published in: BMC Neurology | Issue 1/2010

Abstract

Background

To report the clinical course of PML in an apparently immunocompetent patient treated with cidofovir.

Case Presentation

A 35-year-old immunocompetent man who developed progressive hemianopsia, aphasia, and limb weakness underwent repeated MRI scans of the brain, spinal fluid analyses, and brain biopsy. Before diagnosis was established based on brain biopsy, he was consecutively treated with methylprednisolone, acyclovir, ceftriaxone and plasmapheresis, but he deteriorated rapidly suggestive of the immune reconstitution inflammatory syndrome (IRIS). He started to recover two weeks after the initiation of treatment with cidofovir and has had no relapse at 3 1/2 years of follow-up. MRI has shown marked improvement.

Conclusions

PML should be considered in immunocompetent patients with a typical clinical course and MRI findings compatible with PML. Treatment with cidofovir should be considered as early as possible in the disease course.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2377/10/32/prepub

Title: Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report
Authors: Halvor Naess
Solveig Glad
Anette Storstein
Christine H Rinaldo
Sverre J Mørk
Kjell-Morten Myhr
Hans Hirsch
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2010
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/1471-2377-10-32

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report

Abstract

Background

Case Presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case Presentation

Conclusions

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