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BMC Neurology
Published in: BMC Neurology 1/2013

Open Access 01-12-2013 | Case report

Progression of logopenic variant primary progressive aphasia to apraxia and semantic memory deficits

Authors: Michitaka Funayama, Yoshitaka Nakagawa, Yoko Yamaya, Fumihiro Yoshino, Masaru Mimura, Motoichiro Kato

Published in: BMC Neurology | Issue 1/2013

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Abstract

Background

Due to the nature of neurodegenerative disorders, patients with primary progressive aphasia develop cognitive impairment other than aphasia as the disorder progresses. The progression of logopenic variant primary progressive aphasia (lvPPA), however, has not been well described. In particular, praxic disorders and semantic memory deficits have rarely been reported.

Case presentations

We report three patients in the initial stage of lvPPA who subsequently developed apraxia in the middle stage and developed clinically evident semantic memory deficits in the advanced stages.

Conclusions

The present case series suggests that some patients with lvPPA develop an atypical type of dementia with apraxia and semantic memory deficits, suggesting that these cases should be classified as a type of early-onset Alzheimer’s disease.
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Metadata
Title
Progression of logopenic variant primary progressive aphasia to apraxia and semantic memory deficits
Authors
Michitaka Funayama
Yoshitaka Nakagawa
Yoko Yamaya
Fumihiro Yoshino
Masaru Mimura
Motoichiro Kato
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2013
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-13-158

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