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Open Access 01-12-2023 | Review

Progress in the study of parvovirus entry pathway

Authors: Jiuming Shi, Yifeng Pei, Qian Yu, Hao dong

Published in: Virology Journal | Issue 1/2023

Abstract

A group of DNA viruses called parvoviruses that have significant effects on cancer therapy and genetic engineering applications. After passing through the cell membrane to reach the cytosol, it moves along the microtubule toward the nuclear membrane. The nuclear localization signal (NLS) is recognized by importin-beta (impβ) and other proteins from the complex outside the nuclear membrane and binds to enter the nucleus via the nuclear pore complex (NPC). There are two main pathways for viruses to enter the nucleus. The classical pathway is through the interaction of imp α and impβ with NLS via NPC. The other is the NPC mediated by the combination of impβ and it. While the capsid is introduced into the nucleus through classical nuclear transduction, there is also a transient nuclear membrane dissolution leading to passive transport into the nucleus, which has been proposed in recent years. This article mainly discusses several nuclear entry pathways and related proteins, providing a reference for subsequent research on viral entry pathways.

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Title: Progress in the study of parvovirus entry pathway
Authors: Jiuming Shi
Yifeng Pei
Qian Yu
Hao dong
Publication date: 01-12-2023
Publisher: BioMed Central
Published in: Virology Journal / Issue 1/2023
Electronic ISSN: 1743-422X
DOI: https://doi.org/10.1186/s12985-023-02016-z

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