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World Journal of Surgery
Published in: World Journal of Surgery 8/2016

01-08-2016 | Original Scientific Report

Prognostic Value of the Number of Retrieved Lymph Nodes in Pathological Nx or N0 Classical Papillary Thyroid Carcinoma

Authors: Tae-Yon Sung, Jong Ho Yoon, Dong Eun Song, Yu-mi Lee, Tae-Yong Kim, Ki-Wook Chung, Won Bae Kim, Young Kee Shong, Suck Joon Hong

Published in: World Journal of Surgery | Issue 8/2016

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Abstract

Background

This study evaluated the clinical implications of the number of retrieved central lymph nodes (LN) for the recurrence and recurrence-free survival (RFS) outcomes in patients with pathological Nx (pNx) or N0 classical papillary thyroid carcinoma (PTC).

Methods

In total, 464 patients were enrolled following total thyroidectomy with central LN dissection. The risk factors related to recurrence and RFS were evaluated and compared between these groups.

Results

Age, primary tumor size, and number of retrieved central LNs were independent risk factors for recurrence according to multivariate analysis (p < 0.05). The cut-off value for the number of retrieved central LNs related to recurrence was 4.5. Group 2 (pN0; ≥5 nodes) demonstrated a significantly higher proportion of patients with an ablation-stimulated thyroglobulin (sTg) level <2.0 ng/mL (84.9 vs 61.1 %; p < 0.050) and control sTg level <1.0 ng/mL (92.1 vs 79.6 %; p < 0.050) in comparison with patients in group 1 (pNx or pN0; 1–4 nodes). Perioperative complication rates were comparable between groups.

Conclusion

The number of retrieved central LNs is an independent risk factor for recurrence, even among patients with pNx or pN0 classical PTC. A thorough central LN dissection may therefore improve the long-term RFS rate.
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Metadata
Title
Prognostic Value of the Number of Retrieved Lymph Nodes in Pathological Nx or N0 Classical Papillary Thyroid Carcinoma
Authors
Tae-Yon Sung
Jong Ho Yoon
Dong Eun Song
Yu-mi Lee
Tae-Yong Kim
Ki-Wook Chung
Won Bae Kim
Young Kee Shong
Suck Joon Hong
Publication date
01-08-2016
Publisher
Springer International Publishing
Published in
World Journal of Surgery / Issue 8/2016
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-016-3490-5

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