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World Journal of Surgery
Published in: World Journal of Surgery 8/2013

01-08-2013

Influence of Prophylactic Neck Dissection on Rate of Retreatment for Papillary Thyroid Carcinoma

Authors: Dana M. Hartl, Elisabeth Mamelle, Isabelle Borget, Sophie Leboulleux, Haïtham Mirghani, Martin Schlumberger

Published in: World Journal of Surgery | Issue 8/2013

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Abstract

Background

Prophylactic neck dissection (PND) for papillary thyroid cancer is controversial. The objective of this study was to analyze the influence of PND on the rate of retreatment.

Methods

In this retrospective case-control study, papillary thyroid carcinomas >10 mm without ultrasonographic evidence of nodal disease (cN0) were treated with total thyroidectomy (TT) or TT with bilateral central compartment PND. All received postoperative radioactive iodine (131I) and were followed for at least 1 year. We compared the rate of retreatment (surgery or 131I).

Results

Altogether, 246 patients (mean age 46 years, 78 % women) underwent TT (n = 91) or TT + PND (n = 155). The groups were similar in age, sex, tumor size, and follow-up (median 6.3 years) (p > 0.05). Overall, 11 (12 %) of the patients in the TT group underwent reoperation in the central compartment for recurrence versus 3 (2 %) in the TT + PND group (p < 0.001). There were 1.18 administrations of 131I for the TT group versus 1.08 for the TT + PND group (p = 0.08). The average cumulative dose of 131I was 3.9 ± 1.8 GBq for the TT group and 3.8 ± 1.3 GBq for the TT + PND group (p = 0.52). Actuarial (Kaplan-Meier) 5-year retreatment rates were 14.7 % in the TT group and 6.5 % in the TT + PND group (p = 0.01, log-rank). The rate of permanent recurrent nerve paralysis was 2 % for the TT group and 1 % for the TT + PND group (p = 0.98). The rates of permanent hypoparathyroidism were 7 versus 3 %, respectively (p = 0.12).

Conclusions

Five-year retreatment rates were lower in patients treated with PND, with no added permanent morbidity.
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Metadata
Title
Influence of Prophylactic Neck Dissection on Rate of Retreatment for Papillary Thyroid Carcinoma
Authors
Dana M. Hartl
Elisabeth Mamelle
Isabelle Borget
Sophie Leboulleux
Haïtham Mirghani
Martin Schlumberger
Publication date
01-08-2013
Publisher
Springer US
Published in
World Journal of Surgery / Issue 8/2013
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-013-2089-3

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