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European Archives of Oto-Rhino-Laryngology

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01-03-2014 | Rhinology

Prognostic value of interleukin-8 and MMP-9 in nasopharyngeal carcinoma

Authors: Daye Cheng, Hong Kong, Yunhui Li

Published in: European Archives of Oto-Rhino-Laryngology | Issue 3/2014

Abstract

Nasopharyngeal carcinoma (NPC) is one of the leading causes of cancer related death in China. One of the reasons is the absence of tumor specific prognostic markers. The aim of this study was to examine the prognostic values of interleukin-8 (IL-8) and matrix metalloproteinase-9 (MMP-9) in NPC patients. A total of 99 consecutive NPC patients and 40 healthy controls were recruited for this study. Serum levels of IL-8 and MMP-9 were evaluated in NPC patients who were followed up for 5 years. The serum levels of IL-8 and MMP-9 in NPC patients were significantly higher than those in healthy controls (IL-8 26.3 [2.9–68.0] ng/ml vs. 20.3 [2.3–38.6] ng/ml, P < 0.001; MMP-9 23.5 [3.6–52.1] ng/ml vs. 17.3 [2.6–36.9] ng/ml, P = 0.002), respectively. The serum levels of IL-8 and MMP-9 were positively correlated with the N classification (IL-8, P = 0.041, and MMP-9, P < 0.001, respectively) and clinical stage (IL-8, P = 0.022, and MMP-9, P < 0.001, respectively) in NPC patients. Analysis using the Kaplan–Meier method indicated that patients with high levels of IL-8 or MMP-9 had significantly shorter overall survival (OS) (IL-8, P = 0.012; MMP-9, P < 0.001) and disease-free survival (DFS) (IL-8, P = 0.021; MMP-9, P = 0.003) time than those with low levels of MMP-9 or IL-8. Univariate and multivariate analysis revealed elevated MMP-9 level was an independent predictor of shorter OS and DFS. Both MMP-9 and IL-8 are involved in NPC progression. MMP-9 in serum may be the clinically useful indicator for prognostic evaluation in NPC patients.

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Title: Prognostic value of interleukin-8 and MMP-9 in nasopharyngeal carcinoma
Authors: Daye Cheng
Hong Kong
Yunhui Li
Publication date: 01-03-2014
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 3/2014
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-013-2580-3

At a glance: The STEP trials

Springer Medicine

Prognostic value of interleukin-8 and MMP-9 in nasopharyngeal carcinoma

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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