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European Archives of Oto-Rhino-Laryngology

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01-03-2014 | Miscellaneous

Presence of different genotypes of Helicobacter pylori in patients with chronic tonsillitis and sleep apnoea syndrome

Authors: Eva Nártová, Jaroslav Kraus, Emil Pavlík, Petr Lukeš, Rami Katra, Jan Plzák, Libuše Kolářová, Ivan Šterzl, Jan Betka, Jaromír Astl

Published in: European Archives of Oto-Rhino-Laryngology | Issue 3/2014

Abstract

Helicobacter pylori, a well-known gastric pathogen, has been detected in the oral cavity and oropharynx in tonsillar tissue. In our study, the presence of H. pylori in the tonsillar tissue of patients with chronic tonsillitis and sleep apnoea syndrome (SAS) was investigated. The aim was to detect and genotype H. pylori for a collection of data supporting the possible role of H. pylori in the aetiology of chronic tonsillitis and SAS. Helicobacter pylori was detected by real-time polymerase chain reaction (rt-PCR). 89 patients, 60 with a diagnosis of chronic tonsillitis and 29 with SAS, were tested. In the chronic tonsillitis group, Helicobacter was detected in 48 (80 %) specimens, cagA gene was detected in 12 samples (25 %) and 12 samples were negative. In SAS group, Helicobacter was found in 24 samples (82.76 %), cagA gene was detected in 5 (20.83 %) and 5 samples (17.24 %) were negative. Helicobacter pylori-specific immunoglobulins were tested by ELISA in the serum of 57 patients only with 41 (71.93 %) showing positive. Our results on H. pylori DNA detection and H. pylori seropositivity show 26.32 % discrepancy, slightly in favour of rt-PCR (15.79 % compared to 10.53 %). The H. pylori presence in tonsillar tissue does not depend on the type of oropharyngeal disease (p = 0.756). This study shows that oropharynx constitutes an extragastric reservoir of H. pylori infection which could serve as an aetiopathogenetic factor for chronic tonsillitis and tonsillar hyperplasia by SAS. No conclusion has yet been drawn about the mechanism of the process.

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Title: Presence of different genotypes of Helicobacter pylori in patients with chronic tonsillitis and sleep apnoea syndrome
Authors: Eva Nártová
Jaroslav Kraus
Emil Pavlík
Petr Lukeš
Rami Katra
Jan Plzák
Libuše Kolářová
Ivan Šterzl
Jan Betka
Jaromír Astl
Publication date: 01-03-2014
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 3/2014
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-013-2607-9

2024 ASCO Annual Meeting

Springer Medicine

Presence of different genotypes of Helicobacter pylori in patients with chronic tonsillitis and sleep apnoea syndrome

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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