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01-11-2014 | Original Article

Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia: a multicenter study

Authors: Keita Terui, Tomoaki Taguchi, Keiji Goishi, Masahiro Hayakawa, Yuko Tazuke, Akiko Yokoi, Hajime Takayasu, Hiroomi Okuyama, Hideo Yoshida, Noriaki Usui, The Japanese Congenital Diaphragmatic Hernia Study Group

Published in: Pediatric Surgery International | Issue 11/2014

Abstract

Purpose

Gastroesophageal reflux disease (GERD) is one of the concomitant problems in infants with congenital diaphragmatic hernia (CDH). We assessed risk factors of GERD in CDH patients.

Methods

The retrospective observational study for CDH infants was conducted. Cases of CDH who were born between January 2006 and December 2010, were operated in the 9 participating institutions, and survived to discharge were included. Completion of medical therapy for GERD and incidence of surgery were primary outcomes. Kaplan–Meier survival analysis and Cox proportional hazards regression were used.

Results

In 182 cases of CDH, the medical therapies for GERD were performed in 23.8 % (40/168), and were completed in 60.0 % (24/40). Prenatal detection of CDH (HR 5.87, CI 1.6–18.8, p = 0.012) and tube feeding at discharge (HR 5.04, 95 % CI 1.3–33.1, p = 0.016) were significantly correlated with unsuccessful weaning from medical therapy. Surgery for GERD was performed in 10.7 % (18/169). Gestational age (HR 4.78, 95 % CI 1.5–21.1, p = 0.006) and diaphragmatic defect of more than 75 % (HR 4.3, 95 % CI 1.6–12.9, p = 0.005) were significantly correlated with need for antireflux surgery.

Conclusion

Diaphragmatic defect of more than 75 % was risk factor of future need for antireflux surgery.

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Title: Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia: a multicenter study
Authors: Keita Terui
Tomoaki Taguchi
Keiji Goishi
Masahiro Hayakawa
Yuko Tazuke
Akiko Yokoi
Hajime Takayasu
Hiroomi Okuyama
Hideo Yoshida
Noriaki Usui
The Japanese Congenital Diaphragmatic Hernia Study Group
Publication date: 01-11-2014
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 11/2014
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-014-3594-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia: a multicenter study

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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