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28-02-2024 | Probiotics | Original Contributions

Effects of Probiotic Use on Gastrointestinal Symptoms in the Late Postoperative Period of Bariatric Surgery: A Cross-Over, Randomized, Triple-Blind, Placebo-Controlled Study

Authors: Nathalia Ramori Farinha Wagner, Maria Clara Peixoto Lopes, Ricardo Fernandes, Cesar Augusto Taconelli, Giovanna Mozzaquatro Nascimento, Julia Pessini, Erasmo Benicio Santos de Moraes Trindade, Antonio Carlos Ligocki Campos

Published in: Obesity Surgery | Issue 4/2024

Abstract

Introduction

Despite the benefits associated with weight reduction, the anatomical and functional changes of bariatric surgery may favor the development of undesirable side effects such as the appearance of gastrointestinal symptoms (GIS). The aim of this study was to evaluate the effects of using probiotics in individuals with GIS 1 year after being submitted to Roux-en-Y Gastric Bypass (RYGB).

Materials and Methods

This is an experimental, prospective, randomized, cross-over, triple-blind, placebo-controlled study, carried out with patients 1 year after being submitted to RYGB and who reported at least one moderate GIS. Subjects were randomized into two groups and completed the two research periods: in one they received placebo capsules, in the other 50 billion CFU of probiotics (Lactobacillus acidophilus, Bifidobacterium lactis, Lactobacillus rhamnosus, Bifidobacterium longum, Lactobacillus plantarum, Bifidobacterium bifidum and Lactobacillus gasseri), both for 8 weeks, with 8 weeks of wash-out period in between, and were evaluated for the presence of Small Intestine Bacterial Overgrowth (SIBO) and GIS, through the Hydrogen breath test and Gastric Symptom Rating Scale (GSRS) questionnaire.

Results

Of a total of 56 participants, 47 individuals completed the study. No significant effects were observed in neither the gastrointestinal symptoms or in the prevalence of SIBO with the use of probiotics.

Conclusion

Supplementation of the probiotics chosen for this study does not seem to alleviate GIS or influence the improvement of SIBO in symptomatic patients after 1 year of RYGB.

Graphical Abstract

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Title: Effects of Probiotic Use on Gastrointestinal Symptoms in the Late Postoperative Period of Bariatric Surgery: A Cross-Over, Randomized, Triple-Blind, Placebo-Controlled Study
Authors: Nathalia Ramori Farinha Wagner
Maria Clara Peixoto Lopes
Ricardo Fernandes
Cesar Augusto Taconelli
Giovanna Mozzaquatro Nascimento
Julia Pessini
Erasmo Benicio Santos de Moraes Trindade
Antonio Carlos Ligocki Campos
Publication date: 28-02-2024
Publisher: Springer US
Keywords: Probiotics
Bariatric Surgery
Bariatric Surgery
Respiratory Microbiota
Published in: Obesity Surgery / Issue 4/2024
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-024-07117-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of Probiotic Use on Gastrointestinal Symptoms in the Late Postoperative Period of Bariatric Surgery: A Cross-Over, Randomized, Triple-Blind, Placebo-Controlled Study

Abstract

Introduction

Materials and Methods

Results

Conclusion

Graphical Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Materials and Methods

Results

Conclusion

Graphical Abstract

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