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Seminars in Immunopathology
Published in: Seminars in Immunopathology 1/2019

01-01-2019 | Review

Principles of adoptive T cell therapy in cancer

Authors: Özcan Met, Kasper Mølgaard Jensen, Christopher Aled Chamberlain, Marco Donia, Inge Marie Svane

Published in: Seminars in Immunopathology | Issue 1/2019

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Abstract

Adoptive cell therapy (ACT) utilizing either tumor-infiltrating lymphocyte (TIL)-derived T cells or T cells genetically engineered to express tumor recognizing receptors has emerged as a powerful and potentially curative therapy for several cancers. Many ACT-based therapies have recently entered late-phase clinical testing, with several T cell therapies already achieving regulatory approval for the treatment of patients with B cell malignancies. In this review, we briefly outline the principles of adoptively transferred T cells for the treatment of cancer.
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Metadata
Title
Principles of adoptive T cell therapy in cancer
Authors
Özcan Met
Kasper Mølgaard Jensen
Christopher Aled Chamberlain
Marco Donia
Inge Marie Svane
Publication date
01-01-2019
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 1/2019
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-018-0703-z

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Obesity Clinical Trial Summary

At a glance: The STEP trials

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Developed by: Springer Medicine

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