Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 2/2006

01-02-2006 | Gastrointestinal

Primitive mesenteric gastrointestinal stromal tumor with autonomic nerve/ganglionic differentiation presenting as a huge mass with small synchronous nodules

Authors: Antonio Basile, Joachim Kettenback, Elena Mundo, Angelo Natoli, Simona Caloggero, Marina Minciullo, Antonella Garito

Published in: European Radiology | Issue 2/2006

Login to get access

Abstract

We present a case of a primary mesenteric ectopic gastrointestinal stromal tumor. The pathologic characteristics of this neoplasm, autonomic nerve/ganglionic differentiation and presentation as a huge mass with small synchronous nodules, have not been previously described in the literature.
Literature
1.
Mazur MT, Clark HB (1983) Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol 7(6):507–519PubMed
2.
Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad TG, Matsuzawa Y, Kanakura Y, Shinomara Y, Kitamura Y (1998) Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279:577–580CrossRefPubMed
3.
Sharp RM, Ansel HJ, Keel SB (2001) Best cases from the AFIP: gastrointestinal stromal tumor. Radiographics 21:1557–1560
4.
Miettinen M, Lasota J (2001) Gastrointestinal stromal tumors: definition, clinical, histological, immuno-histochemical, and molecular genetic features and differential diagnosis. Virchows Arch 438:1–12CrossRefPubMed
5.
Reith JD, Goldblum JR, Lyles RH, Weiss SW (2000) Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Path 13(5):577–585CrossRefPubMed
6.
Kim HC, Lee JM, Kim SH, Kim KW, Lee W, Kim YJ, Han JK, Choj BI (2004) Primary gastrointestinal stromal tumors in the omentum and mesentery: CT findings and pathologic correlations. Am J Roentgenol 182:1463–1467
7.
Ghanem N, Altehoefer C, Furtwängler A, Winterer J, Schäfer O, Springer O, Kotter E, Langer M (2003) Computed tomography in gastrointestinal stromal tumors. Eur Radiol 13:1669–1678CrossRefPubMed
8.
Miettinen M, Monihan JM, Sarlomo-Rikala M, Kovatich AJ, Carr Emory TS, Sobin LH (1999) Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immuno-histochemical study of 26 cases. Am J Surg Pathol 23:1109–1118CrossRefPubMed
9.
Suster S (1996) Gastrointestinal stromal tumors. Sem Diagn Pathol 13:297–313
10.
Morgan BK, Compton C, Talbert M, Gallagher WJ, Wood WJC (1990) Benign smooth muscle tumors of the gastrointestinal tract. Ann Surg 211:63–66
11.
Pidhorecky I, Cheney RT, Kraybill WG, Gibbs JF (2000) Gastrointestinal stromal tumors: current diagnosis, biologic behavior, and management. Ann Surg Oncol 7:705–712PubMed
12.
Kindblom LG, Remotti HE, Aldenberg F, Meis-Kindblom JM (1998) Gastrointestinal pacemaker cell tumor (GIPACT). Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cell of Cajal. Am J Pathol 152:1259–1269PubMed
13.
Sincar K, Hewlett BR, Riddel RH (1998) Most gastrointestinal stromal tumors arise from interstitial cells of Cajal. Mod Pathol 11:71A
14.
Moskaluk CA, Tian Q, Marshall CR, Rumpel CA, Franquemont DW, Frierson HF (1999) Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors. Oncogene 18:1897–1902CrossRefPubMed
15.
Appelman HD, Helwig EB (1977) Sarcomas of the stomach. Am J Clin Pathol 67:2–10PubMed
16.
Evans HL (1985) Smooth muscle tumors of the gastrointestinal tract: a study of 56 cases for a minimum of 10 years. Cancer 56:2242–2250PubMed
17.
Ballarini C, Intra M, Ceretti AP, Prestipino F, Bianchi FM, Sparacio F, Berti E, Perrone S, Silva F (1998) Gastrointestinal stromal tumors: a “benign” tumor with hepatic metastasis after 11 years. Tumori 84:78–81
18.
Berman JJ, O’Leary TJ (2001) Gastrointestinal stromal tumor workshop. Human Pathol 32:578–582
19.
Levy AD, Remotti HE, Thompson WM, Sobin LH, Miettinen M (2003) Gastrointestinal stromal tumors: radiologic features with pathologic correlation. Radiographics 23:283–304PubMed
20.
Gorospe L, Simon MJ, Lima F, Esteban I, Madrid C, Hitos E (2002) Primary mesenteric tumor with phenotypical features of gastrointestinal stromal tumors. Eur Radiol 12:S82–S85CrossRefPubMed
21.
Healy JC, Reznek RH (1998) The peritoneum, mesenteries and omenta: normal anatomy and pathologic processes. Eur Radiol 8(6):886–900CrossRefPubMed
22.
Coakley FV, Hricak H (1999) Imaging of peritoneal and mesenteric disease: key concepts for the clinical radiologist. Clin Radiol 54:563–574CrossRefPubMed
23.
Hasegawa S, Semelka RC, Noone TC, Woosley JT, Marcos HB, Kenney PJ, Siegelman ES (1998) Gastric stromal sarcomas: correlation of MR imaging and histopathologic findings in nine patients. Radiology 208:591–595
24.
Stoupis C, Ros PR, Abbitt PL, Burton SS, Gauger J (1994) Bubbles in the belly: imaging of cystic mesenteric and omental masses. Radiographics 14:729–737
25.
Herrera GA, Pinto de Moraes HP, Grizzle WE, Han SG (1984) Malignant small bowel neoplasm of enteric plexus derivation (plexosarcoma): light and electron microscopy study confirming the origin of the neoplasm. Dig Dis Sci 29:275–284
26.
Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CDM, Joensuu H (2002) Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 347:472–480CrossRefPubMed
27.
van Oosterom AT, Judson I, Verweij J, Stroobants S, Donato di Paola E, Dimitrijevic S, Martens M, Webb A, Sciot R, Van Glabbeke M, Silberman S, Nielsen OS (2001) Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet 358:1421–1423CrossRefPubMed
Metadata
Title
Primitive mesenteric gastrointestinal stromal tumor with autonomic nerve/ganglionic differentiation presenting as a huge mass with small synchronous nodules
Authors
Antonio Basile
Joachim Kettenback
Elena Mundo
Angelo Natoli
Simona Caloggero
Marina Minciullo
Antonella Garito
Publication date
01-02-2006
Publisher
Springer-Verlag
Published in
European Radiology / Issue 2/2006
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-005-2680-6

Other articles of this Issue 2/2006

European Radiology 2/2006 Go to the issue

Radiological Education

Comparison of radiology residency programs in ten countries

Computer Tomography

Optimized image reconstruction for detection of deep venous thrombosis at multidetector-row CT venography

Urogenital

Diagnosis of endometriosis with imaging: a review

Cardiac

Left ventricular function studied with MDCT

Technical Developments

Automatic determination of minimal cardiac motion phases for computed tomography imaging: initial experience

Head and Neck

Gray-scale three-dimensional sonography of thyroid nodules: feasibility of the method and preliminary studies