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Current Rheumatology Reports

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Open Access 03-08-2022 | Primary Immunodeficiency | Vasculitis (C Dejaco and C Duftner, Section Editors)

Spectrum of Large- and Medium-Vessel Vasculitis in Adults: Neoplastic, Infectious, Drug-Induced, Autoinflammatory, and Primary Immunodeficiency Diseases

Authors: Fabian Lötscher, Roxana Pop, Pascal Seitz, Mike Recher, Luca Seitz

Published in: Current Rheumatology Reports | Issue 10/2022

Abstract

Purpose of Review

To provide a comprehensive review of drugs and neoplastic, infectious, autoinflammatory, and immunodeficiency diseases causing medium- to large-vessel vasculitis in adults with emphasis on information essential for the initial diagnostic process.

Recent Findings

Entities with medium- to large-vessel vasculitis as clinical manifestations have been described recently (e.g., adenosine deaminase-2 deficiency, VEXAS-Syndrome), and vasculitis in established autoinflammatory or immunodeficiency diseases is increasingly being identified.

Summary

In the diagnostic process of medium- to large-vessel vasculitis in adults, a large variety of rare diseases should be included in the differential diagnosis, especially if diagnosis is made without histologic confirmation and in younger patients. Although these disorders should be considered, they will undoubtedly remain rare in daily practice.

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Hellmich B, Agueda A, Monti S, Buttgereit F, de Boysson H, Brouwer E, et al. 2018 Update of the EULAR recommendations for the management of large vessel vasculitis. Ann Rheum Dis. 2020;79(1):19–30. https://doi.org/10.1136/annrheumdis-2019-215672.CrossRefPubMed

Seitz L, Lötscher F. The intima-media thickness in suspected giant cell arteritis-sometimes it is worth taking a closer look. Rheumatology (Oxford). 2021;60(7):3039–41. https://doi.org/10.1093/rheumatology/keab316.CrossRef

Seitz L, Seitz P, Pop R, Lötscher F. Spectrum of large and medium vessel vasculitis in adults: primary vasculitides, arthritides, connective tissue and fibroinflammatory diseases. Curr Rheumatol Rep.

Martins-Martinho J, Dourado E, Khmelinskii N, Espinosa P, Ponte C. Localized forms of vasculitis. Curr Rheumatol Rep. 2021;23(7):49. https://doi.org/10.1007/s11926-021-01012-y.CrossRefPubMedPubMedCentral

Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1–11. https://doi.org/10.1002/art.37715.CrossRefPubMed

Abbara S, Grateau G, Ducharme-Bénard S, Saadoun D, Georgin-Lavialle S. Association of vasculitis and familial Mediterranean fever. Front Immunol. 2019;10:763. https://doi.org/10.3389/fimmu.2019.00763.CrossRefPubMedPubMedCentral

Watad A, Tiosano S, Yahav D, Comaneshter D, Shoenfeld Y, Cohen AD, Amital H. Behçet’s disease and familial Mediterranean fever: Two sides of the same coin or just an association? A cross-sectional study. Eur J Intern Med. 2017;39:75–8. https://doi.org/10.1016/j.ejim.2016.10.011.CrossRefPubMed

Schwartz T, Langevitz P, Zemer D, Gazit E, Pras M, Livneh A. Behçet’s disease in Familial Mediterranean fever: characterization of the association between the two diseases. Semin Arthritis Rheum. 2000;29(5):286–95. https://doi.org/10.1016/s0049-0172(00)80015-3.CrossRefPubMed

Zihni FY, Kalfa M, Ocakçı PT, Tarhan F, Parildar M, Keser G, Aksu K. Coexistence of Takayasu’s arteritis with familial Mediterranean fever. Rheumatol Int. 2012;32(6):1675–8. https://doi.org/10.1007/s00296-011-1853-7.CrossRefPubMed

10.

Zenone T, Puget M. Cogan’s syndrome in a patient with familial Mediterranean fever. Clin Exp Rheumatol. 2012;30(1):141.PubMed

11.

Sy A, Khalidi N, Dehghan N, Barra L, Carette S, Cuthbertson D, et al.; Vasculitis Clinical Research Consortium (VCRC); Canadian Vasculitis Network (CanVasc). Vasculitis in patients with inflammatory bowel diseases: a study of 32 patients and systematic review of the literature. Semin Arthritis Rheum. 2016;45(4):475–82. https://doi.org/10.1016/j.semarthrit.2015.07.006.

12.

Bekele DI, Warrington KJ, Koster MJ. Giant cell arteritis associated with inflammatory bowel disease: a case-series and review of the literature. Rheumatol Int. 2021;41(2):487–92. https://doi.org/10.1007/s00296-020-04727-w.CrossRefPubMed

13.

Shirai T, Hanaoka R, Goto Y, Kojima I, Ishii Y, Hoshi Y, et al. Takayasu arteritis coexisting with sclerosing osteomyelitis. Intern Med. 2018;57(13):1929–34. https://doi.org/10.2169/internalmedicine.0329-17.CrossRefPubMedPubMedCentral

14.

Hoshino A, Sawada T, Matsuda M, Miyagawa S, Nakamura T, Matsubara H. A case of Takayasu’s arteritis and aortic regurgitation, which presented much difficulty in the diagnosing process because of complicated osteomyelitis and non-typical manifestations. J Cardiol. 2009;54(1):148–52. https://doi.org/10.1016/j.jjcc.2008.10.007.CrossRefPubMed

15.

•• Staels F, Collignon T, Betrains A, Gerbaux M, Willemsen M, Humblet-Baron S, et al. Monogenic adult-onset inborn errors of immunity. Front Immunol. 2021;12:753978. https://doi.org/10.3389/fimmu.2021.753978. Very detailed and conceptually strong review about this important topic; includes a practical figure with graphic illustration of the oldest age-of-onset reported for every gene that is reviewed and practical tables.

16.

Bonilla FA, Barlan I, Chapel H, Costa-Carvalho BT, Cunningham-Rundles C, de la Morena MT, et al. International Consensus Document (ICON): common variable immunodeficiency disorders. J Allergy Clin Immunol Pract. 2016;4(1):38–59. https://doi.org/10.1016/j.jaip.2015.07.025.CrossRefPubMed

17.

• Janssen LMA, van der Flier M, de Vries E. Lessons learned from the clinical presentation of common variable immunodeficiency disorders: a systematic review and meta-analysis. Front Immunol. 2021;12:620709. https://doi.org/10.3389/fimmu.2021.620709. Extensive overview about the myriads of associated manifestations of CVID.

18.

Jerschow E, De Vos GS, Hudes G, Rubinstein A, Lipsitz EC, Rosenstreich D. A case of common variable immunodeficiency syndrome associated with Takayasu arteritis. Ann Allergy Asthma Immunol. 2007;98(2):196–9. https://doi.org/10.1016/S1081-1206(10)60697-7.CrossRefPubMed

19.

Tudela P, Bonal J, Romero R, Caralps A. Common variable immunodeficiency and Takayasu’s arteritis. Nephron. 1990;55(3):351–2. https://doi.org/10.1159/000185996.CrossRefPubMed

20.

Skeik N, Rumery KK, Udayakumar PD, Crandall BM, Warrington KJ, Sullivan TM. Concurrent Takayasu arteritis with common variable immunodeficiency and moyamoya disease. Ann Vasc Surg. 2013;27(2):240.e13-8. https://doi.org/10.1016/j.avsg.2012.09.003.CrossRef

21.

Candotti F. Clinical manifestations and pathophysiological mechanisms of the Wiskott-Aldrich syndrome. J Clin Immunol. 2018;38(1):13–27. https://doi.org/10.1007/s10875-017-0453-z.CrossRefPubMed

22.

Sudhakar M, Rikhi R, Loganathan SK, Suri D, Singh S. Autoimmunity in Wiskott-Aldrich syndrome: updated perspectives. Appl Clin Genet. 2021;14:363–88. https://doi.org/10.2147/TACG.S213920.CrossRefPubMedPubMedCentral

23.

Makar RR, Gordins P, Spickett G, Williams R, Lambert D. Endovascular repair of descending thoracic aortic aneurysm in patient with Wiskott-Aldrich syndrome. J Vasc Surg. 2013;58(5):1385–7. https://doi.org/10.1016/j.jvs.2012.12.081.CrossRefPubMed

24.

Johnston SL, Unsworth DJ, Dwight JF, Kennedy CT. Wiskott-Aldrich syndrome, vasculitis and critical aortic dilatation. Acta Paediatr. 2001;90(11):1346–8. https://doi.org/10.1080/080352501317130452.CrossRefPubMed

25.

Byram K, Calabrese LH, Fernandez J. Comorbid vasculitis among patients in a national primary immunodeficiency database [abstract]. Arthritis Rheumatol. 2018; 70(suppl 10). https://acrabstracts.org/abstract/comorbid-vasculitis-among-patients-in-a-national-primary-immunodeficiency-database/. Accessed 8 Jan 2022.

26.

McCluggage WG, Armstrong DJ, Maxwell RJ, Ellis PK, McCluskey DR. Systemic vasculitis and aneurysm formation in the Wiskott-Aldrich syndrome. J Clin Pathol. 1999;52(5):390–2. https://doi.org/10.1136/jcp.52.5.390.CrossRefPubMedPubMedCentral

27.

• Pinto B, Deo P, Sharma S, Syal A, Sharma A. Expanding spectrum of DADA2: a review of phenotypes, genetics, pathogenesis and treatment. Clin Rheumatol. 2021;40(10):3883-3896. https://doi.org/10.1007/s10067-021-05711-w. Gives a detailed overview about the clinical manifestations of this novel syndrome.

28.

Jee H, Huang Z, Baxter S, Huang Y, Taylor ML, Henderson LA, et al. Comprehensive analysis of ADA2 genetic variants and estimation of carrier frequency driven by a function-based approach. J Allergy Clin Immunol. 2022;149(1):379–87. https://doi.org/10.1016/j.jaci.2021.04.034.CrossRefPubMed

29.

• Barron KS, Aksentijevich I, Deuitch NT, Stone DL, Hoffmann P, Videgar-Laird R, et al. The spectrum of the deficiency of adenosine deaminase 2: an observational analysis of a 60 patient cohort. Front Immunol. 2022;12:811473. https://doi.org/10.3389/fimmu.2021.811473. Apart from the clinical manifestations, details on laboratory findings in ADA2-deficiency is provided.

30.

Dimachkie MD, Fraga GR, Moura NS, Springer JM. A rare case of adenosine deaminase 2 deficiency presenting with temporal arteritis. J Clin Rheumatol. 2021;27(7):e251–2. https://doi.org/10.1097/RHU.0000000000001384.CrossRefPubMed

31.

Mekinian A, Grignano E, Braun T, Decaux O, Liozon E, Costedoat-Chalumeau N, et al. Systemic inflammatory and autoimmune manifestations associated with myelodysplastic syndromes and chronic myelomonocytic leukaemia: a French multicentre retrospective study. Rheumatology (Oxford). 2016;55(2):291–300. https://doi.org/10.1093/rheumatology/kev294.CrossRef

32.

Grignano E, Mekinian A, Braun T, Liozon E, Hamidou M, Decaux O, et al. Autoimmune and inflammatory diseases associated with chronic myelomonocytic leukemia: a series of 26 cases and literature review. Leuk Res. 2016;47:136–41. https://doi.org/10.1016/j.leukres.2016.05.013.CrossRefPubMed

33.

Papo M, Friedrich C, Delaval L, Boysson H, Viallard JF, Bachmeyer C, et al. Myeloproliferative neoplasms and clonal haematopoiesis in patients with giant cell arteritis: a case-control and exploratory study. Rheumatology (Oxford). 2022;61(2):775–80. https://doi.org/10.1093/rheumatology/keab337.CrossRef

34.

Roupie AL, Guedon A, Terrier B, Lahuna C, Jachiet V, Regent A, et al. Vasculitis associated with myelodysplastic syndrome and chronic myelomonocytic leukemia: French multicenter case-control study. Semin Arthritis Rheum. 2020;50(5):879–84. https://doi.org/10.1016/j.semarthrit.2020.07.002.CrossRefPubMed

35.

Roupie AL, de Boysson H, Thietart S, Carrat F, Seguier J, Terriou L, et al. Giant-cell arteritis associated with myelodysplastic syndrome: French multicenter case control study and literature review. Autoimmun Rev. 2020;19(2): 102446. https://doi.org/10.1016/j.autrev.2019.102446.CrossRefPubMed

36.

Hamidou MA, Boumalassa A, Larroche C, El Kouri D, Blétry O, Grolleau JY. Systemic medium-sized vessel vasculitis associated with chronic myelomonocytic leukemia. Semin Arthritis Rheum. 2001;31(2):119–26. https://doi.org/10.1053/sarh.2001.27717.CrossRefPubMed

37.

Nardi-Agmon I, Hamdan A, Eisen A, Orvin K, Porter A, et al. Diffused coronary involvement in Takayasu arteritis with concomitant malignancy. Clin Rheumatol. 2021. https://doi.org/10.1007/s10067-021-06000-2.CrossRefPubMed

38.

Yuce Inel T, Gulcu A, Karakas A, Erdogan Yucel E, Onen F. Coexistence of Takayasu arteritis and chronic myeloid leukemia: coincidental or paraneoplastic phenomenon? Int J Rheum Dis. 2021;24(9):1213–6. https://doi.org/10.1111/1756-185X.14186.CrossRefPubMed

39.

Hutson TE, Hoffman GS. Temporal concurrence of vasculitis and cancer: a report of 12 cases. Arthritis Care Res. 2000;13(6):417–23. https://doi.org/10.1002/1529-0131(200012)13:6<417::aid-art13>3.0.co;2-tCrossRefPubMed

40.

Deshayes S, Liozon E, Chanson N, Sacré K, Moulinet T, Blanchard-Delaunay C, et al. Concomitant association of giant cell arteritis and malignancy: a multicenter retrospective case-control study. Clin Rheumatol. 2019;38(5):1243–9. https://doi.org/10.1007/s10067-018-04407-y.CrossRefPubMed

41.

Buhl T, Bertsch HP, Raab BW, Kaune KM, Vasko R, Strutz F, et al. Fulminant polyarteritis nodosa associated with acute myeloid leukaemia resulted in bilateral lower leg amputation. Rheumatology (Oxford). 2009;48(9):1170–2. https://doi.org/10.1093/rheumatology/kep173.CrossRef

42.

Chircop I, Boespflug A, Cini A, Lega JC, Dalle S. Paraneoplastic polyarteritis nodosa in a patient with cutaneous T-cell lymphoma. Lancet Haematol. 2021;8(3): e240. https://doi.org/10.1016/S2352-3026(20)30393-8.CrossRefPubMed

43.

Salvarani C, Brown RD Jr, Christianson TJH, Huston J 3rd, Ansell SM, Giannini C, et al. Primary central nervous system vasculitis associated with lymphoma. Neurology. 2018;90(10):e847–55. https://doi.org/10.1212/WNL.0000000000005062.CrossRefPubMed

44.

Wooten MD, Jasin HE. Vasculitis and lymphoproliferative diseases. Semin Arthritis Rheum. 1996;26(2):564–74. https://doi.org/10.1016/s0049-0172(96)80044-8.CrossRefPubMed

45.

Hasler P, Kistler H, Gerber H. Vasculitides in hairy cell leukemia. Semin Arthritis Rheum. 1995;25(2):134–42. https://doi.org/10.1016/s0049-0172(95)80026-3.CrossRefPubMed

46.

Lowe J, Russell NH. Cerebral vasculitis associated with hairy cell leukemia. Cancer. 1987;60(12):3025–8.https://doi.org/10.1002/1097-0142(19871215)60:12<3025::aid-cncr2820601228>3.0.co;2-jCrossRefPubMed

47.

•• Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins JC, et al. Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease. N Engl J Med. 2020;383(27):2628-2638. https://doi.org/10.1056/NEJMoa2026834. First description of this novel syndrome, which was found using a genotype driven approach.

48.

Georgin-Lavialle S, Terrier B, Guedon AF, Heiblig M, Comont T, Lazaro E, et al. Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 French patients. Br J Dermatol. 2021. https://doi.org/10.1111/bjd.20805.CrossRefPubMed

49.

Kermani TA, Ham EK, Camilleri MJ, Warrington KJ. Polyarteritis nodosa-like vasculitis in association with minocycline use: a single-center case series. Semin Arthritis Rheum. 2012;42(2):213–21. https://doi.org/10.1016/j.semarthrit.2012.03.006.CrossRefPubMed

50.

Yokota K, Kurihara I, Nakamura T, Nakatsuka S, Miyashita K, Kobayashi S, et al. Remission of angiographically confirmed minocycline-induced renal polyarteritis nodosa: a case report and literature review. Intern Med. 2022;61(1):103–10. https://doi.org/10.2169/internalmedicine.7340-21.CrossRefPubMed

51.

Daxini A, Cronin K, Sreih AG. Vasculitis associated with immune checkpoint inhibitors-a systematic review. Clin Rheumatol. 2018;37(9):2579–84. https://doi.org/10.1007/s10067-018-4177-0.CrossRefPubMed

52.

Salem JE, Manouchehri A, Moey M, Lebrun-Vignes B, Bastarache L, Pariente A, et al. Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study. Lancet Oncol. 2018;19(12):1579–89. https://doi.org/10.1016/S1470-2045(18)30608-9.CrossRefPubMedPubMedCentral

53.

Taimen K, Heino S, Kohonen I, Relas H, Huovinen R, Hänninen A, et al. Granulocyte colony-stimulating factor- and chemotherapy-induced large-vessel vasculitis: six patient cases and a systematic literature review. Rheumatol Adv Pract. 2020;4(1):rkaa004. https://doi.org/10.1093/rap/rkaa004.

54.

Hoshina H, Takei H. Granulocyte-colony stimulating factor-associated aortitis in cancer: a systematic literature review. Cancer Treat Res Commun. 2021;29: 100454. https://doi.org/10.1016/j.ctarc.2021.100454.CrossRefPubMed

55.

Al-Heilfi A, Nataraja C, Cooley H, Batt T. Large-vessel vasculitis in graft-versus-host disease: a case report. J Med Case Rep. 2021;15(1):478. https://doi.org/10.1186/s13256-021-03067-y.CrossRefPubMedPubMedCentral

56.

Sostak P, Padovan CS, Eigenbrod S, Roeber S, Segerer S, Schankin C, et al. Cerebral angiitis in four patients with chronic GVHD. Bone Marrow Transplant. 2010;45(7):1181–8. https://doi.org/10.1038/bmt.2009.323.CrossRefPubMed

57.

•• Nigrovic PA, Lee PY, Hoffman HM. Monogenic autoinflammatory disorders: conceptual overview, phenotype, and clinical approach. J Allergy Clin Immunol. 2020;146(5):925–937. https://doi.org/10.1016/j.jaci.2020.08.017. Detailed, well-structured and comprehensive overview about the monogenic autoinflammatory disorders.

58.

• Demir S, Sag E, Dedeoglu F, Ozen S. Vasculitis in systemic autoinflammatory diseases. Front Pediatr. 2018;6:377. https://doi.org/10.3389/fped.2018.00377. Well-structured and comprehensive overview about vasculitis in systemic autoinflammatory diseases.

59.

Ozen S, Ben-Chetrit E, Bakkaloglu A, Gur H, Tinaztepe K, Calguneri M, et al. Polyarteritis nodosa in patients with Familial Mediterranean Fever (FMF): a concomitant disease or a feature of FMF? Semin Arthritis Rheum. 2001;30(4):281–7. https://doi.org/10.1053/sarh.2001.19958.CrossRefPubMed

60.

Khatibi K, Heit JJ, Telischak NA, Elbers JM, Do HM. Cerebral vascular findings in PAPA syndrome: cerebral arterial vasculopathy or vasculitis and a posterior cerebral artery dissecting aneurysm. J Neurointerv Surg. 2016;8(8): e29. https://doi.org/10.1136/neurintsurg-2015-011753.rep.CrossRefPubMed

61.

Videira G, Malaquias MJ, Laranjinha I, Martins R, Taipa R, Magalhães M. Diagnosis of Aicardi-Goutières syndrome in adults: a case series. Mov Disord Clin Pract. 2020;7(3):303–7. https://doi.org/10.1002/mdc3.12903.CrossRefPubMedPubMedCentral

62.

Thiele H, du Moulin M, Barczyk K, George C, Schwindt W, Nürnberg G, et al. Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression. Hum Mutat. 2010;31(11):E1836–50. https://doi.org/10.1002/humu.21357.CrossRefPubMedPubMedCentral

63.

Staels F, Betrains A, Doubel P, Willemsen M, Cleemput V, Vanderschueren S, et al. Adult-onset ANCA-associated vasculitis in SAVI: extension of the phenotypic spectrum, case report and review of the literature. Front Immunol. 2020;11: 575219. https://doi.org/10.3389/fimmu.2020.575219.CrossRefPubMedPubMedCentral

64.

Zhou Q, Wang H, Schwartz DM, Stoffels M, Park YH, Zhang Y, et al. Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet. 2016;48(1):67–73. https://doi.org/10.1038/ng.3459.Firstdescriptionofthisnoveldisorder.CrossRefPubMed

65.

Aeschlimann FA, Batu ED, Canna SW, Go E, Gül A, Hoffmann P, et al. A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease. Ann Rheum Dis. 2018;77(5):728–35. https://doi.org/10.1136/annrheumdis-2017-212403.CrossRefPubMed

66.

McGonagle D, McDermott MF. A proposed classification of the immunological diseases. PLoS Med. 2006;3(8): e297. https://doi.org/10.1371/journal.pmed.0030297.CrossRefPubMedPubMedCentral

67.

Yavne Y, Tiosano S, Ben-Ami D, Watad A, Guy A, Comaneshter D, et al. Giant cell arteritis and inflammatory bowel disease - is there a connection? Results from a population-based study. Autoimmun Rev. 2018;17(11):1134–7. https://doi.org/10.1016/j.autrev.2018.06.003.CrossRefPubMed

68.

Moiseev S, Cohen Tervaert JW, Arimura Y, Bogdanos DP, Csernok E, et al. 2020 international consensus on ANCA testing beyond systemic vasculitis. Autoimmun Rev. 2020;19(9): 102618. https://doi.org/10.1016/j.autrev.2020.102618.CrossRefPubMed

69.

Humbert S, Guilpain P, Puéchal X, Terrier B, Rivière S, Mahr A, et al.; French Vasculitis Study Group. Inflammatory bowel diseases in anti-neutrophil cytoplasmic antibody-associated vasculitides: 11 retrospective cases from the French Vasculitis Study Group. Rheumatology (Oxford). 2015;54(11):1970–5. https://doi.org/10.1093/rheumatology/kev199.

70.

Bernstein CN, Eliakim A, Fedail S, Fried M, Gearry R, et al. World Gastroenterology Organisation Global Guidelines Inflammatory Bowel Disease: update August 2015. J Clin Gastroenterol. 2016;50(10):803–18.CrossRef

71.

Valenti S, Gallizzi R, De Vivo D, Romano C. Intestinal Behçet and Crohn’s disease: two sides of the same coin. Pediatr Rheumatol Online J. 2017;15(1):33. https://doi.org/10.1186/s12969-017-0162-4.CrossRefPubMedPubMedCentral

72.

Vavricka SR, Greuter T, Scharl M, Mantzaris G, Shitrit AB, Filip R, et al. Cogan’s syndrome in patients with inflammatory bowel disease -a case series. J Crohns Colitis. 2015;9(10):886–90. https://doi.org/10.1093/ecco-jcc/jjv128.CrossRefPubMed

73.

Tangye SG, Al-Herz W, Bousfiha A, Cunningham-Rundles C, Franco JL, Holland SM, et al. The ever-increasing array of novel inborn errors of immunity: an interim update by the IUIS Committee. J Clin Immunol. 2021;41(3):666–79. https://doi.org/10.1007/s10875-021-00980-1.CrossRefPubMedPubMedCentral

74.

Hill F, Yonkof J, Chaitanya Arudra SK, Thomas J, Altorok N. Successful treatment of ANCA-associated vasculitis in the setting of common variable immunodeficiency using rituximab. Am J Ther. 2016;23(5):e1239–45. https://doi.org/10.1097/MJT.0000000000000323.CrossRefPubMed

75.

Najem CE, Springer J, Prayson R, Culver DA, Fernandez J, Tavee J, Hajj-Ali RA. Intra cranial granulomatous disease in common variable immunodeficiency: case series and review of the literature. Semin Arthritis Rheum. 2018;47(6):890–6. https://doi.org/10.1016/j.semarthrit.2017.10.014.CrossRefPubMed

76.

Pagnini I, Simonini G, Lippi F, Azzari C, Cimaz R. Cutaneous polyarteritis nodosa and common variable immunodeficiency: a previously unreported association. Clin Exp Rheumatol. 2012;30(1 Suppl 70):S169.PubMed

77.

• Schepp J, Proietti M, Frede N, Buchta M, Hübscher K, Rojas Restrepo J, et al. Screening of 181 patients with antibody deficiency for deficiency of adenosine deaminase 2 sheds new light on the disease in adulthood. Arthritis Rheumatol. 2017;69(8):1689-1700. https://doi.org/10.1002/art.40147. A reminder to think of ADA-2-deficiency in patients with antibody deficiencies.

78.

Ochs HD, Filipovich AH, Veys P, Cowan MJ, Kapoor N. Wiskott-Aldrich syndrome: diagnosis, clinical and laboratory manifestations, and treatment. Biol Blood Marrow Transplant. 2009;15(1 Suppl):84–90. https://doi.org/10.1016/j.bbmt.2008.10.007.CrossRefPubMed

79.

Fayand A, Chasset F, Boutboul D, Queyrel V, Tieulié N, Guichard I, et al. DADA2 diagnosed in adulthood versus childhood: a comparative study on 306 patients including a systematic literature review and 12 French cases. Semin Arthritis Rheum. 2021;51(6):1170–9. https://doi.org/10.1016/j.semarthrit.2021.09.001.CrossRefPubMed

80.

Staels F, Betrains A, Willemsen M, Corvelyn A, Tousseyn T, Dierickx D, et al. Inflammatory aortitis in a patient with type 2 hyper IgM syndrome. Rheumatology (Oxford). 2021;60(3):e87–9. https://doi.org/10.1093/rheumatology/keaa573.CrossRef

81.

Maeshima K, Ishii K, Shibata H. An Adult Fatal Case with a STAT1 Gain-of-function mutation associated with multiple autoimmune diseases. J Rheumatol. 2019;46(3):325–7. https://doi.org/10.3899/jrheum.180210.CrossRefPubMed

82.

Yavuz H, Chee R. A review on the vascular features of the hyperimmunoglobulin E syndrome. Clin Exp Immunol. 2010;159(3):238–44. https://doi.org/10.1111/j.1365-2249.2009.04044.x.CrossRefPubMedPubMedCentral

83.

Aydin SE, Kilic SS, Aytekin C, Kumar A, Porras O, Kainulainen L, et al.; inborn errors working party of EBMT. DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients. J Clin Immunol. 2015;35(2):189–98. https://doi.org/10.1007/s10875-014-0126-0.

84.

Solans-Laqué R, Bosch-Gil JA, Pérez-Bocanegra C, Selva-O’Callaghan A, Simeón-Aznar CP, Vilardell-Tarres M. Paraneoplastic vasculitis in patients with solid tumors: report of 15 cases. J Rheumatol. 2008;35(2):294–304.PubMed

85.

Fain O, Hamidou M, Cacoub P, Godeau B, Wechsler B, Pariès J, et al. Vasculitides associated with malignancies: analysis of sixty patients. Arthritis Rheum. 2007;57(8):1473–80. https://doi.org/10.1002/art.23085.CrossRefPubMed

86.

Ungprasert P, Sanguankeo A, Upala S, Knight EL. Risk of malignancy in patients with giant cell arteritis and polymyalgia rheumatica: a systematic review and meta-analysis. Semin Arthritis Rheum. 2014;44(3):366–70. https://doi.org/10.1016/j.semarthrit.2014.06.004.CrossRefPubMed

87.

Fallah M, Liu X, Ji J, Försti A, Sundquist K, Hemminki K. Autoimmune diseases associated with non-Hodgkin lymphoma: a nationwide cohort study. Ann Oncol. 2014;25(10):2025–30. https://doi.org/10.1093/annonc/mdu365.CrossRefPubMed

88.

Obiorah IE, Patel BA, Groarke EM, Wang W, Trick M, Ombrello AK, et al. Benign and malignant hematologic manifestations in patients with VEXAS syndrome due to somatic mutations in UBA1. Blood Adv. 2021;5(16):3203–15. https://doi.org/10.1182/bloodadvances.2021004976.CrossRefPubMedPubMedCentral

89.

Misra D, Patro P, Sharma A. Drug-induced vasculitis. Indian J Rheumatol. 2019;14(5):S3-9.

90.

• Grau RG. Drug-induced vasculitis: new insights and a changing lineup of suspects. Curr Rheumatol Rep. 2015;17(12):71. https://doi.org/10.1007/s11926-015-0545-9. Well written overview about the broad spectrum of drug-induced vasculitis.

91.

Gutiérrez-González LA. Biological therapy-induced systemic vasculitis. Curr Rheumatol Rep. 2016;18(7):39. https://doi.org/10.1007/s11926-016-0588-6.CrossRefPubMed

92.

Ramos-Casals M, Brito-Zerón P, Muñoz S, Soria N, Galiana D, Bertolaccini L, et al. Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases. Medicine (Baltimore). 2007;86(4):242–51. https://doi.org/10.1097/MD.0b013e3181441a68.CrossRef

93.

Kunchok A, Aksamit AJ Jr, Davis JM 3rd, Kantarci OH, Keegan BM, Pittock SJ, et al. Association between tumor necrosis factor inhibitor exposure and inflammatory central nervous system events. JAMA Neurol. 2020;77(8):937–46. https://doi.org/10.1001/jamaneurol.2020.1162.CrossRefPubMed

94.

Felicetti P, Trotta F, Bonetto C, Santuccio C, Brauchli Pernus Y, Burgner D, et al. Spontaneous reports of vasculitis as an adverse event following immunization: a descriptive analysis across three international databases. Vaccine. 2016;34(51):6634–40. https://doi.org/10.1016/j.vaccine.2015.09.027.CrossRefPubMed

95.

Liozon E, Parreau S, Filloux M, Dumonteil S, Gondran G, Bezanahary H, et al. Giant cell arteritis or polymyalgia rheumatica after influenza vaccination: a study of 12 patients and a literature review. Autoimmun Rev. 2021;20(2): 102732. https://doi.org/10.1016/j.autrev.2020.102732.CrossRefPubMed

96.

Mettler C, Jonville-Bera AP, Grandvuillemin A, Treluyer JM, Terrier B, Chouchana L. Risk of giant cell arteritis and polymyalgia rheumatica following COVID-19 vaccination: a global pharmacovigilance study. Rheumatology (Oxford). 2022;61(2):865–7. https://doi.org/10.1093/rheumatology/keab756.CrossRef

97.

Amos SM, Duong CP, Westwood JA, Ritchie DS, Junghans RP, Darcy PK, et al. Autoimmunity associated with immunotherapy of cancer. Blood. 2011;118(3):499–509. https://doi.org/10.1182/blood-2011-01-325266.CrossRefPubMed

98.

•• Zhang H, Watanabe R, Berry GJ, Vaglio A, Liao YJ, Warrington KJ, et al. Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis. Proc Natl Acad Sci U S A. 2017;114(6):E970-E979. https://doi.org/10.1073/pnas.1616848114. Important work linking immunoinhibitory checkpoint deficiency with vasculitis (GCA), providing pathophysiologic insight and opening new therapeutic approaches.

99.

Watanabe R, Zhang H, Berry G, Goronzy JJ, Weyand CM. Immune checkpoint dysfunction in large and medium vessel vasculitis. Am J Physiol Heart Circ Physiol. 2017;312(5):H1052–9. https://doi.org/10.1152/ajpheart.00024.2017.CrossRefPubMedPubMedCentral

100.

• Crout TM, Lennep DS, Kishore S, Majithia V. Systemic vasculitis associated with immune check point inhibition: analysis and review. Curr Rheumatol Rep. 2019;21(6):28. https://doi.org/10.1007/s11926-019-0828-7. Comprehensive overview of immune check point inhibitor–associated vasculitic manifestations that will become increasingly important for rheumatologists and immunologists in the future.

101.

Lidar M, Lipschitz N, Langevitz P, Shoenfeld Y. The infectious etiology of vasculitis. Autoimmunity. 2009;42(5):432–8. https://doi.org/10.1080/08916930802613210.CrossRefPubMed

102.

Haq SA, Pagnoux C. Infection-associated vasculitides. Int J Rheum Dis. 2019;22(Suppl 1):109–15. https://doi.org/10.1111/1756-185X.13287.CrossRefPubMed

103.

• Theofilis P, Vordoni A, Koukoulaki M, Vlachopanos G, Kalaitzidis RG. Overview of infections as an etiologic factor and complication in patients with vasculitides. Rheumatol Int. 2022;1–12. https://doi.org/10.1007/s00296-022-05100-9. Provides good explanation of mechanisms of infection-associated vasculitis and overview of well-studied infectious etiologies.

104.

Berti A, Moura MC, Sechi E, Squizzato F, Costanzo G, Chen JJ, Warrington KJ. Beyond giant cell arteritis and Takayasu’s arteritis: secondary large vessel vasculitis and vasculitis mimickers. Curr Rheumatol Rep. 2020;22(12):88. https://doi.org/10.1007/s11926-020-00965-w.CrossRefPubMed

105.

Pagnoux C, Cohen P, Guillevin L. Vasculitides secondary to infections. Clin Exp Rheumatol. 2006;24(2 Suppl 41):S71-81.PubMed

106.

• Younger DS, Coyle PK. Central nervous system vasculitis due to infection. Neurol Clin. 2019;37(2):441-463. https://doi.org/10.1016/j.ncl.2019.01.002. Comprehensive overview of infectious vasculitis of the central nervous system.

107.

Gauto AR, Cone LA, Woodard DR, Mahler RJ, Lynch RD, Stoltzman DH. Arterial infections due to Listeria monocytogenes: report of four cases and review of world literature. Clin Infect Dis. 1992;14(1):23–8. https://doi.org/10.1093/clinids/14.1.23.CrossRefPubMed

108.

Clouse WD, DeWitt CC, Hagino RT, DeCaprio J, Kashyap VS. Rapidly enlarging iliac aneurysm secondary to listeria monocytogenes infection: a case report. Vasc Endovascular Surg. 2003;37(2):145–9. https://doi.org/10.1177/153857440303700211.CrossRefPubMed

109.

Ahmed AOE, Babikir MMI, Khojali AEM, Arachchige SNM, Abdirahman AM, Mohamed MFH. Central nervous system vasculitis as a rare presentation of mycoplasma pneumoniae: a case report. Case Rep Neurol. 2020;12(3):402–9. https://doi.org/10.1159/000510632.CrossRefPubMedPubMedCentral

110.

Delaval L, Goulenok T, Achouh P, Saadoun D, Gaudric J, Pellenc Q, et al. New insights on tuberculous aortitis. J Vasc Surg. 2017;66(1):209–15. https://doi.org/10.1016/j.jvs.2016.11.045.CrossRefPubMed

111.

Roberts WC, Moore AJ, Roberts CS. Syphilitic aortitis: still a current common cause of aneurysm of the tubular portion of ascending aorta. Cardiovasc Pathol. 2020;46: 107175. https://doi.org/10.1016/j.carpath.2019.107175.CrossRefPubMed

112.

Paulo N, Cascarejo J, Vouga L. Syphilitic aneurysm of the ascending aorta. Interact Cardiovasc Thorac Surg. 2012;14(2):223–5. https://doi.org/10.1093/icvts/ivr067.CrossRefPubMed

113.

Smith JL, Israel CW, Harner RE. Syphilitic temporal arteritis. Arch Ophthalmol. 1967;78(3):284–8. https://doi.org/10.1001/archopht.1967.00980030286005.CrossRefPubMed

114.

De Brito T, Silva AMGD, Abreu PAE. Pathology and pathogenesis of human leptospirosis: a commented review. Rev Inst Med Trop Sao Paulo. 2018;60: e23. https://doi.org/10.1590/s1678-9946201860023.CrossRefPubMedPubMedCentral

115.

Gardini G, Zanotti P, Pucci A, Tomasoni L, Caligaris S, Paro B, et al. Non-typhoidal Salmonella aortitis. Infection. 2019;47(6):1059–63. https://doi.org/10.1007/s15010-019-01344-z.CrossRefPubMed

116.

de Worm S, Giot JB, Courtoy C, Gillet E, Amrane S, Huynen P, et al. A case of giant cell arteritis associated with culture-proven Coxiella burnetii aortitis. Int J Infect Dis. 2018;69:50–4. https://doi.org/10.1016/j.ijid.2018.01.028.CrossRefPubMed

117.

Odeh M, Oliven A. Temporal arteritis associated with acute Q fever. A case report. Angiology. 1994;45(12):1053–7. https://doi.org/10.1177/000331979404501209.CrossRefPubMed

118.

Lefebvre M, Grossi O, Agard C, Perret C, Le Pape P, Raoult D, Hamidou MA. Systemic immune presentations of Coxiella burnetii infection (Q Fever). Semin Arthritis Rheum. 2010;39(5):405–9. https://doi.org/10.1016/j.semarthrit.2008.10.004.CrossRefPubMed

119.

Cascio A, Iaria C. Brucella aortitis: an underdiagnosed and under-reported disease. Int J Rheum Dis. 2014;17(7):825. https://doi.org/10.1111/1756-185X.12449.CrossRefPubMed

120.

Turkoglu SA, Halicioglu S, Sirmatel F, Yildiz M, Yildiz N, Yildiz S. Vasculitis and neurobrucellosis: Evaluation of nine cases using radiologic findings. Brain Behav. 2018;8(4): e00947. https://doi.org/10.1002/brb3.947.CrossRefPubMedPubMedCentral

121.

Briere M, Kaladji A, Douane F, Breux JP, Touroult-Jupin P, Boisset S, et al. Francisella tularensis aortitis. Infection. 2016;44(2):263–5. https://doi.org/10.1007/s15010-015-0824-4.CrossRefPubMed

122.

Nagel MA, Cohrs RJ, Mahalingam R, Wellish MC, Forghani B, Schiller A, et al. The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology. 2008;70(11):853–60. https://doi.org/10.1212/01.wnl.0000304747.38502.e8.CrossRefPubMed

123.

Hauer L, Pikija S, Schulte EC, Sztriha LK, Nardone R, Sellner J. Cerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review. J Neuroinflammation. 2019;16(1):19. https://doi.org/10.1186/s12974-019-1409-4.CrossRefPubMedPubMedCentral

124.

Fan TH, Khoury J, Cho SM, Bhimraj A, Shoskes A, Uchino K. Cerebrovascular complications and vasculopathy in patients with herpes simplex virus central nervous system infection. J Neurol Sci. 2020;419: 117200. https://doi.org/10.1016/j.jns.2020.117200.CrossRefPubMed

125.

Kouchi M, Sato S, Kamono M, Taoda A, Iijima K, Mizuma A, et al. A case of polyarteritis nodosa associated with cytomegalovirus infection. Case Rep Rheumatol. 2014;2014: 604874. https://doi.org/10.1155/2014/604874.CrossRefPubMedPubMedCentral

126.

Abadeer K, Aslam N, Cortese C, Wadei HM. Cytomegalovirus-induced polyarteritis nodosa in a liver transplant recipient. Am J Transplant. 2017;17(12):3236–40. https://doi.org/10.1111/ajt.14376.CrossRefPubMed

127.

Vega LE, Espinoza LR. Vasculitides in HIV infection. Curr Rheumatol Rep. 2020;22(10):60. https://doi.org/10.1007/s11926-020-00945-0.CrossRefPubMedPubMedCentral

128.

Brand M, Woodiwiss AJ, Michel F, Nayler S, Veller MG, Norton GR. Large vessel adventitial vasculitis characterizes patients with critical lower limb ischemia with as compared to without human immunodeficiency virus infection. PLoS ONE. 2014;9(8): e106205. https://doi.org/10.1371/journal.pone.0106205.CrossRefPubMedPubMedCentral

129.

Guillevin L. Infections in vasculitis. Best Pract Res Clin Rheumatol. 2013;27(1):19–31. https://doi.org/10.1016/j.berh.2013.01.004.CrossRefPubMed

130.

Wang CR, Tsai HW. Human hepatitis viruses-associated cutaneous and systemic vasculitis. World J Gastroenterol. 2021;27(1):19–36. https://doi.org/10.3748/wjg.v27.i1.19.CrossRefPubMedPubMedCentral

131.

Zeller V, Lortholary O. Vascularites secondaires aux infections fongiques [Vasculitis secondary to fungal infections]. Presse Med. 2004;33(19 Pt 2):1385–8. French. https://doi.org/10.1016/s0755-4982(04)98937-3.

132.

Huang J, Cano EJ, Shweta F, Shah AS, Schuetz AN, Bois M, Gurram PR. Infected aneurysm of the native aorta due to Coccidioides posadasii. Open Forum Infect Dis. 2021;8(6):ofab266. https://doi.org/10.1093/ofid/ofab266.

133.

Brunner S, Engelmann MG, Näbauer M. Thoracic mycotic pseudoaneurysm from Candida albicans infection. Eur Heart J. 2008;29(12):1515. https://doi.org/10.1093/eurheartj/ehm623.CrossRefPubMed

134.

Roberts M, Carmichael A, Martin P. Cerebral vasculitis caused by Aspergillus species in an immunocompetent adult. Infection. 2004;32(6):360–3. https://doi.org/10.1007/s15010-004-3077-1.CrossRefPubMed

135.

Varghese B, Ting K, Lopez-Mattei J, Iliescu C, Kim J, Kim P. Aspergillus endocarditis of the mitral valve with ventricular myocardial invasion, cerebral vasculitis, and intracranial mycotic aneurysm formation in a patient with hemophagocytic lymphohistiocytosis. Med Mycol Case Rep. 2018;21:49–51. https://doi.org/10.1016/j.mmcr.2018.05.001.CrossRefPubMedPubMedCentral

136.

Marquez JM, Arauz A. Cerebrovascular complications of neurocysticercosis. Neurologist. 2012;18(1):17–22. https://doi.org/10.1097/NRL.0b013e31823d7a80.CrossRefPubMed

137.

Meliou M, Mavridis IN, Pyrgelis ES, Agapiou E. Toxocariasis of the nervous system. Acta Parasitol. 2020;65(2):291–9. https://doi.org/10.2478/s11686-019-00166-1.CrossRefPubMed

138.

Depascale R, Pizzi M, Padoan R. Whipple’s aortitis. Rheumatology (Oxford). 2022;keac042. https://doi.org/10.1093/rheumatology/keac042.

139.

Guillevin L. Vasculitides in the context of HIV infection. AIDS. 2008;22(Suppl 3):S27-33. https://doi.org/10.1097/01.aids.0000327513.53255.17.CrossRefPubMed

140.

Abendroth A, Slobedman B. Varicella-zoster virus and giant cell arteritis. J Infect Dis. 2021;223(1):4–6. https://doi.org/10.1093/infdis/jiaa567.CrossRefPubMed

141.

Kang R, Tanaka TD, Ogasawara Y, Yoshimura M. A rare complication of chronic active Epstein-Barr virus infection. JACC Case Rep. 2020;2(5):756–9. https://doi.org/10.1016/j.jaccas.2020.03.022.CrossRefPubMedPubMedCentral

142.

Jamal O, Sahel N, Saouab R, El Qatni M, Zaizaa M, El Kassimi I, et al. Fatal systemic vasculitis associated with chronic active Epstein-Barr virus infection. Mo Med. 2021;118(3):226–32.PubMedPubMedCentral

143.

Douvoyiannis M, Litman N, Goldman DL. Neurologic manifestations associated with parvovirus B19 infection. Clin Infect Dis. 2009;48(12):1713–23. https://doi.org/10.1086/599042.CrossRefPubMed

144.

Patel P, DeCuir J, Abrams J, Campbell AP, Godfred-Cato S, Belay ED. Clinical characteristics of multisystem inflammatory syndrome in adults: a systematic review. JAMA Netw Open. 2021;4(9): e2126456. https://doi.org/10.1001/jamanetworkopen.2021.26456.CrossRefPubMedPubMedCentral

145.

Becker RC. COVID-19-associated vasculitis and vasculopathy. J Thromb Thrombolysis. 2020;50(3):499–511. https://doi.org/10.1007/s11239-020-02230-4.CrossRefPubMedPubMedCentral

146.

Oda R, Inagaki T, Ishikane M, Hotta M, Shimomura A, Sato M, et al. Case of adult large vessel vasculitis after SARS-CoV-2 infection. Ann Rheum Dis. 2020;annrheumdis-2020–218440. https://doi.org/10.1136/annrheumdis-2020-218440.

147.

Dhakal P, Khadka S, Clowes JA, Chakinala RC. Aortitis in COVID-19. IDCases. 2021;24: e01063. https://doi.org/10.1016/j.idcr.2021.e01063.CrossRefPubMedPubMedCentral

148.

Manenti A, Farinetti A, Manco G, Mattioli A. Vasculitis and aortitis: COVID-19 challenging complications. J Vasc Surg. 2021;73(1):347–8. https://doi.org/10.1016/j.jvs.2020.08.029.CrossRefPubMed

149.

Harroud A, Almutlaq A, Pellerin D, Paz D, Linnell GJ, Gendron D. West Nile virus-associated vasculitis and intracranial hemorrhage. Neurol Neuroimmunol Neuroinflamm. 2019;7(1): e641. https://doi.org/10.1212/NXI.0000000000000641.CrossRefPubMedPubMedCentral

Title: Spectrum of Large- and Medium-Vessel Vasculitis in Adults: Neoplastic, Infectious, Drug-Induced, Autoinflammatory, and Primary Immunodeficiency Diseases
Authors: Fabian Lötscher
Roxana Pop
Pascal Seitz
Mike Recher
Luca Seitz
Publication date: 03-08-2022
Publisher: Springer US
Keywords: Primary Immunodeficiency
Vasculitis
Vasculitis
Chronic Inflammatory Bowel Disease
Takayasu's Arteriitis
Takayasu's Arteriitis
Familial Mediterranean Fever
Published in: Current Rheumatology Reports / Issue 10/2022
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-022-01083-5

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