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World Journal of Surgical Oncology

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Open Access 01-12-2013 | Research

Preventive effect of ulinastatin on postoperative complications, immunosuppression, and recurrence in esophagectomy patients

Authors: Lingmin Zhang, Ning Wang, Suna Zhou, Wenguang Ye, Qinglin Yao, Guixia Jing, Mingxin Zhang

Published in: World Journal of Surgical Oncology | Issue 1/2013

Abstract

Background

To evaluate the potential efficacy of preventive effect of ulinastatin in esophagectomy patients.

Methods

Eighty patients with esophageal cancer were preoperatively allocated at random into two equal groups. Ulinastatin was administered to the treatment group (U) whereas the control group (C) received a placebo. The arterial oxygen tension and carbon dioxide tension were measured and the respiratory index (RI) was calculated. Plasma levels of circulating T lymphocyte subsets and interleukin 6 (IL-6) were measured and clinical courses of patients in the two groups were compared.

Results

RI in the U group was significantly lower than that in the C group. The rate of postoperative complications and the duration of ICU stay were significantly lower in the U group. Ulinastatin significantly increased the rate of CD3⁺ and CD4⁺ cells, and ratio of CD4⁺/CD8⁺, but decreased the rate of CD8⁺ cells and release of IL-6 compared to the C group on postoperative days 1 and 3. Patients within the C group showed worse recurrence free survival. Multivariate analysis revealed that ulinastatin administration significantly decreased the incidence of recurrence.

Conclusions

Ulinastatin had a preventive effect on postoperative complications and immunosuppression in esophagectomy patients, thereby prolongingrecurrence free survival.

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Title: Preventive effect of ulinastatin on postoperative complications, immunosuppression, and recurrence in esophagectomy patients
Authors: Lingmin Zhang
Ning Wang
Suna Zhou
Wenguang Ye
Qinglin Yao
Guixia Jing
Mingxin Zhang
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2013
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-11-84

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Preventive effect of ulinastatin on postoperative complications, immunosuppression, and recurrence in esophagectomy patients

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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