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BMC Pediatrics
Published in: BMC Pediatrics 1/2020

01-12-2020 | Research article

Prevalence of neonatal hypothermia and its associated factors in East Africa: a systematic review and meta-analysis

Authors: Biruk Beletew, Ayelign Mengesha, Mesfin Wudu, Melese Abate

Published in: BMC Pediatrics | Issue 1/2020

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Abstract

Background

Neonatal hypothermia is a global health problem and a major factor for neonatal morbidity and mortality, especially in low and middle-income countries. Therefore, this systematic review and meta-analysis aimed to assess the prevalence of neonatal hypothermia and its associated factors in Eastern Africa.

Methods

We used the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines to search electronic databases (PubMed, Cochrane Library and Google Scholar; date of last search: 15 October 2019) for studies reporting the prevalence and associated factors of neonatal hypothermia. The data was extracted in the excel sheet considering prevalence, and categories of associated factors reported. A weighted inverse variance random-effects model was used to estimate the magnitude and the effect size of factors associated with hypothermia. The subgroup analysis was done by country, year of publication, and study design.

Results

A total of 12 potential studies with 20,911 participants were used for the analysis. The pooled prevalence of neonatal hypothermia in East Africa was found to be 57.2% (95%CI; 39.5–75.0). Delay in initiation of breastfeeding (adjusted Odds Ratio(aOR) = 2.83; 95% CI: 1.40–4.26), having neonatal health problem (aOR = 2.68; 95% CI: 1.21–4.15), being low birth weight (aOR =2.16; 95%CI: 1.03–3.29), being preterm(aOR = 4.01; 95%CI: 3.02–5.00), and nighttime delivery (aOR = 4.01; 95% CI:3.02–5.00) were identified associated factors which significantly raises the risk of neonatal hypothermia.

Conclusions

The prevalence of neonatal hypothermia in Eastern Africa remains high. Delay in initiation of breastfeeding, having a neonatal health problem, being low birth weight, preterm, and nighttime delivery were identified associated factors that significantly raises the risk of neonatal hypothermia.
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Literature
1.
World Health Organization (WHO). Thermal control of the newborn: a practical guide. Geneva: World Health Organization; 1993.
2.
Dragovich D, Tamburlini G, Alisjahbana A, Kambarami R, Karagulova J, Lincetto O, et al. Thermal control of the newborn: knowledge and practice of health professionals in seven countries. Acta Paediatr. 1997;86(6):645–50.CrossRef
3.
Onalo R. Neonatal hypothermia in sub-Saharan Africa: a review. Niger J Clin Pract. 2013;16(2):129–38.CrossRef
4.
Lunze K, Bloom DE, Jamison DT, Hamer DH. The global burden of neonatal hypothermia: systematic review of a major challenge for newborn survival. BMC Med. 2013;11(1):24.CrossRef
5.
Mullany LC, Katz J, Khatry SK, LeClerq SC, Darmstadt GL, Tielsch JM. Neonatal hypothermia and associated risk factors among newborns of southern Nepal. BMC Med. 2010;8(1):43.CrossRef
6.
Mullany LC, Katz J, Khatry SK, LeClerq SC, Darmstadt GL, Tielsch JM. Risk of mortality associated with neonatal hypothermia in southern Nepal. Arch Pediatr Adolesc Med. 2010;164(7):650–6.CrossRef
7.
Sodemann M, Nielsen J, Veirum J, Jakobsen MS, Biai S, Aaby P. Hypothermia of newborns is associated with excess mortality in the first 2 months of life in Guinea-Bissau, West Africa. Tropical Med Int Health. 2008;13(8):980–6.CrossRef
8.
Kumar V, Shearer J, Kumar A, Darmstadt G. Neonatal hypothermia in low resource settings: a review. J Perinatol. 2009;29(6):401.CrossRef
9.
Lawn Je O, Adler A, Cousens S. Europe Funders Group. Four million neonatal deaths: counting and attribution of cause of death. Paediatr Perinat Epidemiol. 2012;22(5):2012.
10.
Demissie BW, Abera BB, Chichiabellu TY, Astawesegn FH. Neonatal hypothermia and associated factors among neonates admitted to neonatal intensive care unit of public hospitals in Addis Ababa. Ethiopia BMC Pediatr. 2018;18(1):263.CrossRef
11.
CSA-Ethiopia I. International: Ethiopia Demographic and Health Survey 2011, vol. 2012. Addis Ababa, Ethiopia and Calverton, Maryland, USA: Central statistical Agency of Ethiopia and ICF international.
12.
Manani M, Jegatheesan P, DeSandre G, Song D, Showalter L, Govindaswami B. Elimination of admission hypothermia in preterm very low-birth-weight infants by standardization of delivery room management. Permanente J. 2013;17(3):8.CrossRef
13.
Ogunlesi TA, Ogunfowora OB, Ogundeyi MM. Prevalence and risk factors for hypothermia on admission in Nigerian babies< 72 h of age. J Perinat Med. 2009;37(2):180–4.CrossRef
14.
Byaruhanga R, Bergstrom A, Okong P. Neonatal hypothermia in Uganda: prevalence and risk factors. J Trop Pediatr. 2005;51(4):212–5.CrossRef
15.
Karsten Lunze DEB, Dean T Jamison and Davidson H Hamer. The global burden of neonatal hypothermia:systematic review of a major challenge fornewborn survival. BMC Medicine. 2013.
16.
Lucia Hug MA, Danzhen You, Leontine Alkema, on behalf of the UN Inter-agency Group for Child Mortality Estimation. National, regional, and global levels and trends in neonatal mortality between 1990 and 2017, with scenario-based projections to 2030: a systematic analysis. 2017.
17.
Mullany LC, editor Neonatal hypothermia in low-resource settings. Seminars in perinatology; United state: Elsevier.
18.
Mekonnen T, Tenu T, Aklilu T, Abera T. Assessment of neonatal death and causes among admitted neonates in neonatal intensive care unit of Mizan Tepi University teaching hospital, bench Maji zone, south-West Ethiopia, 2018. Clinics Mother Child Health. 2018;15(305):2.
19.
Markos Y, Dadi AF, Demisse AG, Ayanaw Habitu Y, Derseh BT, Debalkie G. Determinants of under-five pneumonia at Gondar University hospital, Northwest Ethiopia: an unmatched case-control study. J Environ Public Health. 2019;2019.
20.
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.CrossRef
21.
Hailu F. Assessement of traditional medicine utilization for children and associated factors among parents in Tole Woreda, southwest Shoa, Oromia, Ethiopia, 2017: Addis Ababa university; 2017.
22.
Bergström A, Byaruhanga R, Okong P. The impact of newborn bathing on the prevalence of neonatal hypothermia in Uganda: a randomized, controlled trial. Acta Paediatr. 2005;94(10):1462–7.CrossRef
23.
Mengesha HG, Sahle BW. Cause of neonatal deaths in northern Ethiopia: a prospective cohort study. BMC Public Health. 2017;17(1):62.CrossRef
24.
Demisse AG, Alemu F, Gizaw MA, Tigabu Z. Patterns of admission and factors associated with neonatal mortality among neonates admitted to the neonatal intensive care unit of University of Gondar Hospital, Northwest Ethiopia. Pediatric Health Med Ther. 2017;8:57.CrossRef
25.
Ukke GG, Diriba K. Prevalence and factors associated with neonatal hypothermia on admission to neonatal intensive care units in Southwest Ethiopia–a cross-sectional study. PLoS One. 2019;14(6):e0218020.CrossRef
26.
Ebrahim TSaE. Proportion of neonatal hypothermia and associated factors among new-borns at Gondar University teaching and Refferal hospital, Northwest Ethiopia: A Hospital Based Cross Sectional Study.
27.
Tasew H, Gebrekristos K, Kidanu K, Mariye T, Teklay G. Determinants of hypothermia on neonates admitted to the intensive care unit of public hospitals of central zone, Tigray, Ethiopia 2017: unmatched case–control study. BMC Res Notes. 2018;11(1):576.CrossRef
28.
Bayih WA, Assefa N, Dheresa M, Minuye B, Demis S. Neonatal hypothermia and associated factors within six hours of delivery in eastern part of Ethiopia: a cross-sectional study. BMC Pediatr. 2019;19(1):252.
29.
Talbert A, Atkinson S, Karisa J, Ignas J, Chesaro C, Maitland K. Hypothermia in children with severe malnutrition: low prevalence on the tropical coast of Kenya. J Trop Pediatr. 2009;55(6):413–6.CrossRef
30.
Switchenko N, Kibaru E, Fassl B. Prevalence of neonatal hypothermia in a referal hospitals newborn unit in Kenya; 2017.
31.
Ogunlesi TA, Ogunfowora OB, Adekanmbi FA, Fetuga BM, Olanrewaju DM. Point-of-admission hypothermia among high-risk Nigerian newborns. BMC Pediatr. 2008;8(1):40.CrossRef
32.
Fulton C. Improving neonatal mortality in an Ethiopian referral hospital. BMJ Open Quality. 2013;2(2):u202086. w1064.
33.
Seyum T, Ebrahim E. Proportion of neonatal hypothermia and associated factors among new-borns at Gondar University teaching and Refferal hospital, Northwest Ethiopia: a hospital based cross sectional study. General Medicine: Open Access 2015;2015.
34.
Farhadi R, Rezai MS, Nakhshab M. Incidence of neonatal hypothermia at birth in hospitals of Islamic Republic of Iran: a review. J Pediatr Rev. 2014;2(2):21–30.
35.
Akter S, Parvin R, Yasmeen BN. Admission hypothermia among neonates presented to neonatal intensive care unit. J Nepal Paediatr Society. 2013;33(3):166–71.CrossRef
36.
Ali SR, Mirza R, Qadir M, Ahmed S, Bhatti Z, Demas S. Neonatal hypothermia among hospitalized high risk newborns in a developing country; 2012.
37.
Thwala MD. The quality of neonatal inter-facility transport systems within the Johannesburg metropolitan region; 2012.
38.
Mullany LC, Katz J, Khatry SK, LeClerq SC, Darmstadt GL, Tielsch JM. Incidence and seasonality of hypothermia among newborns in southern Nepal. Arch Pediatr Adolesc Med. 2010;164(1):71–7.CrossRef
39.
Murthy S, Guddattu V, Edward L, NSN SL. Risk factors of neonatal sepsis in India: A systematic review and meta-analysis; 2019.
40.
Chan GJ Lee AC, Baqui AH, Tan J, Black RE. Risk of early-onset neonatal infection with maternal infection or colonization: a global systematic review and meta-analysis. 2013.
41.
Shruti MurthyID MAG, Vasudeva Guddattu ID, Edward L. Risk factors of neonatal sepsis in India: A systematic review and meta-analysis; 2019.
42.
Zayeri F, Kazemnejad A, Ganjali M, Babaei G, Nayeri F. Incidence and risk factors of neonatal hypothermia at referral hospitals in Tehran, Islamic Republic of Iran; 2007.CrossRef
43.
Gordon BA, Fletcher M, MacDonald G. Neonatology, pathophysiology and Management of the Newborn. Philadelphia: Lippincot Williams & Wilkins; 1999.
44.
Knobel RB. Thermal stability of the premature infant in neonatal intensive care. Newborn Infant Nurs Rev. 2014;14(2):72–6.CrossRef
45.
Smith ER, Hurt L, Chowdhury R, Sinha B, Fawzi W, Edmond KM, et al. Delayed breastfeeding initiation and infant survival: a systematic review and meta-analysis. PLoS One. 2017;12(7):e0180722.
46.
Smith ER, Locks LM, Manji KP, McDonald CM, Kupka R, Kisenge R, et al. Delayed breastfeeding initiation is associated with infant morbidity. J Pediatr. 2017;191:57–62. e2.
47.
Smith LR, Ranadip Chowdhury, Bireshwar Sinha, Wafaie Fawzi, Karen M Edmond. Delayed breastfeeding initiation and infant survival. Ethiopia: A systematicreviewandmeta-analysis.
Metadata
Title
Prevalence of neonatal hypothermia and its associated factors in East Africa: a systematic review and meta-analysis
Authors
Biruk Beletew
Ayelign Mengesha
Mesfin Wudu
Melese Abate
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2020
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-020-02024-w

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