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Diabetologia
Published in: Diabetologia 5/2011

01-05-2011 | Research Letter

Prevalence of monogenic diabetes in young adults: a community-based, cross-sectional study in Oxfordshire, UK

Authors: J. Kropff, M. P. Selwood, M. I. McCarthy, A. J. Farmer, K. R. Owen

Published in: Diabetologia | Issue 5/2011

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Excerpt

To the Editor: Recently, Shields and colleagues used cases ascertained from diagnostic genetic-testing referrals to estimate a minimum population prevalence for monogenic beta cell disorders (i.e. MODY) in the UK population [1]. They estimated a minimum prevalence of 108 cases of MODY per million, with half due to mutations in HNF1A-MODY. The study included all cases of MODY diagnosed through the UK testing laboratory over a 12 year period, but had the limitations of not being community-based and only included individuals who had been referred for molecular testing through secondary care. …
Literature
1.
Shields BM, Hicks S, Shepherd MH, Colclough K, Hattersley AT, Ellard S (2010) Maturity-onset diabetes of the young (MODY): how many cases are we missing? Diabetologia 53:2504–2508PubMedCrossRef
2.
Panzram G, Adolph W (1981) Heterogeneity of maturity onset diabetes at young age (MODY). Lancet 2:986PubMedCrossRef
3.
Ledermann HM (1995) Maturity-onset diabetes of the young (MODY) at least ten times more common in Europe than previously assumed? Diabetologia 38:1482PubMedCrossRef
4.
Schober E, Rami B, Grabert M et al (2009) Phenotypical aspects of maturity-onset diabetes of the young (MODY diabetes) in comparison with type 2 diabetes mellitus (T2DM) in children and adolescents: experience from a large multicentre database. Diabet Med 26:466–473PubMedCrossRef
5.
Eide SA, Raeder H, Johansson S et al (2008) Prevalence of HNF1A (MODY3) mutations in a Norwegian population (the HUNT2 Study). Diabet Med 25:775–781PubMedCrossRef
6.
Shepherd M, Sparkes AC, Hattersley AT (2001) Genetic testing in maturity onset diabetes of the young (MODY); a new challenge for the diabetic clinic. Pract Diabetes 18:16–21CrossRef
7.
Thanabalasingham G, Pal A, Farmer AJ, Ellard S, McCarthy MI, Owen KR (2010) Diabetologia 53(Suppl 1):S63 (abstract)
8.
Stone MA, Camosso-Stefinovic J, Wilkinson J, de Lusignan S, Hattersley AT, Khunti K (2009) Incorrect and incomplete coding and classification of diabetes: a systematic review. Diabet Med 27:491–497CrossRef
Metadata
Title
Prevalence of monogenic diabetes in young adults: a community-based, cross-sectional study in Oxfordshire, UK
Authors
J. Kropff
M. P. Selwood
M. I. McCarthy
A. J. Farmer
K. R. Owen
Publication date
01-05-2011
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 5/2011
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-011-2090-z

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