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01-07-2016 | Original Article

Preterm birth alters neonatal, functional rich club organization

Authors: Dustin Scheinost, Soo Hyun Kwon, Xilin Shen, Cheryl Lacadie, Karen C. Schneider, Feng Dai, Laura R. Ment, R. Todd Constable

Published in: Brain Structure and Function | Issue 6/2016

Abstract

Alterations in neural networks are associated with the cognitive difficulties of the prematurely born. Using functional magnetic resonance imaging, we analyzed functional connectivity for preterm (PT) and term neonates at term equivalent age. Specifically, we constructed whole-brain networks and examined rich club (RC) organization, a common construct among complex systems where important (or “rich”) nodes connect preferentially to other important nodes. Both PT and term neonates showed RC organization with PT neonates exhibiting significantly reduced connections between these RC nodes. Additionally, PT neonates showed evidence of weaker functional segregation. Our results suggest that PT birth is associated with fundamental changes of functional organization in the developing brain.

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Title: Preterm birth alters neonatal, functional rich club organization
Authors: Dustin Scheinost
Soo Hyun Kwon
Xilin Shen
Cheryl Lacadie
Karen C. Schneider
Feng Dai
Laura R. Ment
R. Todd Constable
Publication date: 01-07-2016
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 6/2016
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-015-1096-6

At a glance: The STEP trials

Springer Medicine

Preterm birth alters neonatal, functional rich club organization

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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