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European Journal of Clinical Microbiology & Infectious Diseases

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Open Access 01-02-2019 | Original Article

Presence of Toxoplasma gondii infection in brain as a potential cause of risky behavior: a report of 102 autopsy cases

Authors: Dorota Samojłowicz, Joanna Twarowska-Małczyńska, Aleksandra Borowska-Solonynko, Łukasz A. Poniatowski, Nipika Sharma, Mieszko Olczak

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 2/2019

Abstract

Toxoplasmosis was linked to impairment in brain function, encompassing a wide range of behavioral and neuropsychiatric changes. Currently, the precise localization of Toxoplasma gondii in the human brain is limited and the parasite DNA was not found in population-based screening of autopsy cases. The aim of proposed study was to identify the presence of parasite DNA within the brain and its association with risky behavior and alcohol consumption in postmortem examination. Preliminarily, 102 cases with certain circumstances of death at time of forensic autopsy was included. Due to high risk of bias, the females were excluded from the analysis and final study group consists 97 cases divided into three groups: risky behavior, inconclusively risky behavior, and control group. The obtained tissue samples for Nested PCR covered four regions of the brain: symmetric left/right and anterior/posterior horns of lateral ventricles comprising lining ependyma and hippocampus. The second type of material comprised blood evaluated for antibodies prevalence using ELISA and alcohol concentration using HS-GC-FID. Analysis demonstrated 16.5% prevalence concerning the parasite DNA presence in examined brain tissue samples without specific distribution and association with age at death or days after death until an autopsy was performed. Results have shown correlation between occurrence of risky behavior leading to death and higher proportions of positive parasite DNA presence within the brain. Correlation was not observed between parasite DNA presence and excessive alcohol consumption. Conducted screening demonstrated correlation between parasite DNA presence in the brain with risky behavior and provided new information on possible effects of latent toxoplasmosis.

Tenter AM, Heckeroth AR, Weiss LM (2000) Toxoplasma gondii: from animals to humans. Int J Parasitol 30(12–13):1217–1258. https://doi.org/10.1016/S0020-7519(00)00124-7 CrossRefPubMedPubMedCentral

Weiss LM, Dubey JP (2009) Toxoplasmosis: a history of clinical observations. Int J Parasitol 39(8):895–901. https://doi.org/10.1016/j.ijpara.2009.02.004 CrossRefPubMedPubMedCentral

Dubremetz JF, Lebrun M (2012) Virulence factors of Toxoplasma gondii. Microbes Infect 14(15):1403–1410. https://doi.org/10.1016/j.micinf.2012.09.005 CrossRefPubMed

Montoya JG, Liesenfeld O (2004) Toxoplasmosis. Lancet 363(9425):1965–1976. https://doi.org/10.1016/S0140-6736(04)16412-X CrossRefPubMed

Flegr J, Prandota J, Sovičková M, Israili ZH (2014) Toxoplasmosis--a global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries. PLoS One 9(3):e90203. https://doi.org/10.1371/journal.pone.0090203 CrossRefPubMedPubMedCentral

Robert-Gangneux F, Dardé ML (2012) Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev 25(2):264–296. https://doi.org/10.1128/CMR.05013-11 CrossRefPubMedPubMedCentral

Pappas G, Roussos N, Falagas ME (2009) Toxoplasmosis snapshots: global status of toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis. Int J Parasitol 39(12):1385–1394. https://doi.org/10.1016/j.ijpara.2009.04.003 CrossRefPubMed

Flegr J (2013) Influence of latent toxoplasma infection on human personality, physiology and morphology: pros and cons of the Toxoplasma-human model in studying the manipulation hypothesis. J Exp Biol 216(Pt 1):127–133. https://doi.org/10.1242/jeb.073635 CrossRefPubMed

Webster JP, McConkey GA (2010) Toxoplasma gondii-altered host behaviour: clues as to mechanism of action. Folia Parasitol (Praha) 57(2):95–104. https://doi.org/10.14411/fp.2010.012 CrossRef

10.

Sugden K, Moffitt TE, Pinto L, Poulton R, Williams BS, Caspi A (2016) Is Toxoplasma gondii infection related to brain and behavior impairments in humans? Evidence from a population-representative birth cohort. PLoS One 11(2):e0148435. https://doi.org/10.1371/journal.pone.0148435 CrossRefPubMedPubMedCentral

11.

Cook TB, Brenner LA, Cloninger CR, Langenberg P, Igbide A, Giegling I, Hartmann AM, Konte B, Friedl M, Brundin L, Groer MW, Can A, Rujescu D, Postolache TT (2015) “Latent” infection with toxoplasma gondii: association with trait aggression and impulsivity in healthy adults. J Psychiatr Res 60:87–94. https://doi.org/10.1016/j.jpsychires.2014.09.019 CrossRefPubMed

12.

Havlícek J, Gasová ZG, Smith AP, Zvára K, Flegr J (2001) Decrease of psychomotor performance in subjects with latent 'asymptomatic' toxoplasmosis. Parasitology 122(Pt 5):515–520. https://doi.org/10.1017/S0031182001007624 CrossRefPubMed

13.

Beste C, Getzmann S, Gajewski PD, Golka K, Falkenstein M (2014) Latent Toxoplasma gondii infection leads to deficits in goal-directed behavior in healthy elderly. Neurobiol Aging 35(5):1037–1044. https://doi.org/10.1016/j.neurobiolaging.2013.11.012 CrossRefPubMed

14.

Flegr J, Preiss M, Klose J, Havlícek J, Vitáková M, Kodym P (2003) Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii Dopamine, a missing link between schizophrenia and toxoplasmosis? Biol Psychol 63(3):253–268. https://doi.org/10.1016/S0301-0511(03)00075-9 CrossRefPubMed

15.

Lester D (2010) Brain parasites and suicide. Psychol Rep 107(2):424. https://doi.org/10.2466/12.13.PR0.107.5.424 CrossRefPubMed

16.

Lester D (2012) Toxoplasma gondii and homicide. Psychol Rep 111(1):196–197. https://doi.org/10.2466/12.15.16.PR0.111.4.196-197

17.

Torrey EF, Bartko JJ, Yolken RH (2012) Toxoplasma gondii and other risk factors for schizophrenia: an update. Schizophr Bull 38(3):642–647. https://doi.org/10.1093/schbul/sbs043 CrossRefPubMedPubMedCentral

18.

Markovitz AA, Simanek AM, Yolken RH, Galea S, Koenen KC, Chen S, Aiello AE (2015) Toxoplasma gondii and anxiety disorders in a community-based sample. Brain Behav Immun 43:192–197. https://doi.org/10.1016/j.bbi.2014.08.001 CrossRefPubMed

19.

Blader IJ, Saeij JP (2009) Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence. APMIS 117(5–6):458–476. https://doi.org/10.1111/j.1600-0463.2009.02453.x CrossRefPubMedPubMedCentral

20.

Hermes G, Ajioka JW, Kelly KA, Mui E, Roberts F, Kasza K, Mayr T, Kirisits MJ, Wollmann R, Ferguson DJ, Roberts CW, Hwang JH, Trendler T, Kennan RP, Suzuki Y, Reardon C, Hickey WF, Chen L, McLeod R (2008) Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. J Neuroinflammation 5:48. https://doi.org/10.1186/1742-2094-5-48 CrossRefPubMedPubMedCentral

21.

Jaber M, Robinson SW, Missale C, Caron MG (1996) Dopamine receptors and brain function. Neuropharmacology 35(11):1503–1519. https://doi.org/10.1016/S0028-3908(96)00100-1 CrossRefPubMed

22.

Nieoullon A (2002) Dopamine and the regulation of cognition and attention. Prog Neurobiol 67(1):53–83. https://doi.org/10.1016/S0301-0082(02)00011-4 CrossRefPubMed

23.

Prandovszky E, Gaskell E, Martin H, Dubey JP, Webster JP, McConkey GA (2011) The neurotropic parasite toxoplasma gondii increases dopamine metabolism. PLoS One 6(9):e23866. https://doi.org/10.1371/journal.pone.0023866 CrossRefPubMedPubMedCentral

24.

Coombes JL, Charsar BA, Han SJ, Halkias J, Chan SW, Koshy AA, Striepen B, Robey EA (2013) Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread. Proc Natl Acad Sci U S A 110(21):E1913–E1922. https://doi.org/10.1073/pnas.1220272110 CrossRefPubMedPubMedCentral

25.

Watanabe PDS, Trevizan AR, Silva-Filho SE, Góis MB, Garcia JL, Cuman RKN, Breithaupt-Faloppa AC, Sant Ana DMG, Nogueira de Melo GA (2018) Immunocompetent host develops mild intestinal inflammation in acute infection with Toxoplasma gondii. PLoS One 13(1):e0190155. https://doi.org/10.1371/journal.pone.0190155 CrossRefPubMedPubMedCentral

26.

Carruthers VB, Suzuki Y (2007) Effects of Toxoplasma gondii infection on the brain. Schizophr Bull 33(3):745–751. https://doi.org/10.1093/schbul/sbm026 CrossRefPubMedPubMedCentral

27.

Hsu PC, Groer M, Beckie T (2014) New findings: depression, suicide, and Toxoplasma gondii infection. J Am Assoc Nurse Pract 26(11):629–637. https://doi.org/10.1002/2327-6924.12129 CrossRefPubMed

28.

Vyas A, Kim SK, Giacomini N, Boothroyd JC, Sapolsky RM (2007) Behavioral changes induced by toxoplasma infection of rodents are highly specific to aversion of cat odors. Proc Natl Acad Sci U S A 104(15):6442–6447. https://doi.org/10.1073/pnas.0608310104 CrossRefPubMedPubMedCentral

29.

Berenreiterová M, Flegr J, Kuběna AA, Němec P (2011) The distribution of Toxoplasma gondii cysts in the brain of a mouse with latent toxoplasmosis: implications for the behavioral manipulation hypothesis. PLoS One 6(12):e28925. https://doi.org/10.1371/journal.pone.0028925 CrossRefPubMedPubMedCentral

30.

Conejero-Goldberg C, Torrey EF, Yolken RH (2003) Herpesviruses and toxoplasma gondii in orbital frontal cortex of psychiatric patients. Schizophr Res 60(1):65–69. https://doi.org/10.1016/S0920-9964(02)00160-3 CrossRefPubMed

31.

Homan WL, Vercammen M, De Braekeleer J, Verschueren H (2000) Identification of a 200- to 300-fold repetitive 529 bp DNA fragment in toxoplasma gondii, and its use for diagnostic and quantitative PCR. Int J Parasitol 30(1):69–75. https://doi.org/10.1016/S0020-7519(99)00170-8 CrossRefPubMed

32.

Furtado JM, Smith JR, Belfort R Jr, Gattey D, Winthrop KL (2011) Toxoplasmosis: a global threat. J Glob Infect Dis 3(3):281–284. https://doi.org/10.4103/0974-777X.83536 CrossRefPubMedPubMedCentral

33.

Turner M, Lenhart S, Rosenthal B, Zhao X (2013) Modeling effective transmission pathways and control of the world’s most successful parasite. Theor Popul Biol 86:50–61. https://doi.org/10.1016/j.tpb.2013.04.001 CrossRefPubMed

34.

Sa Q, Ochiai E, Tiwari A, Mullins J, Shastri N, Mercier C, Cesbron-Delauw MF, Suzuki Y (2017) Determination of a key antigen for immunological intervention to target the latent stage of Toxoplasma gondii. J Immunol 198(11):4425–4434. https://doi.org/10.4049/jimmunol.1700062 CrossRefPubMed

35.

Mendez OA, Koshy AA (2017) Toxoplasma gondii: entry, association, and physiological influence on the central nervous system. PLoS Pathog 13(7):e1006351. https://doi.org/10.1371/journal.ppat.1006351 CrossRefPubMedPubMedCentral

36.

Remington JS, Cavanaugh EN (1965) Isolation of the encysted form of toxoplasma gondii from human skeletal muscle and brain. N Engl J Med 273(24):1308–1310. https://doi.org/10.1056/NEJM196512092732404 CrossRefPubMed

37.

Lang W, Miklossy J, Deruaz JP, Pizzolato GP, Probst A, Schaffner T, Gessaga E, Kleihues P (1989) Neuropathology of the acquired immune deficiency syndrome (AIDS): a report of 135 consecutive autopsy cases from Switzerland. Acta Neuropathol 77(4):379–390. https://doi.org/10.1007/BF00687372 CrossRefPubMed

38.

Strittmatter C, Lang W, Wiestler OD, Kleihues P (1992) The changing pattern of human immunodeficiency virus-associated cerebral toxoplasmosis: a study of 46 postmortem cases. Acta Neuropathol 83(5):475–481. https://doi.org/10.1007/BF00310023 CrossRefPubMed

39.

Laing RB, Flegg PJ, Brettle RP, Leen CL, Burns SM (1996) Clinical features, outcome and survival from cerebral toxoplasmosis in Edinburgh AIDS patients. Int J STD AIDS 7(4):258–264. https://doi.org/10.1258/0956462961917933 CrossRefPubMed

40.

Gajewski PD, Falkenstein M, Hengstler JG, Golka K (2014) Toxoplasma gondii impairs memory in infected seniors. Brain Behav Immun 36:193–199. https://doi.org/10.1016/j.bbi.2013.11.019 CrossRefPubMed

41.

Horacek J, Flegr J, Tintera J, Verebova K, Spaniel F, Novak T, Brunovsky M, Bubenikova-Valesova V, Holub D, Palenicek T, Höschl C (2012) Latent toxoplasmosis reduces gray matter density in schizophrenia but not in controls: voxel-based-morphometry (VBM) study. World J Biol Psychiatry 13(7):501–509. https://doi.org/10.3109/15622975.2011.573809 CrossRefPubMed

42.

Lafferty KD (2006) Can the common brain parasite, Toxoplasma gondii, influence human culture? Proc Biol Sci 273(1602):2749–2755. https://doi.org/10.1098/rspb.2006.3641 CrossRefPubMedPubMedCentral

43.

Vyas A (2015) Mechanisms of host behavioral change in Toxoplasma gondii rodent association. PLoS Pathog 11(7):e1004935. https://doi.org/10.1371/journal.ppat.1004935 CrossRefPubMedPubMedCentral

44.

Schlüter D, Kaefer N, Hof H, Wiestler OD, Deckert-Schlüter M (1997) Expression pattern and cellular origin of cytokines in the normal and toxoplasma gondii-infected murine brain. Am J Pathol 150(3):1021–1035PubMedPubMedCentral

45.

Hwang YS, Shin JH, Yang JP, Jung BK, Lee SH, Shin EH (2018) Characteristics of infection immunity regulated by toxoplasma gondii to maintain chronic infection in the brain. Front Immunol 9(158). https://doi.org/10.3389/fimmu.2018.00158

46.

Dantzer R, O'Connor JC, Lawson MA, Kelley KW (2011) Inflammation-associated depression: from serotonin to kynurenine. Psychoneuroendocrinology 36(3):426–436. https://doi.org/10.1016/j.psyneuen.2010.09.012 CrossRefPubMed

47.

Jeon SW, Kim YK (2017) Inflammation-induced depression: its pathophysiology and therapeutic implications. J Neuroimmunol 313:92–98. https://doi.org/10.1016/j.jneuroim.2017.10.016 CrossRefPubMed

48.

Fatokun AA, Hunt NH, Ball HJ (2013) Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease. Amino Acids 45(6):1319–1329. https://doi.org/10.1007/s00726-013-1602-1 CrossRefPubMed

49.

Xiao J, Li Y, Prandovszky E, Karuppagounder SS, Talbot CCJ, Dawson VL, Dawson TM, Yolken RH (2014) MicroRNA-132 dysregulation in toxoplasma gondii infection has implications for dopamine signaling pathway. Neuroscience 268:128–138. https://doi.org/10.1016/j.neuroscience.2014.03.015 CrossRefPubMed

50.

Jentsch JD, Roth RH, Taylor JR (2000) Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action. Prog Brain Res 126:433–453. https://doi.org/10.1016/S0079-6123(00)26028-7 CrossRefPubMed

51.

Stibbs HH (1985) Changes in brain concentrations of catecholamines and indoleamines in Toxoplasma gondii infected mice. Ann Trop Med Parasitol 79(2):153–157. https://doi.org/10.1080/00034983.1985.11811902 CrossRefPubMed

52.

Skallová A, Novotná M, Kolbeková P, Gasová Z, Veselý V, Sechovská M, Flegr J (2005) Decreased level of novelty seeking in blood donors infected with Toxoplasma. Neuro Endocrinol Lett 26(5):480–486PubMed

53.

Martin HL, Alsaady I, Howell G, Prandovszky E, Peers C, Robinson P, McConkey GA (2015) Effect of parasitic infection on dopamine biosynthesis in dopaminergic cells. Neuroscience 306:50–62. https://doi.org/10.1016/j.neuroscience.2015.08.005 CrossRefPubMed

54.

Novotná M, Hanusova J, Klose J, Preiss M, Havlicek J, Roubalová K, Flegr J (2005) Probable neuroimmunological link between Toxoplasma and cytomegalovirus infections and personality changes in the human host. BMC Infect Dis 5(54). https://doi.org/10.1186/1471-2334-5-54

55.

Gaskell EA, Smith JE, Pinney JW, Westhead DR, McConkey GA (2009) A unique dual activity amino acid hydroxylase in Toxoplasma gondii. PLoS One 4(3):e4801. https://doi.org/10.1371/journal.pone.0004801 CrossRefPubMedPubMedCentral

56.

McConkey GA, Martin HL, Bristow GC, Webster JP (2013) Toxoplasma gondii infection and behaviour - location, location, location? J Exp Biol 216(Pt 1):113–119. https://doi.org/10.1242/jeb.074153 CrossRefPubMedPubMedCentral

57.

Kitahama K, Geffard M, Araneda S, Arai R, Ogawa K, Nagatsu I, Pequignot JM (2007) Localization of L-DOPA uptake and decarboxylating neuronal structures in the cat brain using dopamine immunohistochemistry. Brain Res 1167:56–70. https://doi.org/10.1016/j.brainres.2007.05.081 CrossRefPubMed

58.

Flegr J, Havlícek J, Kodym P, Malý M, Smahel Z (2002) Increased risk of traffic accidents in subjects with latent toxoplasmosis: a retrospective case-control study. BMC Infect Dis 2(11). https://doi.org/10.1186/1471-2334-2-11

59.

Kocazeybek B, Oner YA, Turksoy R, Babur C, Cakan H, Sahip N, Unal A, Ozaslan A, Kilic S, Saribas S, Aslan M, Taylan A, Koc S, Dirican A, Uner HB, Oz V, Ertekin C, Kucukbasmaci O, Torun MM (2009) Higher prevalence of toxoplasmosis in victims of traffic accidents suggest increased risk of traffic accident in toxoplasma-infected inhabitants of Istanbul and its suburbs. Forensic Sci Int 187(1–3):103–108. https://doi.org/10.1016/j.forsciint.2009.03.007 CrossRefPubMed

60.

Fridstrøm L, Ifver J, Ingebrigtsen S, Kulmala R, Thomsen LK (1995) Measuring the contribution of randomness, exposure, weather, and daylight to the variation in road accident counts. Accid Anal Prev 27(1):1–20. https://doi.org/10.1016/0001-4575(94)E0023-E CrossRefPubMed

61.

Goniewicz K, Goniewicz M, Pawłowski W, Fiedor P (2016) Road accident rates: strategies and programmes for improving road traffic safety. Eur J Trauma Emerg Surg 42(4):433–438. https://doi.org/10.1007/s00068-015-0544-6 CrossRefPubMed

62.

Nordfjærn T, Şimşekoğlu Ö, Rundmo T (2014) Culture related to road traffic safety: a comparison of eight countries using two conceptualizations of culture. Accid Anal Prev 62:319–328. https://doi.org/10.1016/j.aap.2013.10.018 CrossRefPubMed

63.

Samojłowicz D, Borowska-Solonynko A, Kruczyk M (2017) New, previously unreported correlations between latent Toxoplasma gondii infection and excessive ethanol consumption. Forensic Sci Int 280:49–54. https://doi.org/10.1016/j.forsciint.2017.09.009 CrossRefPubMed

64.

Schmitz HP (2016) The global health network on alcohol control: successes and limits of evidence-based advocacy. Health Policy Plan 31(Suppl 1):i87–i97. https://doi.org/10.1093/heapol/czu064 CrossRefPubMed

65.

Parry C, Ferreira-Borges C, Poznyak V, Lönnroth K, Rehm J (2013) The international study on alcohol and infectious diseases: three priorities for research. Addiction 108(1):1–2. https://doi.org/10.1111/j.1360-0443.2012.04000.x CrossRefPubMed

66.

Shojania KG, Burton EC, McDonald KM, Goldman L (2003) Changes in rates of autopsy-detected diagnostic errors over time: a systematic review. JAMA 289(21):2849–2856. https://doi.org/10.1001/jama.289.21.2849 CrossRefPubMed

67.

Montoya JG (2002) Laboratory diagnosis of toxoplasma gondii infection and toxoplasmosis. J Infect Dis 185(Suppl 1):S73–S82. https://doi.org/10.1086/338827 CrossRefPubMed

68.

Flegr J (2013) How and why toxoplasma makes us crazy. Trends Parasitol 29(4):156–163 https://doi.org/10.1016/j.pt.2013.01.007 CrossRefPubMed

69.

Yagmur F, Yazar S, Temel HO, Cavusoglu M (2010) May Toxoplasma gondii increase suicide attempt-preliminary results in Turkish subjects? Forensic Sci Int 199(1–3):15–17. https://doi.org/10.1016/j.forsciint.2010.02.020 CrossRefPubMed

70.

Alvarado-Esquivel C, Pacheco-Vega SJ, Hernández-Tinoco J, Salcedo-Jáquez M, Sánchez-Anguiano LF, Berumen-Segovia LO, Rábago-Sánchez E, Liesenfeld O (2015) Toxoplasma gondii infection in interstate truck drivers: a case-control seroprevalence study. Parasit Vectors 8:77. https://doi.org/10.1186/s13071-015-0690-z CrossRefPubMedPubMedCentral

Title: Presence of Toxoplasma gondii infection in brain as a potential cause of risky behavior: a report of 102 autopsy cases
Authors: Dorota Samojłowicz
Joanna Twarowska-Małczyńska
Aleksandra Borowska-Solonynko
Łukasz A. Poniatowski
Nipika Sharma
Mieszko Olczak
Publication date: 01-02-2019
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Clinical Microbiology & Infectious Diseases / Issue 2/2019
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-018-3427-z

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