Skip to main content
Top
Published in: AIDS and Behavior 4/2018

01-04-2018 | Brief Report

Prescription Opioid Use is Associated with Virologic Failure in People Living with HIV

Authors: John Flores, Yuanyuan Liang, Norma S. Ketchum, Barbara J. Turner, Delia Bullock, Roberto Villarreal, Jennifer S. Potter, Barbara S. Taylor

Published in: AIDS and Behavior | Issue 4/2018

Login to get access

Abstract

Prescription opioid misuse is a rising epidemic in the U.S., and people living with HIV are at increased risk. We assessed the association between prescription opioid use and virologic failure in HIV+ patients in the South Texas HIV Cohort. We found prescription opioid use was significantly associated with virologic failure, after adjustment for age, race, gender, insurance status, years living with HIV, reported HIV risk factor, chronic hepatitis C virus infection, current substance abuse, and care engagement. These findings suggest that opioid analgesic use may have negative consequences beyond misuse in people living with HIV.
Literature
1.
go back to reference Jeevanjee S, Penko J, Guzman D, Miaskowski C, Bangsberg DR, Kushel MB. Opioid analgesic misuse is associated with incomplete antiretroviral adherence in a cohort of HIV-infected indigent adults in san francisco. AIDS Behav. 2014;18(7):1352–8.CrossRefPubMedPubMedCentral Jeevanjee S, Penko J, Guzman D, Miaskowski C, Bangsberg DR, Kushel MB. Opioid analgesic misuse is associated with incomplete antiretroviral adherence in a cohort of HIV-infected indigent adults in san francisco. AIDS Behav. 2014;18(7):1352–8.CrossRefPubMedPubMedCentral
2.
go back to reference Turner AN, Maierhofer C, Funderburg NT, Sydney B, et al. High levels of self-reported prescription opioid use by HIV-positive individuals. AIDS care. 2016;28(12):1559–65.CrossRefPubMedPubMedCentral Turner AN, Maierhofer C, Funderburg NT, Sydney B, et al. High levels of self-reported prescription opioid use by HIV-positive individuals. AIDS care. 2016;28(12):1559–65.CrossRefPubMedPubMedCentral
4.
go back to reference Edelman EJ, Gordon K, Becker WC, et al. Receipt of opioid analgesics by HIV-infected and uninfected patients. J Gen Intern Med. 2013;28(1):82–90.CrossRefPubMed Edelman EJ, Gordon K, Becker WC, et al. Receipt of opioid analgesics by HIV-infected and uninfected patients. J Gen Intern Med. 2013;28(1):82–90.CrossRefPubMed
5.
go back to reference Masur H, Brooks JT, Benson CA, et al. Prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: updated guidelines from the centers for disease control and prevention, national institutes of health, and HIV medicine association of the infectious diseases society of america. Clin Infect Dis. 2014;58(9):1308–11.CrossRefPubMedPubMedCentral Masur H, Brooks JT, Benson CA, et al. Prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: updated guidelines from the centers for disease control and prevention, national institutes of health, and HIV medicine association of the infectious diseases society of america. Clin Infect Dis. 2014;58(9):1308–11.CrossRefPubMedPubMedCentral
6.
go back to reference Liang Y, Turner BJ. Assessing risk for drug overdose in a national cohort: role for both daily and total opioid dose? J Pain. 2015;16(4):318–25.CrossRefPubMed Liang Y, Turner BJ. Assessing risk for drug overdose in a national cohort: role for both daily and total opioid dose? J Pain. 2015;16(4):318–25.CrossRefPubMed
7.
go back to reference Robinson-Papp J, Elliot K, Simpson D, Morgello S. Problematic prescription opioid use in an HIV-infected cohort: the importance of universal toxicology testing. J Acquir Immune Defic Syndr. 2012;61(2):187–93.CrossRefPubMedPubMedCentral Robinson-Papp J, Elliot K, Simpson D, Morgello S. Problematic prescription opioid use in an HIV-infected cohort: the importance of universal toxicology testing. J Acquir Immune Defic Syndr. 2012;61(2):187–93.CrossRefPubMedPubMedCentral
8.
go back to reference Vijayaraghavan M, Penko J, Guzman D, Miaskowski C, Kushel M. Primary care providers’ judgments of opioid analgesic misuse in a community-based cohort of HIV-infected indigent adults. J Gen Intern Med. 2011;26(4):412–8.CrossRefPubMed Vijayaraghavan M, Penko J, Guzman D, Miaskowski C, Kushel M. Primary care providers’ judgments of opioid analgesic misuse in a community-based cohort of HIV-infected indigent adults. J Gen Intern Med. 2011;26(4):412–8.CrossRefPubMed
9.
go back to reference Tsao JC, Stein JA, Dobalian A. Pain, problem drug use history, and aberrant analgesic use behaviors in persons living with HIV. Pain. 2007;133(1–3):128–37.CrossRefPubMedPubMedCentral Tsao JC, Stein JA, Dobalian A. Pain, problem drug use history, and aberrant analgesic use behaviors in persons living with HIV. Pain. 2007;133(1–3):128–37.CrossRefPubMedPubMedCentral
10.
go back to reference Lum P, Little S, Botski M, et al. Opioid-prescribing practices and provider confidence recognizing opioid analgesic abuse in HIV primary care settings. J Acquir Immune Defic Syndr. 2011;56(1):91–7.CrossRef Lum P, Little S, Botski M, et al. Opioid-prescribing practices and provider confidence recognizing opioid analgesic abuse in HIV primary care settings. J Acquir Immune Defic Syndr. 2011;56(1):91–7.CrossRef
12.
go back to reference Meng J, Sindberg GM, Roy S. Disruption of gut homeostasis by opioids accelerates HIV disease progression. Front Microbiol. 2015;6(643):1–11. Meng J, Sindberg GM, Roy S. Disruption of gut homeostasis by opioids accelerates HIV disease progression. Front Microbiol. 2015;6(643):1–11.
Metadata
Title
Prescription Opioid Use is Associated with Virologic Failure in People Living with HIV
Authors
John Flores
Yuanyuan Liang
Norma S. Ketchum
Barbara J. Turner
Delia Bullock
Roberto Villarreal
Jennifer S. Potter
Barbara S. Taylor
Publication date
01-04-2018
Publisher
Springer US
Published in
AIDS and Behavior / Issue 4/2018
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-017-1842-2

Other articles of this Issue 4/2018

AIDS and Behavior 4/2018 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.