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European Radiology
Published in: European Radiology 2/2018

01-02-2018 | Breast

Preoperative prediction of sentinel lymph node metastasis in breast cancer based on radiomics of T2-weighted fat-suppression and diffusion-weighted MRI

Authors: Yuhao Dong, Qianjin Feng, Wei Yang, Zixiao Lu, Chunyan Deng, Lu Zhang, Zhouyang Lian, Jing Liu, Xiaoning Luo, Shufang Pei, Xiaokai Mo, Wenhui Huang, Changhong Liang, Bin Zhang, Shuixing Zhang

Published in: European Radiology | Issue 2/2018

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Abstract

Objectives

To predict sentinel lymph node (SLN) metastasis in breast cancer patients using radiomics based on T2-weighted fat suppression (T2-FS) and diffusion-weighted MRI (DWI).

Methods

We enrolled 146 patients with histologically proven breast cancer. All underwent pretreatment T2-FS and DWI MRI scan. In all, 10,962 texture and four non-texture features were extracted for each patient. The 0.623 + bootstrap method and the area under the curve (AUC) were used to select the features. We constructed ten logistic regression models (orders of 1–10) based on different combination of image features using stepwise forward method.

Results

For T2-FS, model 10 with ten features yielded the highest AUC of 0.847 in the training set and 0.770 in the validation set. For DWI, model 8 with eight features reached the highest AUC of 0.847 in the training set and 0.787 in the validation set. For joint T2-FS and DWI, model 10 with ten features yielded an AUC of 0.863 in the training set and 0.805 in the validation set.

Conclusions

Full utilisation of breast cancer-specific textural features extracted from anatomical and functional MRI images improves the performance of radiomics in predicting SLN metastasis, providing a non-invasive approach in clinical practice.

Key Points

• SLN biopsy to access breast cancer metastasis has multiple complications.
• Radiomics uses features extracted from medical images to characterise intratumour heterogeneity.
• We combined T 2 -FS and DWI textural features to predict SLN metastasis non-invasively.
Appendix
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Metadata
Title
Preoperative prediction of sentinel lymph node metastasis in breast cancer based on radiomics of T2-weighted fat-suppression and diffusion-weighted MRI
Authors
Yuhao Dong
Qianjin Feng
Wei Yang
Zixiao Lu
Chunyan Deng
Lu Zhang
Zhouyang Lian
Jing Liu
Xiaoning Luo
Shufang Pei
Xiaokai Mo
Wenhui Huang
Changhong Liang
Bin Zhang
Shuixing Zhang
Publication date
01-02-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 2/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-5005-7

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