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BMC Pregnancy and Childbirth

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Open Access 01-12-2020 | Premature Birth | Research article

Impact of history of myomectomy on preterm birth risk in women with a leiomyomatous uterus: a propensity score analysis

Authors: Emmanuel Rault, Pierre Delorme, François Goffinet, Aude Girault

Published in: BMC Pregnancy and Childbirth | Issue 1/2020

Abstract

Background

To evaluate if women with a history of myomectomy have a modified preterm birth risk compared to women with myomas during pregnancy.

Methods

Retrospective cohort study including all women with a history of myomectomy (operated group) or uterine myomas during pregnancy (unoperated group) who delivered in a tertiary center between January, 2011 and December, 2017. The operated group included women who had a myomectomy history with or without myomas during the ongoing pregnancy. The unoperated group included women with uterine myoma(s) seen on at least one ultrasound during pregnancy without history of myomectomy. The primary outcome was preterm birth < 37 weeks, and the secondary outcome spontaneous preterm birth < 37 weeks. To control for confounding factors, a propensity score approach was used. Two sensitivity analysis were performed, one repeating the analysis using the propensity score after excluding operated women with persistent myomas and one using a classical multivariable logistic regression model.

Results

The cohort included 576 women: 283 operated women and 293 unoperated women. The rate of preterm birth was similar in the two groups: 12.6% in the unoperated group and 12.0% in the operated group (p = 0.82). No difference in preterm birth risk was shown between unoperated and operated women in the cohort matched on the propensity score: OR 0.86; 95%CI [0.47–1.59]. These results were consistent for spontaneous preterm birth (OR 1.61; 95%CI [0.61–4.23]) and for the sensitivity analyses.

Conclusion

In women with a leiomyomatous uterus, a history of myomectomy is not associated with a reduced preterm birth risk.

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Title: Impact of history of myomectomy on preterm birth risk in women with a leiomyomatous uterus: a propensity score analysis
Authors: Emmanuel Rault
Pierre Delorme
François Goffinet
Aude Girault
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Premature Birth
Uterine Myoma
Published in: BMC Pregnancy and Childbirth / Issue 1/2020
Electronic ISSN: 1471-2393
DOI: https://doi.org/10.1186/s12884-020-03413-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact of history of myomectomy on preterm birth risk in women with a leiomyomatous uterus: a propensity score analysis

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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