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01-12-2019 | Premature Birth | Maternal-Fetal Medicine

Periodontopathogenic microbiota, infectious mechanisms and preterm birth: analysis with structural equations (cohort—BRISA)

Authors: Elisa Miranda Costa, Camilla Silva de Araujo Figueiredo, Rafiza Félix Marão Martins, Cecília Claudia Costa Ribeiro, Claudia Maria Coelho Alves, Maria Lúcia Talarico Sesso, Ruchele Dias Nogueira, Maria da Conceição Saraiva, Marco Antônio Barbieri, Heloisa Bettiol, Antônio Augusto Moura da Silva, Erika Bárbara Abreu Fonseca Thomaz

Published in: Archives of Gynecology and Obstetrics | Issue 6/2019

Abstract

Purpose

The association between periodontopathogenic microbiota and preterm birth (PTB) has been overly studied. However, the biological mechanisms involved are little known. The objective is to evaluate the effect of periodontopathogenic bacteria burden (PBB), periodontal disease and other infections during pregnancy on preterm birth (PTB), through Structural Equation Modeling.

Methods

This was a case–control study nested in a prospective cohort called BRISA, including 330 pregnant women, 110 cases and 220 controls. This study included the following variables: cytokines interleukin-10 (IL-10) and transforming growth factor beta (TGF-β), periodontal disease, PBB, age, socioeconomic status (SES), systemic infections and PTB. The correlations between variables were analyzed using Standardized Coefficient (SC).

Results

Greater PBB interfered positively with the occurrence of periodontal disease (SC: 0.027; p: 0.011), but these were not associated with the cytokines studied, nor with PTB. The lower serum levels of IL-10 (SC − 0.330; p 0.022) and TGF-β (SC − 0.612; p < 0.001), and the presence of other systemic infections during pregnancy (SC 0.159; 0.049) explained the higher occurrence of PTB.

Conclusion

It is possible that only the more severe periodontal disease and other systemic infections are capable of altering the cascade of cytokines regulating the inflammatory process and have an effect on the occurrence of PTB.

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Title: Periodontopathogenic microbiota, infectious mechanisms and preterm birth: analysis with structural equations (cohort—BRISA)
Authors: Elisa Miranda Costa
Camilla Silva de Araujo Figueiredo
Rafiza Félix Marão Martins
Cecília Claudia Costa Ribeiro
Claudia Maria Coelho Alves
Maria Lúcia Talarico Sesso
Ruchele Dias Nogueira
Maria da Conceição Saraiva
Marco Antônio Barbieri
Heloisa Bettiol
Antônio Augusto Moura da Silva
Erika Bárbara Abreu Fonseca Thomaz
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Keywords: Premature Birth
Gingival Diseases
Respiratory Microbiota
Cytokines
Published in: Archives of Gynecology and Obstetrics / Issue 6/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05355-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Periodontopathogenic microbiota, infectious mechanisms and preterm birth: analysis with structural equations (cohort—BRISA)

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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