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Open Access 01-12-2010 | Research

Preimplant factors affecting postimplant CT-determined prostate volume and the CT/TRUS volume ratio after transperineal interstitial prostate brachytherapy with ¹²⁵I free seeds

Authors: Akitomo Sugawara, Jun Nakashima, Etsuo Kunieda, Hirohiko Nagata, Hirotaka Asakura, Mototsugu Oya, Naoyuki Shigematsu

Published in: Radiation Oncology | Issue 1/2010

Abstract

Background

The aim was to identify preimplant factors affecting postimplant prostate volume and the increase in prostate volume after transperineal interstitial prostate brachytherapy with ¹²⁵I free seeds.

Methods

We reviewed the records of 180 patients who underwent prostate brachytherapy with ¹²⁵I free seeds for clinical T1/T2 prostate cancer. Eighty-one (45%) of the 180 patients underwent neoadjuvant hormonal therapy. No patient received supplemental external beam radiotherapy. Postimplant computed tomography was undertaken, and postimplant dosimetric analysis was performed. Univariate and multivariate analyses were performed to identify preimplant factors affecting postimplant prostate volume by computed tomography and the increase in prostate volume after implantation.

Results

Preimplant prostate volume by transrectal ultrasound, serum prostate-specific antigen, number of needles, and number of seeds implanted were significantly correlated with postimplant prostate volume by computed tomography. The increase in prostate volume after implantation was significantly higher in patients with neoadjuvant hormonal therapy than in those without. Preimplant prostate volume by transrectal ultrasound, number of needles, and number of seeds implanted were significantly correlated with the increase in prostate volume after implantation. Stepwise multiple linear regression analysis showed that preimplant prostate volume by transrectal ultrasound and neoadjuvant hormonal therapy were significant independent factors affecting both postimplant prostate volume by computed tomography and the increase in prostate volume after implantation.

Conclusions

The results of the present study show that preimplant prostate volume by transrectal ultrasound and neoadjuvant hormonal therapy are significant preimplant factors affecting both postimplant prostate volume by computed tomography and the increase in prostate volume after implantation.

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Hoinkis C, Hakenberg OW, Lehmann D, Winkler C, Wirth MP, Herrmann T: Evaluation of dose-volume histograms after prostate seed implantation. 4-year experience. Strahlenther Onkol 2004, 180: 550-556. 10.1007/s00066-004-1337-8CrossRefPubMed

Martin T, Baltas D, Kurek R, Roddiger S, Kontova M, Anagnostopoulos G, Dannenberg T, Buhleier T, Skazikis G, Tunn U, Zamboglou N: 3-D conformal HDR brachytherapy as monotherapy for localized prostate cancer. A pilot study. Strahlenther Onkol 2004, 180: 225-232. 10.1007/s00066-004-1215-4CrossRefPubMed

Pinkawa M, Maurer U, Mulhern A, Gagel B, Block T, Borchers H, Grieger J, Henkel T, Eble M: Inverse automated treatment planning with and without individual optimization in interstitial permanent prostate brachytherapy with high- and low-activity 125I. Strahlenther Onkol 2003, 179: 417-422.PubMed

Nag S, Bice W, DeWyngaert K, Prestidge B, Stock R, Yu Y: The American Brachytherapy Society recommendations for permanent prostate brachytherapy postimplant dosimetric analysis. Int J Radiat Oncol Biol Phys 2000, 46: 221-230. 10.1016/S0360-3016(99)00351-XCrossRefPubMed

Dogan N, Mohideen N, Glasgow GP, Keys K, Flanigan RC: Effect of prostatic edema on CT-based postimplant dosimetry. Int J Radiat Oncol Biol Phys 2002, 53: 483-489. 10.1016/S0360-3016(02)02762-1CrossRefPubMed

Taussky D, Austen L, Toi A, Yeung I, Williams T, Pearson S, McLean M, Pond G, Crook J: Sequential evaluation of prostate edema after permanent seed prostate brachytherapy using CT-MRI fusion. Int J Radiat Oncol Biol Phys 2005, 62: 974-980. 10.1016/j.ijrobp.2004.12.012CrossRefPubMed

Taussky D, Yeung I, Williams T, Pearson S, McLean M, Pond G, Crook J: Rectal-wall dose dependence on postplan timing after permanent-seed prostate brachytherapy. Int J Radiat Oncol Biol Phys 2006, 65: 358-363. 10.1016/j.ijrobp.2005.12.024CrossRefPubMed

Al-Qaisieh B, Ash D, Bottomley DM, Carey BM: Impact of prostate volume evaluation by different observers on CT-based post-implant dosimetry. Radiother Oncol 2002, 62: 267-273. 10.1016/S0167-8140(01)00475-3CrossRefPubMed

Lee WR, Roach M, Michalski J, Moran B, Beyer D: Interobserver variability leads to significant differences in quantifiers of prostate implant adequacy. Int J Radiat Oncol Biol Phys 2002, 54: 457-461. 10.1016/S0360-3016(02)02950-4CrossRefPubMed

10.

Yamada Y, Potters L, Zaider M, Cohen G, Venkatraman E, Zelefsky MJ: Impact of intraoperative edema during transperineal permanent prostate brachytherapy on computer-optimized and preimplant planning techniques. Am J Clin Oncol 2003, 26: e130-135. 10.1097/01.coc.0000091353.67232.e5CrossRefPubMed

11.

Saito S, Nagata H, Kosugi M, Toya K, Yorozu A: Brachytherapy with permanent seed implantation. Int J Clin Oncol 2007, 12: 395-407. 10.1007/s10147-007-0710-xCrossRefPubMed

12.

Nath R, Anderson LL, Luxton G, Weaver KA, Williamson JF, Meigooni AS: Dosimetry of interstitial brachytherapy sources: recommendations of the AAPM Radiation Therapy Committee Task Group No. 43. American Association of Physicists in Medicine. Med Phys 1995, 22: 209-234. 10.1118/1.597458CrossRefPubMed

13.

Ash D, Al-Qaisieh B, Bottomley D, Carey B, Joseph J: The impact of hormone therapy on post-implant dosimetry and outcome following Iodine-125 implant monotherapy for localised prostate cancer. Radiother Oncol 2005, 75: 303-306. 10.1016/j.radonc.2005.03.015CrossRefPubMed

14.

Crook J, McLean M, Catton C, Yeung I, Tsihlias J, Pintilie M: Factors influencing risk of acute urinary retention after TRUS-guided permanent prostate seed implantation. Int J Radiat Oncol Biol Phys 2002, 52: 453-460. 10.1016/S0360-3016(01)02658-XCrossRefPubMed

15.

Niehaus A, Merrick GS, Butler WM, Wallner KE, Allen ZA, Galbreath RW, Adamovich E: The influence of isotope and prostate volume on urinary morbidity after prostate brachytherapy. Int J Radiat Oncol Biol Phys 2006, 64: 136-143. 10.1016/j.ijrobp.2005.06.035CrossRefPubMed

16.

Terk MD, Stock RG, Stone NN: Identification of patients at increased risk for prolonged urinary retention following radioactive seed implantation of the prostate. J Urol 1998, 160: 1379-1382. 10.1016/S0022-5347(01)62542-4CrossRefPubMed

17.

Vargas C, Ghilezan M, Hollander M, Gustafson G, Korman H, Gonzalez J, Martinez A: A new model using number of needles and androgen deprivation to predict chronic urinary toxicity for high or low dose rate prostate brachytherapy. J Urol 2005, 174: 882-887. 10.1097/01.ju.0000169136.55891.21CrossRefPubMed

18.

Badiozamani KR, Wallner K, Sutlief S, Ellis W, Blasko J, Russell K: Anticipating prostatic volume changes due to prostate brachytherapy. Radiat Oncol Investig 1999, 7: 360-364. 10.1002/(SICI)1520-6823(1999)7:6<360::AID-ROI6>3.0.CO;2-DCrossRefPubMed

19.

Potters L, Cao Y, Calugaru E, Torre T, Fearn P, Wang XH: A comprehensive review of CT-based dosimetry parameters and biochemical control in patients treated with permanent prostate brachytherapy. Int J Radiat Oncol Biol Phys 2001, 50: 605-614. 10.1016/S0360-3016(01)01473-0CrossRefPubMed

20.

Tanaka O, Hayashi S, Matsuo M, Nakano M, Uno H, Ohtakara K, Miyoshi T, Deguchi T, Hoshi H: Effect of edema on postimplant dosimetry in prostate brachytherapy using CT/MRI fusion. Int J Radiat Oncol Biol Phys 2007, 69: 614-618. 10.1016/j.ijrobp.2007.05.082CrossRefPubMed

21.

Pinkawa M, Gagel B, Piroth MD, Borchers H, Jakse G, Eble MJ: Changes of dose delivery distribution within the first month after permanent interstitial brachytherapy for prostate cancer. Strahlenther Onkol 2006, 182: 525-530. 10.1007/s00066-006-1529-5CrossRefPubMed

22.

Crook J, McLean M, Yeung I, Williams T, Lockwood G: MRI-CT fusion to assess postbrachytherapy prostate volume and the effects of prolonged edema on dosimetry following transperineal interstitial permanent prostate brachytherapy. Brachytherapy 2004, 3: 55-60. 10.1016/j.brachy.2004.05.001CrossRefPubMed

23.

McNeely LK, Stone NN, Presser J, Chircus JH, Stock RG: Influence of prostate volume on dosimetry results in real-time 125I seed implantation. Int J Radiat Oncol Biol Phys 2004, 58: 292-299. 10.1016/S0360-3016(03)00783-1CrossRefPubMed

Title: Preimplant factors affecting postimplant CT-determined prostate volume and the CT/TRUS volume ratio after transperineal interstitial prostate brachytherapy with 125I free seeds
Authors: Akitomo Sugawara
Jun Nakashima
Etsuo Kunieda
Hirohiko Nagata
Hirotaka Asakura
Mototsugu Oya
Naoyuki Shigematsu
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2010
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-5-86

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Preimplant factors affecting postimplant CT-determined prostate volume and the CT/TRUS volume ratio after transperineal interstitial prostate brachytherapy with ¹²⁵I free seeds

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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