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Open Access 01-12-2021 | Pregnancy Cholestasis | Research article

Perinatal outcomes of neonates born from different endometrial preparation protocols after frozen embryo transfer: a retrospective cohort study

Authors: Cheng Li, Yi-Chen He, Jing-Jing Xu, Yu Wang, Han Liu, Chen-Chi Duan, Chao-Yi Shi, Lei Chen, Jie Wang, Jian-Zhong Sheng, He-Feng Huang, Yan-Ting Wu

Published in: BMC Pregnancy and Childbirth | Issue 1/2021

Abstract

Background

Previous studies have focused on pregnancy outcomes after frozen embryo transfer (FET) performed using different endometrial preparation protocols. Few studies have evaluated the effect of endometrial preparation on pregnancy-related complications. This study was designed to explore the association between different endometrial preparation protocols and adverse obstetric and perinatal complications after FET.

Methods

We retrospectively included all FET cycles (n = 12,950) in our hospital between 2010 and 2017, and categorized them into three groups, natural cycles (NC), hormone replacement therapy (HRT) and ovarian stimulation (OS) protocols. Pregnancy-related complications and subsequent neonatal outcomes were compared among groups.

Results

Among all 12,950 FET cycles, the live birth rate was slightly lower for HRT cycles than for NC (HRT vs. NC: 28.15% vs. 31.16%, p < 0.001). The pregnancy loss rate was significantly higher in OS or HRT cycles than in NC (HRT vs. NC: 17.14% vs. 10.89%, p < 0.001; OS vs. NC: 16.44% vs. 10.89%, p = 0.001). Among 3864 women with live birth, preparing the endometrium using OS or HRT protocols increased the risk of preeclampsia, and intrahepatic cholestasis of pregnancy (ICP) in both singleton and multiple deliveries. Additionally, OS and HRT protocols increased the risk of low birth weight (LBW) and small for gestational age (SGA) in both singletons and multiples after FET.

Conclusion

Compared with HRT or OS protocols, preparing the endometrium with NC was associated with the decreased risk of pregnancy-related complications, as well as the decreased risk of LBW and SGA after FET.

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Title: Perinatal outcomes of neonates born from different endometrial preparation protocols after frozen embryo transfer: a retrospective cohort study
Authors: Cheng Li
Yi-Chen He
Jing-Jing Xu
Yu Wang
Han Liu
Chen-Chi Duan
Chao-Yi Shi
Lei Chen
Jie Wang
Jian-Zhong Sheng
He-Feng Huang
Yan-Ting Wu
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Pregnancy Cholestasis
Pre-Eclampsia
Published in: BMC Pregnancy and Childbirth / Issue 1/2021
Electronic ISSN: 1471-2393
DOI: https://doi.org/10.1186/s12884-021-03791-9

2024 ASCO Annual Meeting

Springer Medicine

Perinatal outcomes of neonates born from different endometrial preparation protocols after frozen embryo transfer: a retrospective cohort study

Abstract

Background

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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