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Journal of Gastrointestinal Surgery

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01-11-2018 | Original Article

Predictive Value of Preoperative Sarcopenia in Patients with Gastric Cancer: a Meta-analysis and Systematic Review

Authors: Zhengdao Yang, Xin Zhou, Bin Ma, Yanan Xing, Xue Jiang, Zhenning Wang

Published in: Journal of Gastrointestinal Surgery | Issue 11/2018

Abstract

Purpose

The impact of preoperative sarcopenia on postoperative complications and overall survival has been recently debated. Our meta-analysis aims to ascertain whether preoperative sarcopenia increases the risk of poor outcomes and to attempt to provide new ideas for the prognosis of outcomes for patients with gastric cancer.

Methods

We searched for all relevant articles on PubMed, the EMBASE database, and Web of Science (up to September 1, 2017). Data synthesis and statistical analysis were carried out using RevMan 5.3 software.

Results

Thirteen studies involving 4262 patients who underwent gastrectomy for gastric cancer were analyzed (sarcopenia group = 1234; non-sarcopenia group = 3028). The results showed that preoperative sarcopenia significantly associated with poor pathological staging (high pT: OR = 1.86, 95% CI = 1.49–2.31; P < 0.01; pN+: OR = 1.61, 95% CI = 1.33–1.94; P < 0.01; high TNM category: OR = 1.84, 95% CI = 1.53–2.22; P < 0.01). Patients with preoperative sarcopenia had an increased risk of total postoperative complications (OR = 2.17, 95% CI = 1.53–3.08; P < 0.01), severe complications (OR = 1.65, 95% CI = 1.09–2.50; P = 0.02), and poorer OS (HR = 1.70, 95% CI = 1.45–1.99; P < 0.01). The results of subgroup analyses revealed that patients with preoperative sarcopenia over 65 years old and those from Asian populations had higher risks for total postoperative complications and severe complications.

Conclusion

This meta-analysis reveals that preoperative sarcopenia may be used as a new indicator of poor pathological staging, impaired overall survival, and increased postoperative complications. Notably, patients with gastric cancer who are over 65 years old and from Asia should be routinely screened for sarcopenia before surgery to adequately assess the risk of postoperative complications in clinical practice.

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Title: Predictive Value of Preoperative Sarcopenia in Patients with Gastric Cancer: a Meta-analysis and Systematic Review
Authors: Zhengdao Yang
Xin Zhou
Bin Ma
Yanan Xing
Xue Jiang
Zhenning Wang
Publication date: 01-11-2018
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 11/2018
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-018-3856-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Predictive Value of Preoperative Sarcopenia in Patients with Gastric Cancer: a Meta-analysis and Systematic Review

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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